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Sustained slowing effect of lentils on gastric emptying of solids in humans and dogs

  • H.C. Lin
    Correspondence
    Address requests for reprints to: Henry C. Lin, M.D., CedarsSinai Medical Center, Suite 7511, 8700 Beverly Boulevard, Los Angeles, California 90048-1869.
    Footnotes
    Affiliations
    Departments of Medicine and Surgery, Cedars-Sinai Medical Center, Los Angeles, California USA

    Veterans Administration Medical Center, Sepulveda, California, USA

    School of Medicine, UCLA, Los Angeles, California USA
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  • N.A. Moller
    Affiliations
    Departments of Medicine and Surgery, Cedars-Sinai Medical Center, Los Angeles, California USA

    Veterans Administration Medical Center, Sepulveda, California, USA

    School of Medicine, UCLA, Los Angeles, California USA
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  • M.M. Wolinsky
    Affiliations
    Departments of Medicine and Surgery, Cedars-Sinai Medical Center, Los Angeles, California USA

    Veterans Administration Medical Center, Sepulveda, California, USA

    School of Medicine, UCLA, Los Angeles, California USA
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  • B.H. Kim
    Affiliations
    Departments of Medicine and Surgery, Cedars-Sinai Medical Center, Los Angeles, California USA

    Veterans Administration Medical Center, Sepulveda, California, USA

    School of Medicine, UCLA, Los Angeles, California USA
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  • J.E. Doty
    Affiliations
    Departments of Medicine and Surgery, Cedars-Sinai Medical Center, Los Angeles, California USA

    Veterans Administration Medical Center, Sepulveda, California, USA

    School of Medicine, UCLA, Los Angeles, California USA
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  • J.H. Meyer
    Affiliations
    Departments of Medicine and Surgery, Cedars-Sinai Medical Center, Los Angeles, California USA

    Veterans Administration Medical Center, Sepulveda, California, USA

    School of Medicine, UCLA, Los Angeles, California USA
    Search for articles by this author
  • Author Footnotes
    ∗ Dr. Lin was a Veterans Affairs Associate Investigator when these studies were performed.
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      Abstract

      The distal small intestine is an especially potent site for carbohydrate-triggered intestinal inhibition of gastric emptying of solids. Poorly digestible carbohydrates, such as lentils, may escape proximal absorption, travel over time to reach these inhibitory mechanisms, and slow the gastric emptying of a later meal. A slowing effect on gastric emptying may be associated with a lowering effect on postprandial glucose. The aims of this study were to determine (a) whether lentils (a poorly digestible carbohydrate) vs. bread (an easily digestible carbohydrate) eaten as a premeal (with equal amounts of carbohydrates) slow the gastric emptying of a second solid meal taken 4.0–4.5 hours later and (b) whether a slowing effect on the gastric emptying of the second meal is associated with a lower postprandial glucose response. We found that in 7 dogs and 10 humans, gastric emptying of the second meal was delayed after a lentil premeal compared with a bread premeal. However, there was no difference in the glucose response to the second meal under the two conditions.
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      References

        • Jain NK
        • Boivin M
        • Zinsmeister AR
        • Brown ML
        • Malagelada JR
        • DiMagno EP
        Effect of ileal perfusion of carbohydrates and amylase inhibitor on gastrointestinal hormones and emptying.
        Gastroenterology. 1989; 96: 377-387
        • Lin HC
        • Kim BH
        • Elashoff JD
        • Doty JE
        • Gu Y-G
        • Meyer JH
        Gastric emptying of solid food is most potently inhibited by carbohydrate in the canine distal ileum.
        Gastroenterology. 1992; 102: 430-438
        • Anderson IH
        • Levine AS
        • Levitt MD
        Incomplete absorption of the carbohydrate in all-purpose wheat flour.
        N Engl J Med. 1981; 304: 891-892
        • Stephen AM
        • Haddad AC
        • Phillips SF
        Passage of carbohydrate into the colon.
        Gastroenterology. 1983; 85: 589-595
        • Jenkins DJA
        • Wolever TMS
        • Taylor RH
        • Griffiths C
        • Krzeminska K
        • Lawrie JA
        • Bennett CM
        • Goff DV
        • Sarson DL
        • Bloom SR
        Slow release dietary carbohydrate improves second meal tolerance.
        Am J Clin Nutr. 1982; 35: 1339-1346
        • Wright RA
        • Thompson D
        • Syed I
        Simultaneous markers for fluid and solid gastric emptying. New variations on an old theme: Concise communication.
        J Nucl Med. 1981; 22: 772-776
        • Meyer JH
        • Dressman J
        • Fink AS
        • Amidon G
        Effect of size and density on canine gastric emptying of non-digestible solids.
        Gastroenterology. 1989; 89: 805-813
        • Lin HC
        • Doty JE
        • Reedy TJ
        • Meyer JH
        Inhibition of gastric emptying by glucose depends on the length of the intestine exposed to the nutrient.
        Am J Physiol. 1989; 256: G204-G411
        • Collins PJ
        • Horowite M
        • Cook DJ
        • Harding PE
        • Shearman DJC
        Gastric emptying in normal subjects—A reproducible technique using a single scintillation camera and computer system.
        Gut. 1983; 24: 1117-1125
        • Mourot J
        • Thouvenot P
        • Couet C
        • Antoine JM
        • Krobicka A
        • Debry G
        Relationship between the rate of gastric emptying and glucose and insulin responses to starchy foods in young healthy adults.
        Am J Clin Nutr. 1988; 48: 1035-1040
        • Torsdottir I
        • Alpsten M
        • Andersson D
        • Brummer RJM
        • Andersson H
        Effect of different starchy foods in composite meals on gastric emptying rate and glucose metabolism.
        Hum Nutr Clin Nutr. 1984; 38C: 329-338
        • Hutson WR
        • Roehrkasse RL
        • Wald A
        Influence of gender and menopause on gastric emptying and motility.
        Gastroenterology. 1989; 96: 11-17
        • Jenkins DJA
        • Ghafari H
        • Wolever TMS
        • Taylor RH
        • Jenkins AL
        • Barker HM
        • Fielden H
        • Bowling AC
        Relationship between rate of digestion of foods and post-prandial glycaemia.
        Diabetologia. 1982; 22: 450-455
        • Englyst HN
        • Trowell H
        • Southgate DAT
        • Cummings JH
        Dietary fiber and resistant starch.
        Am J Clin Nutr. 1987; 46: 873-874
        • Holm J
        • Lundquist I
        • Bjorck I
        • Eliasson AC
        • George N
        Degree of starch gelatinization, digestion rate of starch in vitro, and metabolic response in rats.
        Am J Clin Nutr. 1988; 47: 1010-1016
        • Jaffe WIG
        • Lette CLV
        Heat-labile growth inhibitory factors in beans (Phaseolus Vulgaris).
        J Nutr. 1986; 94: 203-210
        • Jenkins DJA
        • Thorne MJ
        • Wolever TMS
        • Jenkins AL
        • Rao AV
        • Thompson LU
        The effect of starch-protein interaction in wheat on the glycemic response and rate of in vitro digestion.
        Am J Clin Nutr. 1987; 45: 946-951
        • Jenkins DJA
        • Thorne MJ
        • Camelon K
        • Jenkins A
        • Rao AV
        • Taylor RH
        • Thompson LU
        • Kalmusky J
        • Reichert R
        • Francis T
        Effect of processing on digestibility and the blood glucose response: a study of lentils.
        Am J Clin Nutr. 1982; 36: 1093-1101
        • Layer P
        • Carlson GL
        • DiMagno EP
        Partially purified white bean Amylase inhibitor reduces starch digestion in vitro and inactivates intraduodenal amylase in humans.
        Gastroenterology. 1985; 88: 1895-1902
        • Wolever TMS
        • Jenkins DJA
        • Kalmusky J
        • Giordano C
        • Giudio S
        • Jenkins AL
        • Thompson LU
        • Wong GS
        • Josse RG
        Glycemic response to pasta: effect of surface area, degree of cooking, and protein enrichment.
        Diabetes Care. 1986; 9: 401-403
        • Yoon JH
        • Thompson LU
        • Jenkins DJA
        The effect of phytic acid on in vitro rate of starch digestibility and blood-glucose response.
        Am J Clin Nutr. 1983; 38: 835-842
        • Wong S
        • O'Dea K
        Importance of physical form rather than viscosity in determining the rate of starch hydrolysis in legumes.
        Am J Clin Nutr. 1983; 37: 66-70
        • James AH
        The nature of the gastric contents in man.
        in: James AH The physiology of gastric digestion. Edward Arnold, London1957: 1-24
        • Meyer JH
        • Kelly KA
        Canine pancreatic responses to intestinally perfused proteins and protein digest.
        Am J Physiol. 1976; 231: G682-G691