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Decreased Complexity of Serum N-glycan Structures Associates with Successful Fecal Microbiota Transplantation for Recurrent Clostridioides difficile Infection

      N-glycosylation is a common and yet complex posttranslational process that covalently links glycans (complex oligosaccharides) to proteins and lipids, affecting cellular structure and function. Glycans have important biological functions in protein maturation and turnover, cell adhesion and trafficking, and receptor binding and activation.
      • Lauc G.
      • et al.
      In the immune system, glycosylation also modulates the function of immunoglobulin G (IgG). Differential N-glycosylation of its fragment crystallisable (Fc) affects IgG effector functions through modified binding affinity to the Fc-receptors (FcyRs), enabling its ability to act as a pro- or anti-inflammatory agent.
      • Lauc G.
      • et al.
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