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Pathophysiology and treatment of functional dyspepsia

  • Jan Tack
    Correspondence
    Address requests for reprints to: Jan Tack, M.D., Ph.D., Division of Gastroenterology, Department of Internal Medicine, University Hospital Gasthuisberg, Herestraat 49, B-3000 Leuven, Belgium. fax: (32) 16-34-44-19
    Affiliations
    Division of Gastroenterology, Department of Internal Medicine, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium
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  • Raf Bisschops
    Affiliations
    Division of Gastroenterology, Department of Internal Medicine, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium
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  • Giovanni Sarnelli
    Affiliations
    Division of Gastroenterology, Department of Internal Medicine, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium
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      Dyspeptic symptoms, defined as discomfort or pain in the upper part of the abdomen, occur very commonly in the general population. Epidemiologic surveys suggest that 15%–20% of the general population in Western countries experience dyspepsia over the course of 1 year.
      • Talley N.J.
      • Zinsmeister A.R.
      • Schleck C.D.
      • Melton III, L.J.
      Dyspepsia and dyspepsia subgroups a population-based study.
      • Agreus L.
      • Svardsudd K.
      • Nyren O.
      • Tibblin G.
      Irritable bowel syndrome and dyspepsia in the general population overlap and lack of stability over time.
      Despite the fact that only about 1 in 4 people with dyspeptic symptoms choose to consult a physician,
      • Talley N.J.
      • Zinsmeister A.R.
      • Schleck C.D.
      • Melton III, L.J.
      Dyspepsia and dyspepsia subgroups a population-based study.
      dyspepsia is a clinical problem of considerable magnitude for the health care system due to the high prevalence and the chronic or recurrent nature of symptoms.
      • Penston J.G.
      • Pounder R.E.
      A survey of dyspepsia in Great Britain.

      Abbreviations used in this paper:

      5-HT (5-hydroxytryptamine), PPI (proton pump inhibitor), SSRI (selective serotonin reuptake inhibitor)
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