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Using Salmonella enterica Serotype Typhimurium to Model Intestinal Fibrosis

  • Beth A. McCormick
    Correspondence
    Address requests for reprints to: Beth A. McCormick, PhD, Department of Pediatric Gastroenterology and Nutrition, Massachusetts General Hospital and Harvard Medical School, 114 16th Street (114-3503), Charlestown, Massachusetts 02129. fax: (617) 726-4172.
    Affiliations
    Department of Pediatric Gastroenterology and Nutrition, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts
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Published:February 13, 2008DOI:https://doi.org/10.1053/j.gastro.2008.01.019
      See “Chronic enteric Salmonella infection in mice leads to severe and persistent intestinal fibrosis” by Grassl GA, Valdez Y, Bergstrom KSB, et al on page 768.
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      Linked Article

      • Chronic Enteric Salmonella Infection in Mice Leads to Severe and Persistent Intestinal Fibrosis
        GastroenterologyVol. 134Issue 3
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          Background & Aims: Intestinal fibrosis and stricture formation are serious complications of Crohn’s disease, often requiring surgical intervention. Unfortunately, the mechanisms underlying intestinal fibrosis development are poorly understood, in part because of the lack of relevant animal models. Here, we present a novel murine model of severe and persistent intestinal fibrosis caused by chronic bacterial-induced colitis. Methods: Mice were treated with streptomycin 24 hours prior to oral infection with Salmonella enterica serovar Typhimurium.
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