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Cover 1
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Miscellaneous
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page OFC
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| This Month in Gastroenterology |
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This Month in Gastroenterology
The pathophysiology of irritable bowel syndrome (IBS) remains elusive, but increasing evidence for disordered serotonin signaling in the gastrointestinal tract was presented over the last few years. P...
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Jan Tack,
John M. Carethers
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Discussion
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pages 1-3
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| Gastroenterology and Hepatology News |
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Study Points to Increased Colorectal Cancer Screening Among Veteran’s Affairs Patients
The rate of colorectal cancer screening appears to be increasing among Veterans Affairs (VA) patients, although the use of colonoscopy is less common than other screening procedures, according to a re...
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Les Lang
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Full-length article
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pages 4-5
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Study Identifies a Gene for Inflammatory Bowel Disease
In a multicenter study aimed at identifying genetic factors that might contribute to inflammatory bowel disease (IBD), researchers led by Dr Richard H. Duerr, Associate Professor of Medicine at the Un...
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Les Lang
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Full-length article
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page 5
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Combination Therapy With Telaprevir and Pegylated Interferon Suppresses Both Wild-Type and Resistant Hepatitis C Virus
New clinical research presented at the 57th Annual Meeting of the American Association for the Study of Liver Diseases in October suggests that both wild-type hepatitis C virus (HCV) and resistant var...
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Les Lang
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Full-length article
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pages 5-6
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Keith Lindor is New Editor-In-Chief of Hepatology
The new Editor-in-Chief of Hepatology is Dr Keith Lindor (), Dean of the Mayo Medical School and Professor of Medicine in the Division of Gastroenterology and Hepatology at the Mayo Clinic College of ...
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Les Lang
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Full-length article
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pages 6-7
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| Comment From the Editor |
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Translational Research: The Study of Community Effectiveness in Digestive and Liver Disorders
A recent report from the Institute of Medicine concluded that, “In its current form, habits, and environment, American health care is incapable of providing the public with the quality health care it ...
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Hashem B. El-Serag
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Editorial
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pages 8-10
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| Biographical Sketch |
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Kelly of the Kelly Clamp
08 January 2007
Howard Atwood Kelly (1858–1943) was born in Camden, New Jersey, and raised in Philadelphia by his family steeped in the fervent religious tradition of the Methodist Episcopal Church. He earned his un...
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William S. Haubrich
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Personal report
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page 10
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| Imaging and Advanced Technology |
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Molecular Imaging in Gastrointestinal Disease
Imaging of gastrointestinal processes may be divided into 2 broad categories. Direct visualization by optical means has typically been performed by gastroenterologists using minimally invasive endosco...
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Umar Mahmood,
Michael B. Wallace
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Full-length article
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pages 11-14
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| Clinical Challenges and Images in GI |
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Clinical Challenges and Images in GI
Question: A 62-year-old woman presented with a 2-week history of intermittent right upper quadrant biliary pain. No abnormalities were noted on clinical examination. Laboratory examinations showed a w...
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Hans Orlent,
Dominik Selleslag,
Stefaan Vandecasteele
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Discussion
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pages 15-16
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Clinical Challenges and Images in GI
Question: A 32-year-old woman presented with upper abdominal pain radiating to her back, progressively increasing over 3 days associated with a few episodes of vomiting. She had intermittent mild pain...
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Prasun Kumar Jalal,
Simmy Bank,
John Hines
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Discussion
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page 16
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| Clinical - Alimentary Tract |
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Alterations in Expression of p11 and SERT in Mucosal Biopsy Specimens of Patients With Irritable Bowel Syndrome
23 November 2006
Background & Aims: The pathophysiology of irritable bowel syndrome (IBS) remains enigmatic; abnormalities in serotonin metabolism have been implicated. Two proteins that influence the function of ...
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Michael Camilleri,
Christopher N. Andrews,
Adil E. Bharucha,
Paula J. Carlson,
Irene Ferber,
Debra Stephens,
Thomas C. Smyrk,
Raul Urrutia,
Jeroen Aerssens,
Leen Thielemans,
Hinrich Göhlmann,
Ilse van den Wyngaert,
Bernard Coulie
et al.
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Full-length article
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pages 17-25
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Mast Cell-Dependent Excitation of Visceral-Nociceptive Sensory Neurons in Irritable Bowel Syndrome
Background & Aims: Intestinal mast cell infiltration may participate to abdominal pain in irritable bowel syndrome (IBS) patients. However, the underlying mechanisms remain unknown. We assessed th...
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Giovanni Barbara,
Bingxian Wang,
Vincenzo Stanghellini,
Roberto de Giorgio,
Cesare Cremon,
Giovanni Di Nardo,
Marcello Trevisani,
Barbara Campi,
Pierangelo Geppetti,
Marcello Tonini,
Nigel W. Bunnett,
David Grundy,
Roberto Corinaldesi
et al.
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Full-length article
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pages 26-37
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Bowel Urgency in Patients With Irritable Bowel Syndrome
02 November 2006
Background & Aims: Bowel urgency is the most bothersome symptom in irritable bowel syndrome patients with diarrhea, but its pathophysiology is poorly understood. Our aim was to assess the relation...
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Guido Basilisco,
Elisabetta De Marco,
Carolina Tomba,
Bruno Mario Cesana
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Full-length article
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pages 38-44
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Chronic Intestinal Pseudo-Obstruction due to Buserelin-Induced Formation of Anti-GnRH Antibodies
Background & Aims: A 30-year-old woman, treated with buserelin, an analogue of gonadotropin-releasing hormone (GnRH) (also called luteinizing hormone-releasing hormone, LH-RH), developed chronic i...
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Bodil Ohlsson,
Béla Veress,
Sabina Janciauskiene,
Agneta Montgomery,
Monica Haglund,
Anders Wallmark
et al.
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Full-length article
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pages 45-51
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 Adalimumab for Maintenance of Clinical Response and Remission in Patients With Crohn’s Disease: The CHARM Trial
06 December 2006
Background & Aims: This study evaluated the efficacy and safety of adalimumab, a fully human, anti–tumor necrosis factor monoclonal antibody administered subcutaneously, in the maintenance of resp...
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Jean–Frédéric Colombel,
William J. Sandborn,
Paul Rutgeerts,
Robert Enns,
Stephen B. Hanauer,
Remo Panaccione,
Stefan Schreiber,
Dan Byczkowski,
Ju Li,
Jeffrey D. Kent,
Paul F. Pollack
et al.
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Full-length article
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pages 52-65
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 Once-Daily, High-Concentration MMX Mesalamine in Active Ulcerative Colitis
18 October 2006
Background & Aims: SPD476 (LIALDA™ in the US; MEZAVANT™ in the EU; otherwise known as MMX mesalamine; Shire Pharmaceuticals Inc., Wayne, PA, under license from Giuliani SpA, Milan, Italy) is a nov...
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Michael A. Kamm,
William J. Sandborn,
Miguel Gassull,
Stefan Schreiber,
Lechoslaw Jackowski,
Todd Butler,
Andrew Lyne,
David Stephenson,
Mary Palmen,
Raymond E. Joseph
et al.
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Full-length article
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pages 66-75
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 A Randomized, Placebo-Controlled, Phase II Study of Tetomilast in Active Ulcerative Colitis
23 November 2006
Background & Aims: Tetomilast (OPC-6535), a novel thiazole compound, inhibits phosphodiesterase-4 and proinflammatory functions of leukocytes including superoxide production and cytokine release. ...
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Stefan Schreiber,
Ali Keshavarzian,
Kim L. Isaacs,
John Schollenberger,
Juan P. Guzman,
Cesare Orlandi,
Stephen B. Hanauer
et al.
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Full-length article
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pages 76-86
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Lifestyle Factors and Risk for Symptomatic Gastroesophageal Reflux in Monozygotic Twins
20 November 2006
Background & Aims: Lifestyle and genetic factors dominate the etiology of gastroesophageal reflux disease. We investigated associations between lifestyle factors and gastroesophageal reflux (GER) ...
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Zongli Zheng,
Helena Nordenstedt,
Nancy L. Pedersen,
Jesper Lagergren,
Weimin Ye
et al.
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Full-length article
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pages 87-95
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Rates of New or Missed Colorectal Cancers After Colonoscopy and Their Risk Factors: A Population-Based Analysis
Background & Aims: The rate of new or missed colorectal cancer (CRC) after colonoscopy and their risk factors in usual practice are unknown. Our objective was to evaluate the rate and risk factors...
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Brian Bressler,
Lawrence F. Paszat,
Zhongliang Chen,
Deanna M. Rothwell,
Chris Vinden,
Linda Rabeneck
et al.
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Full-length article
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pages 96-102
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| Clinical - Liver, Pancreas, and Biliary Tract |
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 Impact of Reducing Peginterferon Alfa-2a and Ribavirin Dose During Retreatment in Patients With Chronic Hepatitis C
14 November 2006
Background & Aims: Reducing the dose of peginterferon and/or ribavirin to <80% when treating chronic hepatitis C virus has been associated with a reduction in sustained virologic response (SVR)...
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Mitchell L. Shiffman,
Marc G. Ghany,
Timothy R. Morgan,
Elizabeth C. Wright,
Gregory T. Everson,
Karen L. Lindsay,
Anna S.F. Lok,
Herbert L. Bonkovsky,
Adrian M. Di Bisceglie,
William M. Lee,
Jules L. Dienstag,
David R. Gretch,
HALT-C Trial Group
et al.
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Full-length article
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pages 103-112
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Methionine and Vitamin B6 Intake and Risk of Pancreatic Cancer: A Prospective Study of Swedish Women and Men
18 October 2006
Background & Aims: It has been hypothesized that dietary factors involved in methyl group metabolism, such as methionine, folate, and vitamin B6, may modify cancer risk. We have previously reporte...
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Susanna C. Larsson,
Edward Giovannucci,
Alicja Wolk
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Full-length article
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pages 113-118
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Novel Resequencing Chip Customized to Diagnose Mutations in Patients With Inherited Syndromes of Intrahepatic Cholestasis
27 October 2006
Background & Aims: Inherited syndromes of intrahepatic cholestasis commonly result from mutations in the genes SERPINA1 (α1-antitrypsin deficiency), JAG1 (Alagille syndrome), ATP8B1 (progressive f...
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Cong Liu,
Bruce J. Aronow,
Anil G. Jegga,
Ning Wang,
Alex Miethke,
Reena Mourya,
Jorge A. Bezerra
et al.
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Full-length article
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pages 119-126
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| Basic - Alimentary Tract |
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Article Title |
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The CpG Island Methylator Phenotype and Chromosomal Instability Are Inversely Correlated in Sporadic Colorectal Cancer
26 September 2006
Background & Aims: The CpG island methylator phenotype (CIMP) is one of the mechanisms involved in colorectal carcinogenesis (CRC). Although CIMP is probably the cause of high-frequency microsatel...
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Ajay Goel,
Takeshi Nagasaka,
Christian N. Arnold,
Toru Inoue,
Cody Hamilton,
Donna Niedzwiecki,
Carolyn Compton,
Robert J. Mayer,
Richard Goldberg,
Monica M. Bertagnolli,
C. Richard Boland
et al.
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Full-length article
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pages 127-138
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Enhanced Recruitment of CX3CR1+ T Cells by Mucosal Endothelial Cell–Derived Fractalkine in Inflammatory Bowel Disease
18 October 2006
Background & Aims: Fractalkine (FKN/CX3CL1) is a unique chemokine combining adhesive and chemotactic properties. We investigated FKN production by the mucosal microvasculature in inflammatory bowe...
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Miquel Sans,
Silvio Danese,
Carol de la Motte,
Heitor S.P. de Souza,
Brenda M. Rivera–Reyes,
Gail A. West,
Manijeh Phillips,
Jeffry A. Katz,
Claudio Fiocchi
et al.
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Full-length article
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pages 139-153
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Gastroesophageal Reflux Disease–Associated Esophagitis Induces Endogenous Cytokine Production Leading to Motor Abnormalities
18 October 2006
Background & Aims: Gastroesophageal reflux disease is a condition frequently associated with esophagitis and motor abnormalities. Recent evidence suggests that proinflammatory cytokines, such as i...
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Florian Rieder,
Ling Cheng,
Karen M. Harnett,
Amitabh Chak,
Gregory S. Cooper,
Gerard Isenberg,
Monica Ray,
Jeffry A. Katz,
Andrew Catanzaro,
Robert O’Shea,
Anthony B. Post,
Richard Wong,
Michael V. Sivak,
Thomas McCormick,
Manijeh Phillips,
Gail A. West,
Joseph E. Willis,
Piero Biancani,
Claudio Fiocchi
et al.
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Full-length article
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pages 154-165
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A Functional Role for Interleukin-21 in Promoting the Synthesis of the T-Cell Chemoattractant, MIP-3α, by Gut Epithelial Cells
04 October 2006
Background & Aims: Interleukin (IL)-21, a T-cell–derived cytokine, is produced in excess in inflammatory bowel diseases (IBD). The IL-21 receptor (IL-21R) is expressed by immune and nonimmune cell...
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Roberta Caruso,
Daniele Fina,
Ilaria Peluso,
Carmine Stolfi,
Massimo Claudio Fantini,
Valentina Gioia,
Flavio Caprioli,
Giovanna Del Vecchio Blanco,
Omero Alessandro Paoluzi,
Thomas T. MacDonald,
Francesco Pallone,
Giovanni Monteleone
et al.
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Full-length article
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pages 166-175
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Bone Marrow Retaining Colitogenic CD4+ T Cells May Be a Pathogenic Reservoir for Chronic Colitis
02 November 2006
Background & Aims: Although bone marrow (BM) is known as a primary lymphoid organ, it also is known to harbor memory T cells, suggesting that this compartment is a preferential site for migration ...
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Yasuhiro Nemoto,
Takanori Kanai,
Shin Makita,
Ryuichi Okamoto,
Teruji Totsuka,
Kiyoshi Takeda,
Mamoru Watanabe
et al.
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Full-length article
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pages 176-189
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Interleukin-10 Blocked Endoplasmic Reticulum Stress in Intestinal Epithelial Cells: Impact on Chronic Inflammation
27 October 2006
Background & Aims: The initiation of endoplasmic reticulum (ER)-mediated stress responses in intestinal epithelial cells (IEC) may contribute to the pathogenesis of chronic intestinal inflammation...
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Anna Shkoda,
Pedro A. Ruiz,
Hannelore Daniel,
Sandra C. Kim,
Gerhard Rogler,
R. Balfour Sartor,
Dirk Haller
et al.
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Full-length article
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pages 190-207
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Reciprocal Targeting of Hath1 and β-Catenin by Wnt Glycogen Synthase Kinase 3β in Human Colon Cancer
27 October 2006
Background & Aims: The transcription factor Hath1 plays a crucial role in the differentiation program of the human gut epithelium. The present study was conducted to investigate the molecular mech...
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Kiichiro Tsuchiya,
Tetsuya Nakamura,
Ryuichi Okamoto,
Takanori Kanai,
Mamoru Watanabe
et al.
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Full-length article
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pages 208-220
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5-ASA Affects Cell Cycle Progression in Colorectal Cells by Reversibly Activating a Replication Checkpoint
18 October 2006
Background & Aims: Individuals with inflammatory bowel disease are at risk of developing colorectal cancer (CRC). Epidemiologic, animal, and laboratory studies suggest that 5-amino-salicylic acid ...
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M. Gloria Luciani,
Christoph Campregher,
John M. Fortune,
Thomas A. Kunkel,
Christoph Gasche
et al.
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Full-length article
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pages 221-235
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Butyrate Induces Intestinal Sodium Absorption via Sp3-Mediated Transcriptional Up-Regulation of Epithelial Sodium Channels
Background & Aims: The epithelial sodium channel (ENaC) is the rate-limiting factor for colonic electrogenic sodium absorption. This study aimed to investigate ENaC regulation by butyrate, a short...
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Sebastian Zeissig,
Anja Fromm,
Joachim Mankertz,
Jörg Weiske,
Martin Zeitz,
Michael Fromm,
Jörg–Dieter Schulzke
et al.
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Full-length article
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pages 236-248
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Actions by Angiotensin II on Esophageal Contractility in Humans
14 November 2006
Background & Aims: Angiotensin II is a potent activator of smooth muscles but has not been much investigated with regard to gastrointestinal motor activity. This study explores expression of the r...
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Anna Casselbrant,
Anders Edebo,
Johanna Wennerblom,
Hans Lönroth,
Herbert F. Helander,
Michael Vieth,
Lars Lundell,
Lars Fändriks
et al.
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Full-length article
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pages 249-260
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Gastrointestinal Safety and Anti-Inflammatory Effects of a Hydrogen Sulfide–Releasing Diclofenac Derivative in the Rat
06 December 2006
Background & Aims: Gastrointestinal damage caused by nonsteroidal anti-inflammatory drugs (NSAIDs) remains a significant clinical problem. Hydrogen makes an important contribution to mucosal defen...
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John L. Wallace,
Giuseppe Caliendo,
Vincenzo Santagada,
Giuseppe Cirino,
Stefano Fiorucci
et al.
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Full-length article
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pages 261-271
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| Basic - Liver, Pancreas, and Biliary Tract |
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Genetic Susceptibility to Diclofenac-Induced Hepatotoxicity: Contribution of UGT2B7, CYP2C8, and ABCC2 Genotypes
23 November 2006
Background & Aims: Diclofenac is a widely used nonsteroidal anti-inflammatory drug and is among the most common drugs causing idiosyncratic hepatotoxicity in several recent series with up to 20% m...
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Ann K. Daly,
Guruprasad P. Aithal,
Julian B.S. Leathart,
Richard A. Swainsbury,
Tarana Singh Dang,
Christopher P. Day
et al.
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Full-length article
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pages 272-281
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Insulin Resistance Accelerates a Dietary Rat Model of Nonalcoholic Steatohepatitis
18 October 2006
Background & Aims: The increasing prevalence of nonalcoholic steatohepatitis (NASH) is due to the epidemic of obesity and type 2 diabetes, both of which are associated with insulin resistance. Met...
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Tsuguhito Ota,
Toshinari Takamura,
Seiichiro Kurita,
Naoto Matsuzawa,
Yuki Kita,
Masafumi Uno,
Hiroshi Akahori,
Hirofumi Misu,
Masaru Sakurai,
Yoh Zen,
Yasuni Nakanuma,
Shuichi Kaneko
et al.
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Full-length article
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pages 282-293
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STAT3 Is Required for IL-6-gp130–Dependent Activation of Hepcidin In Vivo
24 October 2006
Background & Aims: Hepcidin is a peptide hormone that is central to the regulation of iron homeostasis. In response to interleukin 6 (IL-6), hepatocytes produce hepcidin that decreases iron releas...
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Antonello Pietrangelo,
Uta Dierssen,
Linda Valli,
Cinzia Garuti,
Agrani Rump,
Elena Corradini,
Matthias Ernst,
Christian Klein,
Christian Trautwein
et al.
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Full-length article
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pages 294-300
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Targeted Disruption of the Hepatic Transferrin Receptor 2 Gene in Mice Leads to Iron Overload
23 November 2006
Background & Aims: Transferrin receptor 2 (TfR2) plays a key role in the regulation of iron metabolism. Mutations of TfR2 in humans cause type 3 hereditary hemochromatosis. Although highly express...
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Daniel F. Wallace,
Lesa Summerville,
V. Nathan Subramaniam
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Full-length article
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pages 301-310
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A Cell-Based, High-Throughput Screen for Small Molecule Regulators of Hepatitis C Virus Replication
27 October 2006
Background & Aims: Only half of patients with chronic hepatitis C virus (HCV) infection experience sustained virologic response to pegylated-interferon and ribavirin, which cause numerous side eff...
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Sun Suk Kim,
Lee F. Peng,
Wenyu Lin,
Won-Hyeok Choe,
Naoya Sakamoto,
Stuart L. Schreiber,
Raymond T. Chung
et al.
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Full-length article
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pages 311-320
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Prolonged Survival of Porcine Hepatocytes in Cynomolgus Monkeys
18 October 2006
Background & Aims: Management of patients with liver failure can be a significant medical challenge, and transplantation of the liver is the only definitive therapy. Whole liver allotransplantatio...
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Hideo Nagata,
Ryuta Nishitai,
Chiyoe Shirota,
Jia-Lin Zhang,
Cody A. Koch,
Jin Cai,
Michel Awwad,
Henk-Jan Schuurman,
Uwe Christians,
Michio Abe,
Janina Baranowska–Kortylewicz,
Jeffrey L. Platt,
Ira J. Fox
et al.
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Full-length article
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pages 321-329
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Characterization of HULC, a Novel Gene With Striking Up-Regulation in Hepatocellular Carcinoma, as Noncoding RNA
14 August 2006
Background & Aims: Recent studies have highlighted the role of noncoding RNAs (ncRNAs) in carcinogenesis, and suggested that this class of genes might be used as biomarkers in cancer. We searched ...
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Katrin Panzitt,
Marisa M.O. Tschernatsch,
Christian Guelly,
Tarek Moustafa,
Martin Stradner,
Heimo M. Strohmaier,
Charles R. Buck,
Helmut Denk,
Renée Schroeder,
Michael Trauner,
Kurt Zatloukal
et al.
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Full-length article
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pages 330-342
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Large Hepatitis Delta Antigen Modulates Transforming Growth Factor-β Signaling Cascades: Implication of Hepatitis Delta Virus–Induced Liver Fibrosis
02 November 2006
Background & Aims: Transforming growth factor-β (TGF-β) has been implicated in the pathogenesis of liver disease. TGF-β is involved in liver regeneration and in the fibrotic and cirrhotic transfor...
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Soo–Ho Choi,
Sook–Hyang Jeong,
Soon B. Hwang
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Full-length article
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pages 343-357
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IL-28A Is a Key Regulator of T-Cell–Mediated Liver Injury via the T-Box Transcription Factor T-Bet
27 October 2006
Background & Aims: T-cell–mediated fulminant hepatitis is a potentially life-threatening event for which the underlying pathogenic mechanisms are not fully understood. Here, we demonstrate a key r...
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Juergen Siebler,
Stefan Wirtz,
Benno Weigmann,
Imke Atreya,
Edgar Schmitt,
Andreas Kreft,
Peter R. Galle,
Markus F. Neurath
et al.
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Full-length article
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pages 358-371
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Mild Hypothermia Attenuates Liver Injury and Improves Survival in Mice With Acetaminophen Toxicity
23 November 2006
Background & Aims: Body temperature may critically affect mechanisms of liver injury in acetaminophen (APAP) hepatotoxicity. In addition, mild hypothermia is used to treat intracranial hypertensio...
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Javier Vaquero,
Mireille Bélanger,
Laura James,
Raquel Herrero,
Paul Desjardins,
Jean Côté,
Andres T. Blei,
Roger F. Butterworth
et al.
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Full-length article
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pages 372-383
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Sustained IL-6/STAT-3 Signaling in Cholangiocarcinoma Cells Due to SOCS-3 Epigenetic Silencing
10 November 2006
Background & Aims: Interleukin 6 (IL-6)-mediated signal transducers and activators of transcription 3 (STAT-3) phosphorylation (activation) is aberrantly sustained in cholangiocarcinoma cells resu...
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Hajime Isomoto,
Justin L. Mott,
Shogo Kobayashi,
Nathan W. Werneburg,
Steve F. Bronk,
Serge Haan,
Gregory J. Gores
et al.
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Full-length article
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pages 384-396
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| Reviews in Basic and Clinical Gastroenterology |
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The Serotonin Signaling System: From Basic Understanding To Drug Development for Functional GI Disorders
Serotonin is an important gastrointestinal signaling molecule. It is a paracrine messenger utilized by enterochromaffin (EC) cells, which function as sensory transducers. Serotonin activates intrinsic...
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Michael D. Gershon,
Jan Tack
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Full-length article
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pages 397-414
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| Special Reports and Reviews |
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 Proliferating Cholangiocytes: A Neuroendocrine Compartment in the Diseased Liver
25 July 2006
In the last 15 years, the intrahepatic biliary tree has become the object of extensive studies, which highlighted the extraordinary biologic properties of cholangiocytes involved in bile formation, pr...
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Domenico Alvaro,
Maria Grazia Mancino,
Shannon Glaser,
Eugenio Gaudio,
Marco Marzioni,
Heather Francis,
Gianfranco Alpini
et al.
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Full-length article
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pages 415-431
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| Continuing Medical Education (CME) Activities |
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Article Title |
Author(s) |
Type |
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Continuing Medical Education Exam 1: January 2007
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Michael B. Wallace
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Examination
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pages 432-433
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Continuing Medical Education Exam 2: January 2007
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Michael B. Wallace
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Examination
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page 433
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| Perspective |
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Article Title |
Author(s) |
Type |
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State of Pediatric Gastroenterology, Hepatology, and Nutrition: 2006 and Beyond
Pediatric gastroenterology, hepatology, and nutrition are vital components of our clinical practices, in the education and training of future leaders, and in bringing discoveries from the laboratory t...
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W. Allan Walker,
Philip Sherman,
Mitchell Cohen,
John Barnard
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Full-length article
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pages 434-436
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| Editorials |
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Article Title |
Author(s) |
Type |
Pages |
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Searching for the Answer to Irritable Bowel Syndrome in the Colonic Mucosa: SERTainty and UnSERTainty
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Robin Spiller,
Andrew Bennett
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Editorial
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pages 437-441
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Methionine Intake and Pancreatic Cancer Risk: Digesting the Evidence
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Albert B. Lowenfels,
Patrick Maisonneuve
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Editorial
|
pages 441-443
|
|
|
Insulin Resistance: Cause or Consequence of Nonalcoholic Steatohepatitis?
|
Rexford S. Ahima
|
Editorial
|
pages 444-446
|
|
|
Hepcidin Activation During Inflammation: Make It STAT
|
Robert E. Fleming
|
Editorial
|
pages 447-449
|
|
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Hog Heaven on the Road to Liver Cell Therapy
|
Sanjeev Gupta
|
Editorial
|
pages 450-453
|
| Selected Summaries |
| |
Article Title |
Author(s) |
Type |
Pages |
|
|
Keeping harmful intruders at bay: Insights into the mechanism of barrier dysfunction during inflammatory bowel diseases
Blair SA, Kane SV, Clayburgh DR, Turner J. (Department of Pathology, The University of Chicago, Chicago, Illinois). Epithelial myosin light chain kinase expression and activity are upregulated in infl...
|
Arianne L. Theiss,
Didier Merlin,
Shanthi V. Sitaraman
|
Discussion
|
pages 454-455
|
|
|
Reply
We greatly appreciate these comments regarding our recent work and share the enthusiasm of Drs Theiss, Merlin, and Sitaraman regarding the long-term potential of these mechanistic insights to lead to ...
|
Jerrold R. Turner,
Stephanie A. Blair,
Sunanda V. Kane,
Daniel R. Clayburgh
|
Discussion
|
pages 455-456
|
|
|
Physical activity and colorectal cancer survival: The more METS the better
Meyerhardt JA, Giovannucci EL, Chan AT, Chan JA, Colditz GA, Fuchs CS. (Dana-Farber Cancer Institute, Brigham and Women’s Hospital, and Massachusetts General Hospital). Physical activity and survival ...
|
Arati Pratap,
Paul C. Schroy
|
Discussion
|
pages 456-458
|
|
|
Irritable bowel syndrome: A chronic sequelae of acute gastroenteritis
Halvorson HA, Schlett CD, Riddle MS. (Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland). Postinfectious irritable bowel syndro...
|
Christina M. Surawicz,
Crenguta Stepan
|
Discussion
|
pages 458-460
|
