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Estrogens and Gastric Secretion

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      Summary

      The gastric secretory response in patients and monkeys was studied before, during, and after treatment with estrogens. No significant decrease in acid or pepsin secretion could be demonstrated, although a suggestion of a decrease in acid secretion was noted. This does not, by itself, explain the alleged benefits of estrogens on the course of peptic disease and neither does it explain some of the well recognized sex differences in peptic disease and acid secretion.

      References

        • Clark D.H.
        Peptic ulcer in women.
        Brit. Med. J. 1953; 1: 1254-1257
        • MacKay C.
        Perforated peptic ulcer in the west of Scotland: a survey of 5,343 cases during 1954-1963.
        Brit. Med. J. 1966; 1: 701-705
        • Doll R.
        • Jones F.A.
        Occupational factors in the etiology of gastric and duodenal ulcers.
        Med. Res. Counc. Spec. Rep. (London). 1951; 276: 1-96
        • Winkelstein A.
        A possible relationship between the ductless glands secreting the sex hormones and peptic ulcer.
        J. Mount Sinai Hosp. N.Y. 1940; 7: 29-31
        • Sandweiss D.J.
        • Saltzstein H.C.
        • Farbman A.A.
        The relation of sex hormones to peptic ulcer.
        Amer. J. Dig. Dis. 1939; 6: 6-12
        • Crean G.P.
        The endocrine system and the stomach.
        Vitamins Hormones (N.Y.). 1963; : 215-280
        • McDonald I.
        Gastric activity during the menstrual cycle.
        Gastroenterology SO. 1956; : 602-607
        • Clark D.H.
        • Tankel H.I.
        Gastric acid and plasma histaminase during pregnancy.
        Lancet. 1954; 2: 886-890
        • Spiro H.M.
        • Schwartz R.D.
        • Pilot M.L.
        Peptic ulcer in pregnancy: a serial study of gastric secretion during pregnancy.
        Amer. J. Dig. Dis. (New Series). 1959; : 289-296
        • Truelove S.C.
        Stilbesterol, phenobarbitone and diet in chronic duodenal ulcer.
        Brit. Med. J. 1960; 2: 559-566
        • Doll R.
        • Hill I.D.
        • Hutton C.F.
        Treatment of gastric ulcer with carbenoxolone sodium and estrogens.
        Gut. 1965; 6: 19-24
        • Kay A.W.
        Effect of large doses of histamine on gastric secretion of HCl.
        Brit. Med. J. 1953; 2: 77-80
        • Anson M.L.
        The estimation of pepsin, trypsin, papain and cathepsin with hemoglobin.
        J. Gen. Physiol. 1938; 22: 79-89
        • Vakel B.J.
        • Mulekar A.M.
        Studies with the maximal histamine test.
        Gut. 1965; 7: 364-371
        • Baron J.H.
        Peptic ulcer, gastric secretion and body build.
        Gut. 1963; 5: 83-85
        • Ojha K.N.
        • Wood D.R.
        The inhibitory effects of stilbesterol on gastric secretion in cats.
        Brit. J. Pharmacol. 1950; 5: 389-394
        • McCarthy J.D.
        • Evans S.O.
        • Dragstedt L.R.
        Gastric secretion in dogs during pregnancy and lactation.
        Gastroenterology. 1954; 27: 275-280
        • Clark D.H.
        Gastric secretion in dogs during pregnancy and lactation.
        Scot. Med. J. 1957; 2: 392-395
        • Hartiala K.J.
        • Kassinen A.
        • Sautarinen H.
        The beneficial effects of estrogens on experimental cinchophen ulcer.
        Ann. Med. Exp. Fenn. 1954; 82: 444-448
        • Mylire E.
        Regeneration of fundi mucosa in rats: effects of estrone and castration.
        Arch. Path. (Chicago). 1956; 2: 6
        • Ghosh M.N.
        Inhibition of acid gastric secretion in the rat by chorionic gonadotropin.
        J. Physiol. (London). 1959; 147: 585-590
        • Kahlson G.
        • Lilja B.
        • Svensson S.E.
        Physiological protection against gastric ulceration during pregnancy and lactation in the rat.
        Lancet. 1964; 2: 1269-1272
        • Fell B.F.
        • Smith K.A.
        • Campbell R.M.
        Hypertrophic and hyperplastic changes in the alimentary canal of the lactating rat.
        J. Path. Bact. 1963; 85: 179-188
        • Shelesnyak M.C.
        Histamine releasing activity of natural estrogens.
        Proc. Soc. Exp. Biol. Med. 1959; 100: 739-741
        • Parbhoo S.P.
        • Johnston I.D.A.
        Effects of oestrogens and progestogens on gastric secretion in patients with duodenal ulcer.
        Gut. 1966; 7: 612-618
        • Connell A.M.
        • Fletcher J.
        • Howel Jones J.
        • Langman M.J.S.
        • Leonard Jones J.E.
        • Pygott F.
        Oestrogens and high protein and high-carbohydrate diets in the treatment of duodenal ulcer (abstr.).
        Gut. 1966; 7: 717