| This Month in Gastroenterology |
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This Month in Gastroenterology
14 July 2008
Current medical therapy for ulcerative colitis aims at suppression of inflammatory or immune responses through the use of aminosalicylates, steroids, immune suppressants, or infliximab. In severe case...
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Jan Tack,
John M. Carethers
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Discussion
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pages 331-334
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| Gastroenterology and Hepatology News |
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For Patients With Colon Cancer, a Family History of Colorectal Cancer is Associated With Reduced Risk of Recurrence and Death
10 July 2008
Among patients with advanced colon cancer receiving treatment that includes chemotherapy, a family history of colorectal cancer is associated with a significant reduction in cancer recurrence and deat...
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Les Lang
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Full-length article
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page 335
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Researchers Update Risk-of-Death Charts
10 July 2008
Researchers have now updated charts that show an American's risk of dying from a given cause over the next 10 years, based on age, gender, and smoking status. The charts appeared online June 10 in the...
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Les Lang
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Full-length article
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pages 335-336
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Three Sequencing Companies Join the 1000 Genomes Project
10 July 2008
Leaders of the 1000 Genomes Project announced on June 11 that 3 firms that have pioneered development of new sequencing technologies have joined the international effort to build the most detailed map...
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Les Lang
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Full-length article
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pages 336-337
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| Biographical Sketch |
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Ogilvie of the Ogilvie Syndrome
11 July 2008
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William S. Haubrich
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Personal report
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page 337
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| Perspective |
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The Detection of Flat and Depressed Colorectal Lesions: Which Endoscopic Imaging Approach?
14 July 2008
The secondary prevention of colorectal cancer (CRC) assumes that early detection and resection of precursor lesions disrupts the adenoma–carcinoma sequence and halts progression to invasive neoplastic...
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David P. Hurlstone
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Full-length article
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pages 338-343
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| Comment From the Editors |
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The Gastroenterology Fellowship Match—The First Two Years
11 July 2008
After a nearly 10-year period in which the market for gastrointestinal (GI) fellows was decentralized and chaotic, a fellowship Match was organized and conducted in June 2006. After the second year of...
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Muriel Niederle,
Deborah D. Proctor,
Alvin E. Roth
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Editorial
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pages 344-346
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| Editorials |
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Author(s) |
Type |
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Hedgehog Spikes Pancreas Regeneration
11 July 2008
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David A. Cano,
Matthias Hebrok
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Editorial
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pages 347-351
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Guardians of the Gut: Newly Appreciated Role of Epithelial Toll-Like Receptors in Protecting the Intestine
11 July 2008
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Matam Vijay-Kumar,
Andrew T. Gewirtz
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Editorial
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pages 351-354
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Biomarkers and Photodynamic Therapy for Barrett's Esophagus: Time to FISH or Cut Bait?
11 July 2008
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Stuart Jon Spechler,
Rhonda F. Souza
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Editorial
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pages 354-357
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Direct Versus Indirect Action of Cholecystokinin on Human Pancreatic Acinar Cells: Is It Time for a Judgment after a Century of Trial?
10 July 2008
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Ashok Saluja,
Craig Logsdon,
Pramod Garg
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Editorial
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pages 357-360
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| Clinical Challenges and Images in GI |
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Clinical Challenges and Images in GI
11 July 2008
Question: A 48-year-old man was referred for endoscopy because of epigastralgia for 6 months. He had no significant medical history. He denied nausea, vomiting, fever, weight loss, or passage of melen...
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Fat-Moon Suk,
Yun-Ho Lin,
Mao-Chih Hsieh
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Discussion
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page 361
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Clinical Challenges and Images in GI
11 July 2008
Question: A 70-year-old man was admitted to our department with lumbar pain, abdominal distention, and constipation for the last 3 days. On clinical examination, the abdomen was diffusely distended, a...
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Georgia Dedemadi,
George Georgoulis
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Discussion
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page 362
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Clinical Challenges and Images in GI
10 July 2008
Question: An otherwise healthy 58-year-old man was referred to the outpatient clinic by his general practitioner for intermittent bloody stools, abdominal pain, and chronic diarrhea over the past 6 mo...
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Jairo Gooskens,
Minneke J. Coenraad,
J.H. Marc Groeneveld,
Frans A. Prins,
Vincent T.H.B.M. Smit
et al.
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Discussion
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page 363
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| Electronic Clinical Challenges and Images in GI |
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Author(s) |
Type |
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Electronic Clinical Challenges and Images in GI
11 July 2008
Question: A 63-year-old man was referred for open access evaluation of iron deficiency anemia possibly owing to gastrointestinal (GI) blood loss. The patient's only complaint was generalized fatigue. ...
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Joo Ahn Lee,
Michael S. Taxier,
Charles J. Nicely
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Discussion
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pages e1-e3
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Electronic Clinical Challenges and Images in GI
10 July 2008
Question: A 48-year-old patient with colorectal cancer and peritoneal carcinomatosis underwent right hemicolectomy and resection of parts of the tumor that infiltrated the small bowel. Postoperative p...
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Volker Kaechele,
Thomas Seufferlein,
Sandra Pauls
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Discussion
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pages e4-e5
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Electronic Clinical Challenges and Images in GI
10 July 2008
Question: An 82-year-old man with a history of coronary heart disease and atrial fibrillation taking coumarin presented with hematochezia. He complained about vertigo and weight loss of 10 kg in 12 mo...
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Monther Bajbouj,
Veith Phillip,
Ruppert Langer,
Roland M. Schmid,
Leopold Ludwig
et al.
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Discussion
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pages e6-e7
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| Imaging and Advanced Technology |
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Defining Disease With Laser Precision: Laser Capture Microdissection in Gastroenterology
11 July 2008
Laser capture microdissection (LCM) is an efficient and precise method for obtaining pure cell populations or specific cells of interest from a given tissue sample. LCM has been applied to animal and ...
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Richard Blatt,
Shanthi Srinivasan
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Full-length article
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pages 364-369
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Utility of Biomarkers in Prediction of Response to Ablative Therapy in Barrett's Esophagus
08 May 2008
Background & Aims: Photodynamic therapy (PDT) has been shown to be effective in the treatment of high-grade dysplasia (HGD)/mucosal carcinoma in Barrett's esophagus (BE). Substantial proportions o...
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Ganapathy A. Prasad,
Kenneth K. Wang,
Kevin C. Halling,
Navtej S. Buttar,
Louis–Michel Wongkeesong,
Alan R. Zinsmeister,
Shannon M. Brankley,
Emily G. Barr Fritcher,
Wytske M. Westra,
Kausilia K. Krishnadath,
Lori S. Lutzke,
Lynn S. Borkenhagen
et al.
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Full-length article
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pages 370-379
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| Reviews in Basic and Clinical Gastroenterology |
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Type |
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Screening, Surveillance, and Primary Prevention for Colorectal Cancer: A Review of the Recent Literature
25 June 2008
Colorectal cancer (CRC) remains a major clinical and public health challenge, with 148,810 new cases and 49,960 deaths expected in the United States in 2008. The field of CRC research is dynamic and e...
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Charles J. Kahi,
Douglas K. Rex,
Thomas F. Imperiale
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Review article
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pages 380-399
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| Clinical - Alimentary Tract |
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A Randomized, Double-Blind, Sham-Controlled Study of Granulocyte/Monocyte Apheresis for Active Ulcerative Colitis
28 April 2008
Background & Aims: Activated granulocytes and monocytes/macrophages are implicated in the pathogenesis of ulcerative colitis. Open-label studies and clinical experience in Japan and Europe have su...
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Bruce E. Sands,
William J. Sandborn,
Brian Feagan,
Robert Löfberg,
Toshifumi Hibi,
Tao Wang,
Lisa–Marie Gustofson,
Cindy J. Wong,
Margaret K. Vandervoort,
Stephen Hanauer,
Adacolumn Study Group
et al.
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Full-length article
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pages 400-409
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Ulcerative Colitis Is a Disease of Accelerated Colon Aging: Evidence From Telomere Attrition and DNA Damage
17 April 2008
Background & Aims: Telomere shortening is implicated in cancer and aging and might link these 2 biologic events. We explored this hypothesis in ulcerative colitis (UC), a chronic inflammatory dise...
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Rosa Ana Risques,
Lisa A. Lai,
Teresa A. Brentnall,
Lin Li,
Ziding Feng,
Jasmine Gallaher,
Margaret T. Mandelson,
John D. Potter,
Mary P. Bronner,
Peter S. Rabinovitch
et al.
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Full-length article
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pages 410-418
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The Clinical Phenotype of Lynch Syndrome Due to Germ-Line PMS2 Mutations
06 May 2008
Background & Aims: Although the clinical phenotype of Lynch syndrome (also known as hereditary nonpolyposis colorectal cancer) has been well described, little is known about disease in PMS2 mutati...
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Leigha Senter,
Mark Clendenning,
Kaisa Sotamaa,
Heather Hampel,
Jane Green,
John D. Potter,
Annika Lindblom,
Kristina Lagerstedt,
Stephen N. Thibodeau,
Noralane M. Lindor,
Joanne Young,
Ingrid Winship,
James G. Dowty,
Darren M. White,
John L. Hopper,
Laura Baglietto,
Mark A. Jenkins,
Albert de la Chapelle
et al.
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Full-length article
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pages 419-428.e1
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Identification of EpCAM as the Gene for Congenital Tufting Enteropathy
16 May 2008
Background & Aims: Congenital tufting enteropathy (CTE) is a rare autosomal recessive diarrheal disorder presenting in the neonatal period. CTE is characterized by intestinal epithelial cell dyspl...
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Mamata Sivagnanam,
James L. Mueller,
Hane Lee,
Zugen Chen,
Stanley F. Nelson,
Dan Turner,
Stanley H. Zlotkin,
Paul B. Pencharz,
Bo–Yee Ngan,
Ondrej Libiger,
Nicholas J. Schork,
Joel E. Lavine,
Sharon Taylor,
Robert O. Newbury,
Richard D. Kolodner,
Hal M. Hoffman
et al.
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Full-length article
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pages 429-437
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| Clinical Advances in Liver, Pancreas, and Biliary Tract |
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Article Title |
Author(s) |
Type |
Pages |
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Critical Review of Clinical Trials of Bone Marrow Stem Cells in Liver Disease
20 May 2008
Morbidity and mortality from cirrhosis is increasing rapidly in the Western world. Currently the only effective treatment is liver transplantation, an increasingly limited and expensive resource. Cons...
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Diarmaid Dominic Houlihan,
Philip Noel Newsome
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Full-length article
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pages 438-450
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| Clinical - Liver, Pancreas, and Biliary Tract |
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Article Title |
Author(s) |
Type |
Pages |
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Peginterferon Alfa-2a and Ribavirin for 24 Weeks in Hepatitis C Type 1 and 4 Patients With Rapid Virological Response
18 April 2008
Background & Aims: This analysis reports the rate of sustained virological response (SVR) in patients infected with hepatitis C virus (HCV) genotype 1 or 4 who were assigned to 24 weeks of treatme...
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Peter Ferenci,
Hermann Laferl,
Thomas–Matthias Scherzer,
Michael Gschwantler,
Andreas Maieron,
Harald Brunner,
Rudolf Stauber,
Martin Bischof,
Bernhard Bauer,
Christian Datz,
Karin Löschenberger,
Elisabeth Formann,
Katharina Staufer,
Petra Steindl–Munda,
Austrian Hepatitis Study Group
et al.
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Full-length article
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pages 451-458
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Sustained HBeAg and HBsAg Loss After Long-term Follow-up of HBeAg-Positive Patients Treated With Peginterferon α-2b
16 May 2008
Background & Aims: The aim of this study was to evaluate the long-term sustainability of response in patients with hepatitis B e antigen (HBeAg)-positive chronic hepatitis B treated with pegylated...
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Erik H.C.J. Buster,
Hajo J. Flink,
Yilmaz Cakaloglu,
Krzysztof Simon,
Jörg Trojan,
Fehmi Tabak,
Thomas M.K. So,
S. Victor Feinman,
Tomasz Mach,
Ulus S. Akarca,
Martin Schutten,
Wanda Tielemans,
Anneke J. van Vuuren,
Bettina E. Hansen,
Harry L.A. Janssen
et al.
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Full-length article
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pages 459-467
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Donor Morbidity After Living Donation for Liver Transplantation
24 April 2008
Background & Aims: Reports of complications among adult right hepatic lobe donors have been limited to single centers. The rate and severity of complications in living donors were investigated in ...
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Rafik M. Ghobrial,
Chris E. Freise,
James F. Trotter,
Lan Tong,
Akinlolu O. Ojo,
Jeffrey H. Fair,
Robert A. Fisher,
Jean C. Emond,
Alan J. Koffron,
Timothy L. Pruett,
Kim M. Olthoff,
A2ALL Study Group
et al.
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Full-length article
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pages 468-476
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His595Tyr Polymorphism in the Methionine Synthase Reductase (MTRR) Gene Is Associated With Pancreatic Cancer Risk
23 April 2008
Background & Aims: This study attempts to elucidate a part of the genetic predisposition to the sporadic invasive ductal adenocarcinoma of the pancreas focusing on the genes implicated in the gene...
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Shumpei Ohnami,
Yasunori Sato,
Kimio Yoshimura,
Sumiko Ohnami,
Hiromi Sakamoto,
Kazunori Aoki,
Hideki Ueno,
Masafumi Ikeda,
Chigusa Morizane,
Kazuaki Shimada,
Yoshihiro Sakamoto,
Minoru Esaki,
Ikuo Saito,
Hiroshi Hirose,
Daizo Saito,
Haruhiko Sugimura,
Tomoo Kosuge,
Takuji Okusaka,
Teruhiko Yoshida
et al.
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Full-length article
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pages 477-488.e3
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| Basic - Alimentary Tract |
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Article Title |
Author(s) |
Type |
Pages |
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Analysis of Mutations in DNA Isolated From Plasma and Stool of Colorectal Cancer Patients
20 May 2008
Background & Aims: Somatic mutations provide uniquely specific markers for the early detection of neoplasia that can be detected in DNA purified from plasma or stool of patients with colorectal ca...
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Frank Diehl,
Kerstin Schmidt,
Kristine H. Durkee,
Kent J. Moore,
Steve N. Goodman,
Anthony P. Shuber,
Kenneth W. Kinzler,
Bert Vogelstein
et al.
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Full-length article
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pages 489-498.e7
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Characterization of Mutant MUTYH Proteins Associated With Familial Colorectal Cancer
08 May 2008
Background & Aims: The human mutyh gene encodes a base excision repair protein that prevents G:C to T:A transversions in DNA. Biallelic mutations in this gene are associated with recessively inher...
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Mohsin Ali,
Hyeja Kim,
Sean Cleary,
Claire Cupples,
Steven Gallinger,
Robert Bristow
et al.
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Full-length article
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pages 499-507.e1
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Constitutive CXCL12 Expression Induces Anoikis in Colorectal Carcinoma Cells
16 May 2008
Background & Aims: CXCL12 and CXCR4 signaling plays critical roles in development, homeostasis, and tumor metastasis. Previously, we have shown that epigenetic silencing of CXCL12 in colorectal an...
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Michael K. Wendt,
Luke J. Drury,
Rebecca A. Vongsa,
Michael B. Dwinell
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Full-length article
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pages 508-517.e1
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Toll-Like Receptor 5 Engagement Modulates Tumor Development and Growth in a Mouse Xenograft Model of Human Colon Cancer
24 April 2008
Background & Aims: Toll-like receptor (TLR)-dependent signaling was proposed as immunotherapeutic targets against invading pathogens and tumorigenesis. Here, we investigated whether TLR5-dependent...
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Sang Hoon Rhee,
Eunok Im,
Charalabos Pothoulakis
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Full-length article
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pages 518-528.e3
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Toll-Like Receptor Signaling in Small Intestinal Epithelium Promotes B-Cell Recruitment and IgA Production in Lamina Propria
24 April 2008
Background & Aims: Several lines of evidence support a role for Toll-like receptor (TLR) signaling to protect the intestine from pathogenic infection. We hypothesized that TLR signaling at the lev...
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Limin Shang,
Masayuki Fukata,
Nanthakumar Thirunarayanan,
Andrea P. Martin,
Paul Arnaboldi,
David Maussang,
Cecilia Berin,
Jay C. Unkeless,
Lloyd Mayer,
Maria T. Abreu,
Sergio A. Lira
et al.
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Full-length article
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pages 529-538.e1
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Raf Protects Against Colitis by Promoting Mouse Colon Epithelial Cell Survival Through NF-κB
01 May 2008
Background & Aims: Raf-1 kinase is a key regulator of a number of cellular processes, which promote the maintenance of a healthy colon epithelium. This study addresses the role of Raf in epithelia...
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Karen L. Edelblum,
M. Kay Washington,
Tatsuki Koyama,
Sylvie Robine,
Manuela Baccarini,
D. Brent Polk
et al.
|
Full-length article
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pages 539-551.e3
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TL1A (TNFSF15) Regulates the Development of Chronic Colitis by Modulating Both T-Helper 1 and T-Helper 17 Activation
08 May 2008
Background & Aims: TL1A is a tumor necrosis factor–like molecule that mediates a strong costimulation of T-helper (TH) 1 cells. Expression of TL1A is increased in the mucosa of Crohn's disease pat...
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Hidetoshi Takedatsu,
Kathrin S. Michelsen,
Bo Wei,
Carol J. Landers,
Lisa S. Thomas,
Deepti Dhall,
Jonathan Braun,
Stephan R. Targan
et al.
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Full-length article
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pages 552-567.e2
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Biostructure of Fecal Microbiota in Healthy Subjects and Patients With Chronic Idiopathic Diarrhea
23 April 2008
Background & Aims: Dysbiosis is a key component of intestinal disorders. Our aim was to quantitatively access the biostructure of fecal microbiota in healthy subjects and patients with chronic idi...
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Alexander Swidsinski,
Vera Loening–Baucke,
Hans Verstraelen,
Sylwia Osowska,
Yvonne Doerffel
et al.
|
Full-length article
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pages 568-579.e2
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Methylation of the Calcium Channel-Related Gene, CACNA2D3, Is Frequent and a Poor Prognostic Factor in Gastric Cancer
20 May 2008
Background & Aims: The calcium channel voltage-dependent α2δ subunit consists of 4 genes, CACNA2D1 to CACNA2D4, of which CACNA2D2 and CACNA2D3 are located on 3p21.3 and 3p21.1, respectively. Here,...
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Aira Wanajo,
Akane Sasaki,
Hiromi Nagasaki,
Shu Shimada,
Takeshi Otsubo,
Syuichi Owaki,
Yasufumi Shimizu,
Yoshinobu Eishi,
Kazuyuki Kojima,
Yasuaki Nakajima,
Tatsuyuki Kawano,
Yasuhito Yuasa,
Yoshimitsu Akiyama
et al.
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Full-length article
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pages 580-590.e3
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Transcription Factor Foxq1 Controls Mucin Gene Expression and Granule Content in Mouse Stomach Surface Mucous Cells
24 April 2008
Background & Aims: The gastric mucosa provides a stringent epithelial barrier and produces acid and enzymes that initiate digestion. In this regenerating tissue, progenitors differentiate continua...
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Michael P. Verzi,
Abdul H. Khan,
Susumu Ito,
Ramesh A. Shivdasani
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Full-length article
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pages 591-600
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Neurogenic Chronic Intestinal Pseudo-Obstruction: Antineuronal Antibody-Mediated Activation of Autophagy Via Fas
16 May 2008
Background & Aims: Activation of autoimmune pathways has been implicated as a contributing mechanism to the pathophysiology in some patients with chronic intestinal pseudoobstruction (CIP). In thi...
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Roberto de Giorgio,
Umberto Volta,
Vincenzo Stanghellini,
Rosanna F. Cogliandro,
Giovanni Barbara,
Roberto Corinaldesi,
Roberto Towns,
Chunfang Guo,
Shuangsong Hong,
John W. Wiley
et al.
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Full-length article
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pages 601-609
|
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Myosin Light Chain Kinase Is Central to Smooth Muscle Contraction and Required for Gastrointestinal Motility in Mice
16 May 2008
Background & Aims: Smooth muscle is essential for maintaining homeostasis for many body functions and provides adaptive responses to stresses imposed by pathologic disorders. Identified cell signa...
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Wei–Qi He,
Ya–Jing Peng,
Wen–Cheng Zhang,
Ning Lv,
Jing Tang,
Chen Chen,
Cheng–Hai Zhang,
Song Gao,
Hua–Qun Chen,
Gang Zhi,
Robert Feil,
Kristine E. Kamm,
James T. Stull,
Xiang Gao,
Min–Sheng Zhu
et al.
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Full-length article
|
pages 610-620.e2
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| Basic - Liver, Pancreas, and Biliary Tract |
| |
Article Title |
Author(s) |
Type |
Pages |
|
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Hedgehog Signaling Is Required for Effective Regeneration of Exocrine Pancreas
17 April 2008
Although both endocrine and the exocrine pancreas display a significant capacity for tissue regeneration and renewal, the existence of progenitor cells in the adult pancreas remains uncertain. Using a...
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Volker Fendrich,
Farzad Esni,
Maria Veronica R. Garay,
Georg Feldmann,
Nils Habbe,
Jan Nygaard Jensen,
Yuval Dor,
Doris Stoffers,
Jan Jensen,
Steven D. Leach,
Anirban Maitra
et al.
|
Full-length article
|
pages 621-631.e8
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|
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Direct Activation of Cytosolic Ca2+ Signaling and Enzyme Secretion by Cholecystokinin in Human Pancreatic Acinar Cells
08 May 2008
Background & Aims: Cholecystokinin (CCK) has been thought to act only indirectly on human pancreatic acinar cells via vagal nerve stimulation, rather than by direct CCK receptor activation as on r...
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John A. Murphy,
David N. Criddle,
Mark Sherwood,
Michael Chvanov,
Rajarshi Mukherjee,
Euan McLaughlin,
David Booth,
Julia V. Gerasimenko,
Michael G.T. Raraty,
Paula Ghaneh,
John P. Neoptolemos,
Oleg V. Gerasimenko,
Alexei V. Tepikin,
Gary M. Green,
Joseph R. Reeve,
Ole H. Petersen,
Robert Sutton
et al.
|
Full-length article
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pages 632-641
|
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Hepatocyte-Specific Smad7 Expression Attenuates TGF-β–Mediated Fibrogenesis and Protects Against Liver Damage
16 May 2008
Background & Aims: The profibrogenic role of transforming growth factor (TGF)-β in liver has mostly been attributed to hepatic stellate cell activation and excess matrix synthesis. Hepatocytes are...
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Steven Dooley,
Jafar Hamzavi,
Loredana Ciuclan,
Patricio Godoy,
Iryna Ilkavets,
Sabrina Ehnert,
Elke Ueberham,
Rolf Gebhardt,
Stephan Kanzler,
Andreas Geier,
Katja Breitkopf,
Honglei Weng,
Peter R. Mertens
et al.
|
Full-length article
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pages 642-659.e46
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Inhibition of Integrin αvβ6 on Cholangiocytes Blocks Transforming Growth Factor-β Activation and Retards Biliary Fibrosis Progression
17 April 2008
Background & Aims: Integrin αvβ6 is highly expressed on certain activated epithelia, where it mediates attachment to fibronectin and serves as coreceptor for the activation of latent transforming ...
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Eleonora Patsenker,
Yury Popov,
Felix Stickel,
Alfred Jonczyk,
Simon L. Goodman,
Detlef Schuppan
et al.
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Full-length article
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pages 660-670
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Platelet-Derived Growth Factor Signaling Through Ephrin-B2 Regulates Hepatic Vascular Structure and Function
17 April 2008
Background & Aims: Cirrhosis is associated with prominent changes in sinusoidal structure and function. Although the resident pericyte in liver, the hepatic stellate cell (HSC), is well characteri...
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David Semela,
Amitava Das,
Daniel Langer,
Ningling Kang,
Edward Leof,
Vijay Shah
et al.
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Full-length article
|
pages 671-679.e2
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Copper Availability Contributes to Iron Perturbations in Human Nonalcoholic Fatty Liver Disease
17 April 2008
Background & Aims: Iron perturbations are frequently observed in nonalcoholic fatty liver disease (NAFLD). We aimed to investigate a potential association of copper status with disturbances of iro...
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Elmar Aigner,
Igor Theurl,
Heike Haufe,
Markus Seifert,
Florian Hohla,
Ludwig Scharinger,
Felix Stickel,
Frederic Mourlane,
Günter Weiss,
Christian Datz
et al.
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Full-length article
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pages 680-688.e1
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Regulation of Bile Acid Synthesis by the Nuclear Receptor Rev-erbα
16 May 2008
Background & Aims: Conversion into bile acids represents an important route to remove excess cholesterol from the body. Rev-erbα is a nuclear receptor that participates as one of the clock genes i...
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Hélène Duez,
Jelske N. van der Veen,
Christian Duhem,
Benoît Pourcet,
Thierry Touvier,
Coralie Fontaine,
Bruno Derudas,
Eric Baugé,
Rick Havinga,
Vincent W. Bloks,
Henk Wolters,
Fjodor H. van der Sluijs,
Björn Vennström,
Folkert Kuipers,
Bart Staels
et al.
|
Full-length article
|
pages 689-698.e5
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| Continuing Medical Education (CME) Activities |
| |
Article Title |
Author(s) |
Type |
Pages |
|
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Continuing Medical Education Exam 1: August 2008
10 July 2008
|
Michael B. Wallace
|
Examination
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page 699
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Continuing Medical Education Exam 2: August 2008
10 July 2008
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Examination
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pages 700-701
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| Selected Summaries |
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Article Title |
Author(s) |
Type |
Pages |
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Statins Are Safe for the Treatment of Hypercholesterolemia in Patients With Chronic Liver Disease
11 July 2008
Lewis JH, Mortensen ME, Zweig S, et al. (Georgetown University Medical Center, Washington, DC, USA). Efficacy and safety of high-dose pravastatin in hypercholesterolemic patients with well-compensated...
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Saleh A. Alqahtani,
William Sanchez
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Discussion
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pages 702-704
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Cigarette Smoking and Colorectal Cancer Risk: A Burning Issue
10 July 2008
Paskett ED, Reeves KW, Rohan TE, et al. (Division of Public Sciences, Center for Population Health and Health Disparities, and School of Public Health, The Ohio State University, Columbus, Ohio.) Asso...
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David Limsui,
Paul J. Limburg
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Discussion
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pages 704-705
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A New Twist in the Cholesterol Metabolism-Based Enterohepatic Connection
11 July 2008
Brown JM, Bell TA 3rd, Alger HM, et al. (Department of Pathology, Wake Forest University School of Medicine, Winston-Salem, North Carolina). Targeted depletion of hepatic ACAT2-driven cholesterol este...
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Flavio Nervi,
Silvana Zanlungo,
Attilio Rigotti
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Discussion
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pages 705-706
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| Print and Media Reviews |
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Article Title |
Author(s) |
Type |
Pages |
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Book review
11 July 2008
It should come as no surprise to the readers of this journal that most gastroenterologists do not receive enough instruction in their subspecialty training to answer many of the questions they encount...
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Douglas L. Seidner
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Book review
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page 707
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Book review
04 July 2008
Textbook of Hepatology: From Basic Science to Clinical Practice is designed to be a state-of-the-art, comprehensive review of clinical hepatology. The 2-volume text covers both common liver problems a...
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Keith D. Lindor
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Book review
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page 708
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Book review
11 July 2008
This is the fourth in a series of monographs edited by Charles Bernstein, MD, from the University of Manitoba examining select topics related to the care of inflammatory bowel disease (IBD) patients. ...
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Bret A. Lashner
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Book review
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pages 708-709
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| Correspondence |
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Article Title |
Author(s) |
Type |
Pages |
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Screening and Surveillance for the Early Detection of Colorectal Cancer and Adenomatous Polyps
10 July 2008
We read with interest the revised guideline from the American Cancer Society, the US Multi-Society Task Force on Colorectal Cancer, and the American College of Radiology which represents an important ...
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Patrick Maisonneuve,
Edoardo Botteri,
Albert B. Lowenfels
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Correspondence
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page 710
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Reply
10 July 2008
Maisonneuve, Botteri, and Lowenfels raise an interesting question about “customized” colorectal cancer (CRC) screening. They correctly cite data that men (compared with women) and smokers have an incr...
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David Lieberman,
Bernard Levin,
Beth McFarland,
Durado Brooks,
Robert Smith
et al.
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Correspondence
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pages 710-711
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Immune Response Against Frameshift-Induced Neopeptides in HNPCC Patients and Healthy HNPCC Mutation Carriers
10 July 2008
The manuscript by Schwitalle et al has initiated a welcome new interest on immune responses against frameshift-induced neopeptides in microsatellite instable (MSI-H [colorectal]) cancer and potential ...
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Frank M. Speetjens,
Peter J.K. Kuppen,
Hans Morreau,
Sjoerd H. van der Burg
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Correspondence
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pages 711-712
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Reply
10 July 2008
Microsatellite unstable (MSI-H) colorectal cancers (CRC) display strong infiltration by immune cells and display characteristic clinical features, suggesting that the pathogenesis of these tumors is a...
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Yvette Schwitalle,
Magnus von Knebel Doeberitz,
Matthias Kloor
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Correspondence
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pages 712-713
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