A year in the life of the gastric mucosa


      GASTROENTEROLOGY 2000;119:252-254
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      Linked Article

      • Atrophy and intestinal metaplasia one year after cure of H. pylori infection: A prospective, randomized study
        GastroenterologyVol. 119Issue 1
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          Background & Aims: Helicobacter pylori–infected gastric mucosa evolves through stages of chronic gastritis, intestinal metaplasia (IM), glandular atrophy (GA), and dysplasia before carcinoma develops. We studied if H. pylori eradication would alter the course of premalignant histologic changes in the stomach. Methods: Volunteers from the Yantai County in China underwent upper endoscopy with biopsy specimens obtained from the antrum and corpus. H. pylori–infected subjects were randomized to receive either a 1-week course of omeprazole, amoxicillin, and clarithromycin (OAC) or placebo.
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