| |
Article Title |
Author(s) |
Type |
Pages |
|
|
Cover 1
|
|
Miscellaneous
|
page OFC
|
| This Month in Gastroenterology |
| |
Article Title |
Author(s) |
Type |
Pages |
|
|
This Month in Gastroenterology
30 July 2009
Esophageal adenocarcinoma, associated with reflux disease and Barrett's esophagus, is the malignancy with the fastest growing incidence. Traditionally, esophagectomy was the treatment of choice for cu...
|
Jan Tack,
John M. Carethers
|
Discussion
|
pages 747-750
|
| Gastroenterology and Hepatology News |
| |
Article Title |
Author(s) |
Type |
Pages |
|
|
Federal Agencies Join Private Industry to Protect Against Agroterrorism
21 July 2009
The US Department of Agriculture, Department of Health and Human Services' Food and Drug Administration (FDA), Department of Homeland Security, and the Federal Bureau of Investigation announced on Jun...
|
Les Lang
|
Full-length article
|
page 751
|
|
|
Computed Tomography Colonography Compared With Colonoscopy for Patients at Increased Risk of Colorectal Cancer
21 July 2009
Computed tomographic (CT) colonography may offer patients at increased risk of colorectal cancer (CRC) an alternative to colonoscopy that is less invasive, is better tolerated, and has adequate diagno...
|
Les Lang
|
Full-length article
|
pages 751-752
|
|
|
Gastrin Plays a Significant Role in Helicobacter-Induced Stomach Cancer
21 July 2009
A study of the role of Helicobacter infection in the development of microbially induced gastric cancer has found that gastrin plays a key role in the development as well as the location of this diseas...
|
Les Lang
|
Full-length article
|
page 752
|
|
|
The Institute of Medicine Releases Initial Comparative Effectiveness Research Priorities
21 July 2009
A new report from the Institute of Medicine (IOM) released in June 2009 recommends 100 initial health topics for priority attention and funding from a new national comparative effectiveness research e...
|
Les Lang
|
Full-length article
|
pages 752-753
|
| Mini-Reviews and Perspectives |
| |
Article Title |
Author(s) |
Type |
Pages |
|
|
Telomere Dysfunction and DNA Damage Checkpoints in Diseases and Cancer of the Gastrointestinal Tract
21 July 2009
Aging occurs after the reproductive phase of life has been completed. The aging process is associated with a progressive decline in organ maintenance and an increasing risk of diseases, particularly c...
|
K. Lenhard Rudolph,
Daniel Hartmann,
Oliver G. Opitz
|
Full-length article
|
pages 754-762
|
| Comment From the Editors |
| |
Article Title |
Author(s) |
Type |
Pages |
|
|
Surveillance in Barrett's Esophagus: Lessons from Behavioral Economics
29 July 2009
Several observations in clinical practice seem to be difficult to explain on a rational basis. These include doing “too much,” such as repeated testing, parallel testing, expensive and extensive testi...
|
Hashem B. El-Serag,
Aanand D. Naik
|
Editorial
|
pages 763-765
|
|
|
Developing Irritable Bowel Syndrome Guidelines Through Meta-analyses: Does the Emperor Really Have New Clothes?
29 July 2009
Clinical guidelines are often based on systematic reviews and meta-analyses. There have been many such meta-analyses regarding the treatment of irritable bowel syndrome (IBS), even though individual h...
|
Michael Camilleri,
Emeran A. Mayer
|
Editorial
|
pages 766-769
|
| In Memoriam |
| |
Article Title |
Author(s) |
Type |
Pages |
|
|
David Schauer, DVM, PhD
27 July 2009
It is with a deep sense of loss and profound sadness that we regrettably acknowledge the sudden death of our friend and colleague, Dr David Schauer, on June 7, 2009—one day after his 48th birthday. D...
|
James G. Fox
|
Editorial
|
pages 770-771
|
| Editorials |
| |
Article Title |
Author(s) |
Type |
Pages |
|
|
Nonalcoholic Fatty Liver Disease Liver Fat Score and Fat Equation to Predict and Quantitate Hepatic Steatosis: Promising But Not Prime Time!
27 July 2009
|
Naga Chalasani
|
Editorial
|
pages 772-775
|
|
|
Intestinal Lipid Absorption, GLP-2, and CD36: Still More Mysteries to Moving Fat
29 July 2009
|
Elizabeth P. Newberry,
Nicholas O. Davidson
|
Editorial
|
pages 775-778
|
|
|
Can Too Much Acid Sour Your Pancreas?
30 July 2009
|
John A. Williams,
Matthew J. DiMagno
|
Editorial
|
pages 779-782
|
|
|
Finding and Killing the CRABs of Pancreatic Cancer
29 July 2009
|
Meredith E. Caldwell,
David A. Tuveson
|
Editorial
|
pages 782-785
|
|
|
Deciphering Hepatocellular Carcinoma: From Bench to Bedside and Back
29 July 2009
|
Wolfram Goessling
|
Editorial
|
pages 786-788
|
| Clinical Challenges and Images in GI |
| |
Article Title |
Author(s) |
Type |
Pages |
|
|
Brunner's Gland Hamartoma
25 February 2009
Question: A 54-year-old man was referred from the local hospital because of the finding of 1 ampullary tumor via esophagogastroduodenoscopy. He presented a 1-week history of progressively worsening ep...
|
Jung-Chun Lin,
Tsai-Yuan Hsieh,
De-Chuan Chan
|
Discussion
|
page 789
|
|
|
Atypical Esophagitis
30 July 2009
Question: A 74-year-old man was admitted because of progressive dysphagia to solids of 6 months duration. His past medical history was unremarkable. The patient mentioned that he had been admitted for...
|
Helmut Neumann,
Dörthe Kuester,
Klaus Mönkemüller
|
Discussion
|
page 790
|
|
|
Young Female With Pancreatic Mass
31 July 2009
Question: A previously healthy, 22-year-old woman underwent computed tomography and magnetic resonance imaging of the abdomen to evaluate acute-onset, self-limited, lower abdominal pain. A 5.8-cm cyst...
|
Manmeet S. Padda,
Harry R. Aslanian,
C. Theoharis
|
Discussion
|
page 791
|
| Electronic Clinical Challenges and Images in GI |
| |
Article Title |
Author(s) |
Type |
Pages |
|
|
Unusual Colon Polyps
31 July 2009
Question: A 39-year-old Hispanic man with a 7-year history of intermittent left lower quadrant abdominal pain and hematochezia. He is otherwise healthy. On several computed tomography (CT) scans, ther...
|
Shou-jiang Tang,
Yisheng V. Fang
|
Discussion
|
pages e1-e2
|
|
|
A Woman With Increasing Dypsnea
03 August 2009
Question: A 78-year-old woman was referred to our Gastroenterology unit because of deteriorating chronic reflux symptoms and increasing dyspnea. She had a long clinical history of mild pyrosis and reg...
|
Eduardo Redondo-Cerezo,
Natividad Sánchez-Manjavacas,
Raquel Martínez Fernández
|
Discussion
|
pages e3-e4
|
|
|
An Uncommon Cause of Iron Deficiency Anemia
03 August 2009
Question: A 46-year-old Caucasian man with a past medical history significant for several large, tubulovillous adenomas by colonoscopy a year prior, active alcohol abuse, and a distant history of thro...
|
Emmanuelle D. Williams,
Alex Seamon,
Cynthia Levy
|
Discussion
|
pages e5-e6
|
|
|
Hepatogastric Fistula in One Patient With Liver Abscess
03 August 2009
Question: An 86-year-old man with no relevant medical history visited our hospital for chronic constipation for 2 years. Colonoscopy and computed tomography (CT) showed adenocarcinoma of ascending col...
|
Chia-Yang Hsu,
Jin-Hwang Liu,
Chien-Wei Su
|
Discussion
|
pages e7-e8
|
|
|
Struck Dysphagic
30 July 2009
Question: An 85-year-old woman presented with a 9-month history of cramping chest pain and dysphagia for liquids and solids. Initial weight loss from 65 to 51 kg stabilized on a self-imposed diet of n...
|
Mark R. Fox,
Christoph Gubler
|
Discussion
|
pages e9-e10
|
| Imaging and Advanced Technology |
| |
Article Title |
Author(s) |
Type |
Pages |
|
|
Computed Tomography Colonography: A Current Appraisal
21 July 2009
Computed tomography (CT) colonography (CTC) is a specialized CT examination of the abdomen and pelvis in which imaging data, combined with advanced imaging software, provides a comprehensive, full str...
|
C. Daniel Johnson
|
Full-length article
|
pages 792-794
|
| Reviews in Basic and Clinical Gastroenterology |
| |
Article Title |
Author(s) |
Type |
Pages |
|
|
Coinfection With HIV-1 and HCV—A One-Two Punch
22 June 2009
Hepatitis C virus (HCV) infection is a major cause of chronic liver disease, cirrhosis, and death; it is estimated that 180 million persons are infected with HCV worldwide. The consequences of HCV are...
|
Arthur Y. Kim,
Raymond T. Chung
|
Review article
|
pages 795-814
|
| Clinical-Alimentary Tract |
| |
Article Title |
Author(s) |
Type |
Pages |
|
|
Endoscopic and Surgical Treatment of Mucosal (T1a) Esophageal Adenocarcinoma in Barrett's Esophagus
15 June 2009
Background & Aims: Endoscopic therapy is emerging as an alternative to surgical therapy in patients with mucosal (T1a) esophageal adenocarcinoma (EAC) given the low likelihood of lymph node metast...
|
Ganapathy A. Prasad,
Tsung Teh Wu,
Dennis A. Wigle,
Navtej S. Buttar,
Louis–Michel Wongkeesong,
Kelly T. Dunagan,
Lori S. Lutzke,
Lynn S. Borkenhagen,
Kenneth K. Wang
et al.
|
Full-length article
|
pages 815-823
|
|
|
Meta-analysis Shows That Prevalence of Epstein–Barr Virus-Positive Gastric Cancer Differs Based on Sex and Anatomic Location
14 May 2009
Background & Aims: Epstein–Barr virus (EBV) has been causally associated with cancer; some gastric carcinomas have a monoclonal EBV genome in every cancer cell, indicating that they arose from a s...
|
Gwen Murphy,
Ruth Pfeiffer,
M. Constanza Camargo,
Charles S. Rabkin
|
Full-length article
 
|
pages 824-833
|
|
|
Analysis of HLA and Non-HLA Alleles Can Identify Individuals at High Risk for Celiac Disease
18 May 2009
Background & Aims: Celiac disease (CD) is a common chronic disorder of the small intestine, resulting from aberrant cellular responses to gluten peptides, and often remains undiagnosed. It is a co...
|
Jihane Romanos,
Cleo C. van Diemen,
Ilja M. Nolte,
Gosia Trynka,
Alexandra Zhernakova,
Jingyuan Fu,
Maria Teresa Bardella,
Donatella Barisani,
Ross McManus,
David A. van Heel,
Cisca Wijmenga
et al.
|
Full-length article
|
pages 834-840.e3
|
|
|
Reversal of a Virtual Lesion in Human Pharyngeal Motor Cortex by High Frequency Contralesional Brain Stimulation
08 May 2009
Background & Aims: Excitatory brain stimulation with repetitive transcranial magnetic stimulation (rTMS) has been proposed as a treatment for dysphagia after stroke. Moreover, 1-Hz rTMS can induce...
|
Samantha Jefferson,
Satish Mistry,
Emilia Michou,
Salil Singh,
John C. Rothwell,
Shaheen Hamdy
et al.
|
Full-length article
|
pages 841-849.e1
|
| Clinical Advances in Liver, Pancreas, and Biliary Tract |
| |
Article Title |
Author(s) |
Type |
Pages |
|
|
A System of Classifying Microvascular Invasion to Predict Outcome After Resection in Patients With Hepatocellular Carcinoma
15 June 2009
Background & Aims: Hepatocellular carcinoma (HCC) recurs in approximately 70% of cases after resection. Vascular invasion by tumor cells can be classified as gross or microscopic (microvascular in...
|
Sasan Roayaie,
Iris N. Blume,
Swan N. Thung,
Maria Guido,
Maria–Isabel Fiel,
Spiros Hiotis,
Daniel M. Labow,
Josep M. Llovet,
Myron E. Schwartz
et al.
|
Full-length article
|
pages 850-855
|
|
|
Intravenous N-Acetylcysteine Improves Transplant-Free Survival in Early Stage Non-Acetaminophen Acute Liver Failure
15 June 2009
Background & Aims: N-acetylcysteine (NAC), an antidote for acetaminophen poisoning, might benefit patients with non–acetaminophen-related acute liver failure. Methods: In a prospective, double-bli...
|
William M. Lee,
Linda S. Hynan,
Lorenzo Rossaro,
Robert J. Fontana,
R. Todd Stravitz,
Anne M. Larson,
Timothy J. Davern,
Natalie G. Murray,
Timothy McCashland,
Joan S. Reisch,
Patricia R. Robuck,
Acute Liver Failure Study Group
et al.
|
Full-length article
|
pages 856-864.e1
|
| Clinical-Liver, Pancreas, and Liver Tract |
| |
Article Title |
Author(s) |
Type |
Pages |
|
|
Prediction of Non-Alcoholic Fatty Liver Disease and Liver Fat Using Metabolic and Genetic Factors
15 June 2009
Background & Aims: Our aims were to develop a method to accurately predict non-alcoholic fatty liver disease (NAFLD) and liver fat content based on routinely available clinical and laboratory data...
|
Anna Kotronen,
Markku Peltonen,
Antti Hakkarainen,
Ksenia Sevastianova,
Robert Bergholm,
Lina M. Johansson,
Nina Lundbom,
Aila Rissanen,
Martin Ridderstråle,
Leif Groop,
Marju Orho–Melander,
Hannele Yki–Järvinen
et al.
|
Full-length article
|
pages 865-872
|
|
|
Decline in Male Sexual Desire, Function, and Satisfaction During and After Antiviral Therapy for Chronic Hepatitis C
15 June 2009
Background & Aims: The recommended therapy for chronic hepatitis C, pegylated interferon and ribavirin for 24 or 48 weeks, has many known adverse side effects. The aim of this study was to evaluat...
|
Lorna M. Dove,
Raymond C. Rosen,
Darmendra Ramcharran,
Abdus S. Wahed,
Steven H. Belle,
Robert S. Brown,
Jay H. Hoofnagle,
Virahep-C Study Group
et al.
|
Full-length article
|
pages 873-884.e1
|
|
|
Secondary Prophylaxis of Hepatic Encephalopathy: An Open-Label Randomized Controlled Trial of Lactulose Versus Placebo
08 June 2009
Background & Aims: Hepatic encephalopathy (HE) is associated with a poor prognosis. Lactulose is used for the treatment of HE. There is no study on the prevention of recurrence of HE using lactulo...
|
Barjesh Chander Sharma,
Praveen Sharma,
Amit Agrawal,
Shiv Kumar Sarin
|
Full-length article
|
pages 885-891.e1
|
|
|
Addition of Propranolol and Isosorbide Mononitrate to Endoscopic Variceal Ligation Does Not Reduce Variceal Rebleeding Incidence
28 May 2009
Background & Aims: Endoscopic variceal ligation (EVL) and propranolol are standard secondary prophylaxis therapies for variceal bleeding. Addition of isosorbide mononitrate (ISMN) to propranolol i...
|
Ashish Kumar,
Sanjeev Kumar Jha,
Praveen Sharma,
Saroj Dubey,
Pankaj Tyagi,
Barjesh Chander Sharma,
Shiv Kumar Sarin
et al.
|
Full-length article
|
pages 892-901.e1
|
| Basic-Alimentary Tract |
| |
Article Title |
Author(s) |
Type |
Pages |
|
|
Elevated Dnmt3a Activity Promotes Polyposis in ApcMin Mice by Relaxing Extracellular Restraints on Wnt Signaling
18 May 2009
Background & Aims: Aberrant DNA methylation is a common early event in neoplasia, but it is unclear how this relates to dysregulation of DNA (cytosine-5) methyltransferases (Dnmts). Here we use kn...
|
Michael S. Samuel,
Hiromu Suzuki,
Michael Buchert,
Tracy L. Putoczki,
Niall C. Tebbutt,
Therése Lundgren–May,
Aliki Christou,
Melissa Inglese,
Minoru Toyota,
Joan K. Heath,
Robyn L. Ward,
Paul M. Waring,
Matthias Ernst
et al.
|
Full-length article
|
pages 902-913.e11
|
|
|
Saccharomyces boulardii Inhibits EGF Receptor Signaling and Intestinal Tumor Growth in Apcmin Mice
01 June 2009
Background & Aims: Saccharomyces boulardii (Sb) is a probiotic yeast with anti-inflammatory and anti-microbial activities and has been used for decades in the prevention and treatment of a variety...
|
Xinhua Chen,
Johannes Fruehauf,
Jeffrey D. Goldsmith,
Hua Xu,
Kianoosh K. Katchar,
Hon–Wai Koon,
Dezheng Zhao,
Efi G. Kokkotou,
Charalabos Pothoulakis,
Ciarán P. Kelly
et al.
|
Full-length article
|
pages 914-923
|
|
|
Mucosal Addressin Cell-Adhesion Molecule-1 Controls Plasma-Cell Migration and Function in the Small Intestine of Mice
18 May 2009
Background & Aims: Immunoglobulin (Ig) A secretion into the intestinal lumen is an important immune mechanism of the gastrointestinal (GI) tract. B cells proliferate and differentiate into IgA-sec...
|
Angela Schippers,
Christoph Leuker,
Oliver Pabst,
Annika Kochut,
Blair Prochnow,
Achim D. Gruber,
Euphemia Leung,
Geoffrey W. Krissansen,
Norbert Wagner,
Werner Müller
et al.
|
Full-length article
|
pages 924-933
|
|
|
Human and Mouse Colon Cancer Utilizes CD95 Signaling for Local Growth and Metastatic Spread to Liver
15 June 2009
Background & Aims: Analysis of clinical colon cancer specimens show alterations in the CD95 (Fas Ag/Fas L) pathway as tumors progress from local to metastatic disease, suggesting that this pathway...
|
Hanchen Li,
Xueli Fan,
Calin Stoicov,
Jian Hua Liu,
Sharif Zubair,
Elena Tsai,
Ronald Ste. Marie,
Timothy C. Wang,
Stephen Lyle,
Evelyn Kurt–Jones,
JeanMarie Houghton
et al.
|
Full-length article
|
pages 934-944.e4
|
|
|
Induction of Protein Tyrosine Kinase 6 in Mouse Intestinal Crypt Epithelial Cells Promotes DNA Damage–Induced Apoptosis
08 June 2009
Background & Aims: Protein tyrosine kinase 6 (PTK6) is expressed in epithelial linings of the gastrointestinal tract. PTK6 sensitizes the nontransformed Rat1a fibroblast cell line to apoptotic sti...
|
Andrea Haegebarth,
Ansu O. Perekatt,
Wenjun Bie,
Jessica J. Gierut,
Angela L. Tyner
et al.
|
Full-length article
|
pages 945-954
|
|
|
Ca2+-Dependent K+ Efflux Regulates Deoxycholate-Induced Apoptosis of BHK-21 and Caco-2 Cells
31 March 2009
Background & Aims: Deoxycholate (DC) has proapoptotic and tumorigenic effects in different cell types of the gastrointestinal tract. Exposure of BHK-21 (stromal) cells to DC induces Ca2+ entry at ...
|
Andrea Gerbino,
Marianna Ranieri,
Stefania Lupo,
Rosa Caroppo,
Lucantonio Debellis,
Isabella Maiellaro,
Mariano F. Caratozzolo,
Francesco Lopez,
Matilde Colella
et al.
|
Full-length article
|
pages 955-964.e2
|
|
|
Changes in Mucosal Homeostasis Predispose NHE3 Knockout Mice to Increased Susceptibility to DSS-Induced Epithelial Injury
18 May 2009
Background & Aims: NHE3 is a target of inhibition by proinflammatory cytokines and pathogenic bacteria, an event contributing to diarrhea in infectious and idiopathic colitis. In mice, NHE3 defici...
|
Pawel R. Kiela,
Daniel Laubitz,
Claire B. Larmonier,
Monica T. Midura–Kiela,
Maciej A. Lipko,
Nona Janikashvili,
Aiping Bai,
Robert Thurston,
Fayez K. Ghishan
et al.
|
Full-length article
|
pages 965-975.e10
|
|
|
Activation of Intestinal Cl− Secretion by Lubiprostone Requires the Cystic Fibrosis Transmembrane Conductance Regulator
18 May 2009
Background & Aims: Lubiprostone alleviates constipation by stimulating intestinal fluid secretion, purportedly through activation of ClC-2–type Cl− channels. Intestinal obstruction is also a recur...
|
Marcel J.C. Bijvelds,
Alice G.M. Bot,
Johanna C. Escher,
Hugo R. de Jonge
|
Full-length article
|
pages 976-985
|
|
|
ErbB Signaling Is Required for the Proliferative Actions of GLP-2 in the Murine Gut
11 June 2009
Background & Aims: Glucagon-like peptide-2 (GLP-2) is a 33-amino acid peptide hormone secreted by enteroendocrine cells in response to nutrient ingestion. GLP-2 stimulates crypt cell proliferation...
|
Bernardo Yusta,
Dianne Holland,
Jacqueline A. Koehler,
Marlena Maziarz,
Jennifer L. Estall,
Rachel Higgins,
Daniel J. Drucker
et al.
|
Full-length article
|
pages 986-996
|
|
|
Glucagon-Like Peptide-2 Increases Intestinal Lipid Absorption and Chylomicron Production via CD36
01 June 2009
Background & Aims: Excessive postprandial lipemia is a prevalent condition that results from intestinal oversecretion of apolipoprotein B48 (apoB48)-containing lipoproteins. Glucagon-like peptide-...
|
Joanne Hsieh,
Christine Longuet,
Adriano Maida,
Jasmine Bahrami,
Elaine Xu,
Christopher L. Baker,
Patricia L. Brubaker,
Daniel J. Drucker,
Khosrow Adeli
et al.
|
Full-length article
|
pages 997-1005.e4
|
|
|
Expression of the Chemokine Binding Protein M3 Promotes Marked Changes in the Accumulation of Specific Leukocytes Subsets Within the Intestine
08 June 2009
Background & Aims: Chemokines are small proteins that direct leukocyte trafficking under homeostatic and inflammatory conditions. We analyzed the differential expression of chemokines in distinct ...
|
Limin Shang,
Nanthakumar Thirunarayanan,
Abel Viejo–Borbolla,
Andrea P. Martin,
Milena Bogunovic,
Federica Marchesi,
Jay C. Unkeless,
Yin Ho,
Glaucia C. Furtado,
Antonio Alcami,
Miriam Merad,
Lloyd Mayer,
Sergio A. Lira
et al.
|
Full-length article
|
pages 1006-1018.e3
|
|
|
Sequential Role of Plasmacytoid Dendritic Cells and Regulatory T Cells in Oral Tolerance
03 April 2009
Background & Aims: Orally induced tolerance to environmental allergens prevents deleterious, systemic, delayed-type hypersensitivity responses via immune suppression mechanisms believed to include...
|
Bertrand Dubois,
Grégoire Joubert,
Mercedes Gomez de Agüero,
Marie Gouanvic,
Anne Goubier,
Dominique Kaiserlian
et al.
|
Full-length article
|
pages 1019-1028
|
|
|
Vagus Nerve Activity Augments Intestinal Macrophage Phagocytosis via Nicotinic Acetylcholine Receptor α4β2
08 May 2009
Background & Aims: The vagus nerve negatively regulates macrophage cytokine production via the release of acetylcholine (ACh) and activation of nicotinic acetylcholine receptors (nAChR). In variou...
|
Esmerij P. van der Zanden,
Susanne A. Snoek,
Sigrid E. Heinsbroek,
Oana I. Stanisor,
Caroline Verseijden,
Guy E. Boeckxstaens,
Maikel P. Peppelenbosch,
David R. Greaves,
Siamon Gordon,
Wouter J. De Jonge
et al.
|
Full-length article
|
pages 1029-1039.e4
|
|
|
Estrogen Rapidly Modulates 5-Hydroxytrytophan-Induced Visceral Hypersensitivity via GPR30 in Rats
02 April 2009
Background & Aims: Sex hormones have been reported to modulate visceral hypersensitivity (VH). Estrogen regulates neurons not only by binding to estrogen receptors (ERα and ERβ) to initiate transc...
|
Ching–Liang Lu,
Jen–Chuen Hsieh,
Nae J. Dun,
Tudor I. Oprea,
Paulus S. Wang,
Jiing–Chyuan Luo,
Han–Chieh Lin,
Full–Young Chang,
Shou–Dong Lee
et al.
|
Full-length article
|
pages 1040-1050
|
|
|
Nuclear Myosin II Regulates the Assembly of Preinitiation Complex for ICAM-1 Gene Transcription
31 March 2009
Background & Aims: Actin-myosin II motor converts chemical energy into force/motion in muscle and nonmuscle cells. The phosphorylation of 20-kilodalton regulatory myosin light chain (MLC20) is cri...
|
Qingjie Li,
Sushil K. Sarna
|
Full-length article
|
pages 1051-1060.e3
|
|
|
Modification of Gastric Mucin Oligosaccharide Expression in Rhesus Macaques After Infection With Helicobacter pylori
17 April 2009
Background & Aims: Helicobacter pylori attaches to mucin oligosaccharides that are expressed on host gastric epithelium. We used the rhesus macaque model to characterize the effect of H pylori inf...
|
Cara L. Cooke,
Hyun Joo An,
Jaehan Kim,
Don R. Canfield,
Javier Torres,
Carlito B. Lebrilla,
Jay V. Solnick
et al.
|
Full-length article
|
pages 1061-1071.e8
|
| Basic-Liver, Pancreas, and Biliary Tract |
| |
Article Title |
Author(s) |
Type |
Pages |
|
|
Ras Activity Levels Control the Development of Pancreatic Diseases
08 June 2009
Background & Aims: Differentiated pancreatic acinar cells expressing endogenous levels of mutant K-Ras do not spontaneously develop pancreatic ductal adenocarcinoma (PDAC). However, we hypothesize...
|
Baoan Ji,
Lilian Tsou,
Huamin Wang,
Sebastian Gaiser,
David Z. Chang,
Jaroslaw Daniluk,
Yan Bi,
Tobias Grote,
Daniel S. Longnecker,
Craig D. Logsdon
et al.
|
Full-length article
|
pages 1072-1082.e6
|
|
|
Reducing Extracellular pH Sensitizes the Acinar Cell to Secretagogue-Induced Pancreatitis Responses in Rats
18 May 2009
Background & Aims: Protease activation within the pancreatic acinar cell is a key early event in acute pancreatitis and may require low pH intracellular compartments. Clinical studies suggest that...
|
Madhavi Bhoomagoud,
Thomas Jung,
Jorunn Atladottir,
Thomas R. Kolodecik,
Christine Shugrue,
Anamika Chaudhuri,
Edwin C. Thrower,
Fred S. Gorelick
et al.
|
Full-length article
|
pages 1083-1092
|
|
|
Molecular Mechanisms of Pancreatic Dysfunction Induced by Protein Malnutrition
08 May 2009
Background & Aims: Dietary protein deficiency results in diminished capacity of the pancreas to secrete enzymes needed for macronutrient digestion. Previous work has suggested that modulation of t...
|
Stephen J. Crozier,
Louis G. D'Alecy,
Stephen A. Ernst,
Lauren E. Ginsburg,
John A. Williams
et al.
|
Full-length article
|
pages 1093-1101.e3
|
|
|
Combined Targeted Treatment to Eliminate Tumorigenic Cancer Stem Cells in Human Pancreatic Cancer
08 June 2009
Background & Aims: Pancreatic cancers contain exclusively tumorigenic cancer stem cells (CSCs), which are highly resistant to chemotherapy, resulting in a relative increase in CSC numbers during g...
|
Maria–Theresa Mueller,
Patrick C. Hermann,
Juliane Witthauer,
Belen Rubio–Viqueira,
Simon F. Leicht,
Stephan Huber,
Joachim W. Ellwart,
Mona Mustafa,
Peter Bartenstein,
Jan G. D'Haese,
Michael H. Schoenberg,
Frank Berger,
Karl–Walter Jauch,
Manuel Hidalgo,
Christopher Heeschen
et al.
|
Full-length article
|
pages 1102-1113
|
|
|
Enrichment and Clonal Culture of Progenitor Cells During Mouse Postnatal Liver Development in Mice
15 June 2009
Background & Aims: Stem and progenitor cells exist in normal postnatal livers. However, it has not been possible to clonally isolate or analyze postnatal liver stem/progenitor-like cells (PLSCs) d...
|
Akihide Kamiya,
Sei Kakinuma,
Yuji Yamazaki,
Hiromitsu Nakauchi
|
Full-length article
|
pages 1114-1126.e14
|
|
|
In Vitro Recapitulating of TP53 Mutagenesis in Hepatocellular Carcinoma Associated With Dietary Aflatoxin B1 Exposure
15 June 2009
Background & Aims: Dietary exposure to aflatoxin B1 (AFB1), in addition to other known factors, increases risk for human hepatocellular carcinoma (HCC). HCCs from AFB1-exposed individuals frequent...
|
Ahmad Besaratinia,
Sang-in Kim,
Pierre Hainaut,
Gerd P. Pfeifer
|
Full-length article
|
pages 1127-1137.e5
|
|
|
ANXA8 Down-regulation by EGF-FOXO4 Signaling Is Involved in Cell Scattering and Tumor Metastasis of Cholangiocarcinoma
20 April 2009
Background & Aims: The sarcomatoid change in cholangiocarcinoma (CC) contributes to more aggressive intrahepatic spread and widespread metastasis. Therefore, the aim of this study was to identify ...
|
Mi–Jin Lee,
Gyung–Ran Yu,
Hee–Jung Yoo,
Jong–Hyun Kim,
Byung–Il Yoon,
Yang–Kyu Choi,
Dae–Ghon Kim
et al.
|
Full-length article
|
pages 1138-1150.e9
|
|
|
Natural Killer Cell Functional Dichotomy in Chronic Hepatitis B and Chronic Hepatitis C Virus Infections
25 May 2009
Background & Aims: The phenotypic and functional characteristics of natural killer (NK) cells in chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infections are incompletely defined and...
|
Barbara Oliviero,
Stefania Varchetta,
Enrica Paudice,
Giuseppe Michelone,
Marco Zaramella,
Domenico Mavilio,
Francesca De Filippi,
Savino Bruno,
Mario U. Mondelli
et al.
|
Full-length article
|
pages 1151-1160.e7
|
