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A High-Fat Diet Is Associated With Endotoxemia That Originates From the Gut

Published:February 10, 2012DOI:https://doi.org/10.1053/j.gastro.2012.01.034
      Endotoxemia, characterized by an excess of circulating bacterial wall lipopolysaccharide, is associated with systemic inflammation and the metabolic syndrome. Placing 8 healthy subjects on a Western-style diet for 1 month induced a 71% increase in plasma levels of endotoxin activity (endotoxemia), whereas a prudent-style diet reduced levels by 31%. The Western-style diet might, therefore, contribute to endotoxemia by causing changes in gastrointestinal barrier function or the composition of the microbiota. Endotoxemia might also develop in individuals with gastrointestinal barrier impairment. Therapeutic reagents that reduce endotoxemia might reduce systemic inflammation in patients with gastrointestinal diseases or metabolic syndrome.

      Keywords

      Abbreviations used in this paper:

      LPS (lipopolysaccharide)
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      Linked Article

      • High Fructose Consumption Can Induce Endotoxemia
        GastroenterologyVol. 143Issue 3
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          We read the article speculating that a high-fat diet is associated with endotoxemia originating from the gut which is recently published in Gastroenterology by Pendyala et al.1 They also proposed that the Western-style diet could contribute to endotoxemia by causing changes in gastrointestinal barrier function or the composition of enteric flora. We offer the following comments.
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