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Cover 1
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Miscellaneous
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page CO1
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| This Month in Gastroenterology |
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This Month in Gastroenterology
In view of the high prevalence of functional gastrointestinal disorders, clinicians who are confronted with gastrointestinal symptoms in daily practice need to decide whether or not they need to pursu...
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Jan Tack,
John M. Carethers
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Discussion
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pages 339-341
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| Gastroenterology and Hepatology News |
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Study Finds Racial Differences in Response to Treatments for Advanced Colon Cancer
In recent years, reports have emerged showing that Americans with colorectal cancer who are black have a lower rate of survival compared with other racial groups.
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Richard Peek
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Full-length article
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pages 342-343
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ACE Inhibitors May Reduce Esophageal Cancer Incidence
New research presented in Los Angeles at Digestive Disease Week 2006 (DDW) indicates that ACE inhibitors not only effectively lower blood pressure, but they also may be associated with a significant d...
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Les Lang
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Full-length article
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pages 343-344
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Late Onset Wilson Disease Frequently Overlooked
Wilson disease (WD) is a rare autosomal recessive inherited disorder of copper metabolism and is characterized by excessive deposition of copper in the liver, brain, and other tissues. It’s frequency ...
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K. Rajender Reddy
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Full-length article
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page 343
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Caspase Activity a Novel Biomarker for NAFLD Severity
In patients with nonalcoholic fatty liver disease (NAFLD), a liver biopsy remains the only reliable way to differentiate simple steatosis from nonalcoholic steatohepatitis (NASH) and determine the sta...
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Les Lang
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Full-length article
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page 344
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| Comment from the Editors |
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On Being a Mentor in Today’s Environment
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Gary D. Wu
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Editorial
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pages 345-346
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| Imaging and Advanced Technology |
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Leeuwenhoek Meets Kussmaul: The Evolution of Endoscopist to Endo-Pathologist
From the first indirect optical endospection of the stomach by Kussmaul in 1868 to the recent past, endoscopy has been largely a direct extension of the physical examination. As internists and gastroe...
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Michael B. Wallace
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Full-length article
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pages 347-349
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| Biographical sketch |
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Mann and Williamson of the Mann–Williamson preparation
Frank C. Mann (1887–1962) () was born on a farm in Adams County, Indiana. His rural upbringing fostered a lifelong and abiding interest in nature: the breeding of livestock and the culture of dahlias ...
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William S. Haubrich
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Personal report
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page 349
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| Clinical Challenges and Images in GI |
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Clinical Challenges and Images in GI: David A. Katzka and David L. Jaffe, Section Editors
Question: A 66-year-old white man presented with episodic abdominal pain for 6 months. He also complained of occasional bloating and watery diarrhea. He denied any weight loss, nausea, vomiting, or ch...
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Samuel Davidoff,
Angelo Fernandes,
Kostas Sideridis,
Gary Gecelter,
Jeremy Bragdon,
Simmy Bank
et al.
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Discussion
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page 350
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Clinical Challenges and Images in GI
Question: A 64-year-old man presented with the sudden onset of severe abdominal pain. He had no previous medical history. He was afebrile and his blood pressure was 120/75 mm Hg. Physical examination ...
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Norimitsu Uza,
Hiroshi Nakase,
Tsutomu Chiba
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Discussion
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page 351
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| Clinical - Alimentary Tract |
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Longitudinal Change in Perceptual and Brain Activation Response to Visceral Stimuli in Irritable Bowel Syndrome Patients
Background & Aims: Symptom-related fears and associated hypervigilance toward visceral stimuli may play a role in central pain amplification and irritable bowel syndrome (IBS) pathophysiology. Rep...
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Bruce D. Naliboff,
Steve Berman,
Brandall Suyenobu,
Jennifer S. Labus,
Lin Chang,
Jean Stains,
Mark A. Mandelkern,
Emeran A. Mayer
et al.
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Full-length article
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pages 352-365
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Antibodies Against Laminaribioside and Chitobioside Are Novel Serologic Markers in Crohn’s Disease
Background & Aims: New serologic markers of inflammatory bowel disease may be useful for differentiating between Crohn’s disease and ulcerative colitis and for disease stratification. We profiled ...
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Iris Dotan,
Sigal Fishman,
Yaara Dgani,
Mikael Schwartz,
Amir Karban,
Aaron Lerner,
Oori Weishauss,
Larissa Spector,
Avi Shtevi,
Rom T. Altstock,
Nir Dotan,
Zamir Halpern
et al.
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Full-length article
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pages 366-378
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Laterally Spreading Type of Colorectal Adenoma Exhibits a Unique Methylation Phenotype and K-ras Mutations
Background & Aims: Laterally spreading tumors (LST), characterized by superficial extension along the colonic lumen, have recently been detected by colonoscopy. However, genetic and epigenetic cha...
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Sakiko Hiraoka,
Jun Kato,
Masashi Tatsukawa,
Keita Harada,
Hideyuki Fujita,
Tamiya Morikawa,
Hidenori Shiraha,
Yasushi Shiratori
et al.
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Full-length article
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pages 379-389
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Limited Value of Alarm Features in the Diagnosis of Upper Gastrointestinal Malignancy: Systematic Review and Meta-analysis
Background & Aims: Alarm features such as dysphagia, weight loss, or anemia raise concern of an upper gastrointestinal malignancy in patients with dyspepsia. The aim of this study was to determine...
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Nimish Vakil,
Paul Moayyedi,
M. Brian Fennerty,
Nicholas J. Talley
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Full-length article
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pages 390-401
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Allergy Controls the Population Density of Necator americanus in the Small Intestine
Background & Aims: Nearly 700 million people remain infected with hookworms. Although allergy is intuitively linked to immunity against helminths, few positive examples have been characterized. La...
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John Croese,
Marnie J. Wood,
Wayne Melrose,
Richard Speare
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Full-length article
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pages 402-409
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The Effect of Acute Psychologic Stress on Systemic and Rectal Mucosal Measures of Inflammation in Ulcerative Colitis
Background & Aims: Recent studies suggest that life events and chronic stress increase the risk of relapse in inflammatory bowel disease. Our aim was to study the effects of acute psychologic stre...
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Joel E. Mawdsley,
Marion G. Macey,
Roger M. Feakins,
Louise Langmead,
David S. Rampton
et al.
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Full-length article
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pages 410-419
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Adenosine Diphosphate Ribosyl Transferase and X-Ray Repair Cross-Complementing 1 Polymorphisms in Gastric Cardia Cancer
Background & Aims: Adenosine diphosphate ribosyl transferase (ADPRT) and x-ray repair cross-complementing 1 (XRCC1) are major DNA base excision repair proteins acting interactively in repair proce...
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Xiaoping Miao,
Xuemei Zhang,
Lingqiang Zhang,
Yongli Guo,
Bingtao Hao,
Wen Tan,
Fuchu He,
Dongxin Lin
et al.
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Full-length article
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pages 420-427
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A Unique Dendritic Cell Subset Accumulates in the Celiac Lesion and Efficiently Activates Gluten-Reactive T Cells
Background & Aims: Celiac disease is a chronic inflammation of the duodenal mucosa driven by gluten-reactive T cells restricted by the disease-associated HLA-DQ2 molecule. The mechanisms that regu...
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Melinda Ráki,
Stig Tollefsen,
Øyvind Molberg,
Knut E.A. Lundin,
Ludvig M. Sollid,
Frode L. Jahnsen
et al.
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Full-length article
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pages 428-438
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Immunohistochemical Expression of MYH Protein Can Be Used to Identify Patients With MYH-Associated Polyposis
Background & Aims: MYH-associated polyposis is a recently described, autosomal-recessive disease characterized by multiple colorectal adenomas and cancer. There are only few immunohistochemical st...
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Carmela Di Gregorio,
Milo Frattini,
Stefania Maffei,
Giovanni Ponti,
Lorena Losi,
Monica Pedroni,
Tiziana Venesio,
Lucio Bertario,
Liliana Varesco,
Mauro Risio,
Maurizio Ponz de Leon
et al.
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Full-length article
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pages 439-444
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Incidence and Epidemiology of Irritable Bowel Syndrome After a Large Waterborne Outbreak of Bacterial Dysentery
Background & Aims: Postinfectious irritable bowel syndrome (PI-IBS) is a common clinical phenomenon. To better define its incidence and epidemiology, a large cohort study was initiated after the c...
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John K. Marshall,
Marroon Thabane,
Amit X. Garg,
William F. Clark,
Marina Salvadori,
Stephen M. Collins,
Walkerton Health Study Investigators
et al.
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Full-length article
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pages 445-450
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| Clinical - Liver, Pancreas, and Biliary Tract |
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Peginterferon-Alfa2a Plus Ribavirin for 48 Versus 72 Weeks in Patients With Detectable Hepatitis C Virus RNA at Week 4 of Treatment
Background & Aims: Patients with chronic hepatitis C who do not respond rapidly to therapy have a low chance of developing a sustained virologic response (SVR) when treated for 48 weeks. This stud...
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José M. Sánchez–Tapias,
Moisés Diago,
Pedro Escartín,
Jaime Enríquez,
Manuel Romero–Gómez,
Rafael Bárcena,
Javier Crespo,
Raúl Andrade,
Eva Martínez–Bauer,
Ramón Pérez,
Milagros Testillano,
Ramón Planas,
Ricard Solá,
Manuel García–Bengoechea,
Javier Garcia–Samaniego,
Miguel Muñoz–Sánchez,
Ricardo Moreno–Otero,
TeraViC-4 Study Group
et al.
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Full-length article
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pages 451-460
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Prospective Cohort Study of Transarterial Chemoembolization for Unresectable Hepatocellular Carcinoma in 8510 Patients
Background & Aims: To elucidate the survival of the patients with unresectable hepatocellular carcinoma (HCC) who underwent transcatheter arterial lipiodol chemoembolization (TACE) and to analyze ...
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Kenichi Takayasu,
Shigeki Arii,
Iwao Ikai,
Masao Omata,
Kiwamu Okita,
Takafumi Ichida,
Yutaka Matsuyama,
Yasuni Nakanuma,
Masamichi Kojiro,
Masatoshi Makuuchi,
Yoshio Yamaoka,
Liver Cancer Study Group of Japan
et al.
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Full-length article
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pages 461-469
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Peginterferon and Ribavirin Treatment in African American and Caucasian American Patients With Hepatitis C Genotype 1
Background & Aims: Compared with Caucasian Americans (CA), African Americans (AA) with chronic hepatitis C are less likely to respond to interferon-based antiviral therapy. Methods: In a multicent...
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Hari S. Conjeevaram,
Michael W. Fried,
Lennox J. Jeffers,
Norah A. Terrault,
Thelma E. Wiley–Lucas,
Nezam Afdhal,
Robert S. Brown,
Steven H. Belle,
Jay H. Hoofnagle,
David E. Kleiner,
Charles D. Howell,
Virahep-C Study Group
et al.
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Full-length article
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pages 470-477
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Hepatitis C Virus Genotypes and Viral Concentrations in Participants of a General Population Survey in the United States
Background & Aims: Estimates of the long-term benefits of antiviral therapies for chronic hepatitis C are influenced by the frequency of characteristics that affect response in the population trea...
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Omana V. Nainan,
Miriam J. Alter,
Deanna Kruszon-Moran,
Feng-Xiang Gao,
Guoliang Xia,
Geraldine McQuillan,
Harold S. Margolis
et al.
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Full-length article
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pages 478-484
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| Basic - Alimentary Tract |
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CD8+ Cytotoxic T Cells Induce Relapsing Colitis in Normal Mice
Background & Aims: Most mouse models of IBD have emphasized an effector role of type-1 CD4+ T cells in colitis. The aim of this study was to develop a model of antigen-specific relapsing colitis t...
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Stéphane Nancey,
Sébastien Holvöet,
Ivan Graber,
Grégoire Joubert,
David Philippe,
Stefan Martin,
Jean–François Nicolas,
Pierre Desreumaux,
Bernard Flourié,
Dominique Kaiserlian
et al.
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Full-length article
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pages 485-496
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The Role of Tumor Necrosis Factor α in Down-Regulation of Osteoblast Phex Gene Expression in Experimental Murine Colitis
Background & Aims: Reduced bone mass is a common complication of inflammatory bowel disease (IBD), although the mechanisms that contribute to osteopenia are not completely understood. Tumor necros...
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Jennifer K. Uno,
Olga I. Kolek,
Eric R. Hines,
Hua Xu,
Barbara N. Timmermann,
Pawel R. Kiela,
Fayez K. Ghishan
et al.
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Full-length article
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pages 497-509
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Autoimmune-Mediated Intestinal Inflammation–Impact and Regulation of Antigen-Specific CD8+ T Cells
Background & Aims: Few data exist regarding mechanisms of mucosal CD8+ T-cell reactivity to epithelial-specific antigen. To dissect the immunologic mechanisms underlying CD8+ T-cell dysregulation,...
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Astrid Maria Westendorf,
Diana Fleissner,
Stefanie Deppenmeier,
Achim Dieter Gruber,
Dunja Bruder,
Wiebke Hansen,
Roland Liblau,
Jan Buer
et al.
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Full-length article
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pages 510-524
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CD25+/Foxp3+ T Cells Regulate Gastric Inflammation and Helicobacter pylori Colonization In Vivo
Background & Aims:Helicobacter pylori infects more than half of the world’s population. In contrast to most other pathogens, the microbe persists for the virtual life of its host. It is unclear wh...
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Roland Rad,
Lena Brenner,
Stefan Bauer,
Susanne Schwendy,
Laura Layland,
Clarissa Prazeres da Costa,
Wolfgang Reindl,
Anar Dossumbekova,
Mathias Friedrich,
Dieter Saur,
Hermann Wagner,
Roland M. Schmid,
Christian Prinz
et al.
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Full-length article
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pages 525-537
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PPARβ/δ Regulates Paneth Cell Differentiation Via Controlling the Hedgehog Signaling Pathway
Background & Aims: All 4 differentiated epithelial cell types found in the intestinal epithelium derive from the intestinal epithelial stem cells present in the crypt unit, in a process whose mole...
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Frédéric Varnat,
Béatrice Bordier–Ten Heggeler,
Philippe Grisel,
Nathalie Boucard,
Irène Corthésy–Theulaz,
Walter Wahli,
Béatrice Desvergne
et al.
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Full-length article
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pages 538-553
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c-Fos Is a Critical Mediator of Inflammatory-Mediated Repression of the Apical Sodium-Dependent Bile Acid Transporter
Background & Aims: Ileal bile acid malabsorption is present in Crohn’s ileitis. The molecular mechanisms of regulation of the apical sodium-dependent bile acid transporter (ASBT) by inflammatory c...
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Ezequiel Neimark,
Frank Chen,
Xiaoping Li,
Margret S. Magid,
Teresa M. Alasio,
Tamara Frankenberg,
Jyoti Sinha,
Paul A. Dawson,
Benjamin L. Shneider
et al.
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Full-length article
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pages 554-567
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Contribution of 5-HT2A Receptor in Nematode Infection-Induced Murine Intestinal Smooth Muscle Hypercontractility
Background & Aims: Enteric nematode infection induces a smooth muscle hypercontractility that depends on interleukin (IL)-4 and IL-13 activation of the signal transducer and activator of transcrip...
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Aiping Zhao,
Joseph F. Urban,
Motoko Morimoto,
Justin E. Elfrey,
Kathleen B. Madden,
Fred D. Finkelman,
Terez Shea–Donohue
et al.
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Full-length article
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pages 568-578
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Deletion of Mtgr1 Sensitizes the Colonic Epithelium to Dextran Sodium Sulfate–Induced Colitis
Background & Aims: The disruption of homeostasis between proliferation and apoptosis in the colonic epithelium contributes to the pathogenesis of human ulcerative colitis. Mice lacking the transcr...
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J. Andres Martinez,
Christopher S. Williams,
Joseph M. Amann,
Tiffany C. Ellis,
Isabel Moreno–Miralles,
M. Kay Washington,
Paul Gregoli,
Scott W. Hiebert
et al.
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Full-length article
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pages 579-588
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The Essential Role of Insulin-Like Growth Factor-1 in the Intestinal Tropic Effects of Glucagon-Like Peptide-2 in Mice
Background & Aims: Glucagon-like peptide-2 (GLP-2) is an intestinal hormone that acts through unknown pathways to induce intestinal growth. We investigated the role of the insulin-like growth fact...
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Philip E. Dubé,
Catherine L. Forse,
Jasmine Bahrami,
Patricia L. Brubaker
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Full-length article
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pages 589-605
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| Basic - Liver, Pancreas, and Biliary Tract |
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Autoreactive T-Cell Responses in Primary Biliary Cirrhosis Are Proinflammatory Whereas Those of Controls Are Regulatory
Background & Aims: Autoreactive T cells that proliferate in response to autoantigens are found in both autoimmune disease and controls but have important qualitative differences in relative activa...
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Shinji Shimoda,
Fumihiko Ishikawa,
Takashi Kamihira,
Atsumasa Komori,
Hiroaki Niiro,
Eishi Baba,
Kenichi Harada,
Kumiko Isse,
Yasuni Nakanuma,
Hiromi Ishibashi,
M. Eric Gershwin,
Mine Harada
et al.
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Full-length article
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pages 606-618
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| Clinical Management |
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Author(s) |
Type |
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Asymptomatic Liver Mass
A 52-year-old man with no prior medical problems is referred after a virtual colonoscopy done for colon cancer screening revealed a 3-cm solid liver mass. The patient has no prior history of liver dis...
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Robert S. Brown
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Full-length article
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pages 619-623
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| Case Report |
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Combined Mutations of Canalicular Transporter Proteins Cause Severe Intrahepatic Cholestasis of Pregnancy
Intrahepatic cholestasis of pregnancy (ICP) is a cholestatic disorder that usually develops in the third trimester of pregnancy and persists until delivery. The cause of ICP remains elusive, but there...
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Verena Keitel,
Christoph Vogt,
Dieter Häussinger,
Ralf Kubitz
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Full-length article
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pages 624-629
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| Microarrays and Other New Technologies |
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CD24 Is a New Oncogene, Early at the Multistep Process of Colorectal Cancer Carcinogenesis
Background & Aims: The aim of this study was to identify genes that play a role in colorectal cancer (CRC) carcinogenesis by analysis of differential gene expression of normal and transformed CRC ...
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Eyal Sagiv,
Lorenzo Memeo,
Adi Karin,
Diana Kazanov,
Jasmin Jacob–Hirsch,
Mahesh Mansukhani,
Gidi Rechavi,
Hanina Hibshoosh,
Nadir Arber
et al.
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Full-length article
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pages 630-639
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| Special Reports and Reviews |
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Integrated Upper Gastrointestinal Response to Food Intake
26 March 2006
Ingestion of food simultaneously activates gastrointestinal motility, gastric and pancreatic secretion, and release of gastrointestinal hormones that, in turn, modulate motor, secretory, and absorptiv...
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Michael Camilleri
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Review article
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pages 640-658
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| CME Activities |
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Author(s) |
Type |
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Continuing Medical Education Exam 1: August 2006
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Michael B. Wallace
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Examination
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pages 659-660
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Continuing Medical Education Exam 2: August 2006
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Michael B. Wallace
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Examination
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page 660
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| Editorials |
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Type |
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Visceral Hypersensitivity: Fact or Fiction
The predominant reason why functional gastrointestinal disorder (FGID) patients seek medical attention is chronic, episodic pain. Heightened perception of experimental visceral stimuli (visceral hyper...
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Qasim Aziz
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Editorial
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pages 661-664
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Serologies in Crohn’s Disease: Can We Change the Gray Zone to Black and White?
The goal of patients with inflammatory bowel disease and the physicians treating them should be to restore normal health. To that end, therapy for Crohn’s disease and ulcerative colitis continues to i...
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María T. Abreu
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Editorial
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pages 664-667
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In IBD Eight Can Come Before Four
In addition to its function as a central part of the digestive system, the intestinal epithelium also forms a physical barrier between the antigen-rich gut lumen and the sterile core of the body. The ...
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Hilde Cheroutre
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Editorial
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pages 667-670
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| Selected Summaries |
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Budd-Chiari Syndrome: A clinical model of the hepatorenal reflex?
Hernandez-Guerra M, Lopez E, Beliot P, Piera C, Turnes J, Abraldes JG, Bosch J, Garcia-Pagan JC (Hepatic hemodynamic Laboratory, and Department of Nuclear Medicine, Hospital Clinic, Barcelona, Spain)....
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Laurie Blendis
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Discussion
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pages 671-672
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Ecological diversity measures predict cancer progression in Barrett’s esophagus
Maley CC, Galipeau PC, Finley JC, Wongsurawat VJ, Li X, Sanchez CA, Paulson TG, Blount PL, Risques RA, Rabinovitch PS, Reid BJ. (The Wistar Institute, Philadelphia, Pennsylvania; Divisions of Human Bi...
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Hiroshi Nakagawa
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Discussion
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pages 672-673
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Reply
We are grateful to Dr Nakagawa for highlighting our work and summarizing so well the complexities of the genetics of Barrett’s neoplastic progression. We agree with his conclusions and would like to r...
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Carlo C. Maley
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Discussion
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pages 673-674
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Multicenter timolol study: The value of timolol and hemodynamic monitoring in the management of portal hypertensive cirrhotics with no esophageal varices
Groszmann RJ, Garc-a-Tsao G, Bosch H, Grace ND, Burroughs AK, Planas R, Escorsell A, Garcia-Pagan JC, Patch D, Matloff DS, Gao H, Makuch R for the Portal Hypertension Collaborative Group (Yale Univers...
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Raj Vuppalanchi,
Naga Chalasani
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Discussion
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pages 674-676
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Reply
We appreciate the opportunity to clarify a number of issues that were left out of our article because of space limitations.
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Roberto J. Groszmann,
Guadalupe Garcia-Tsao
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Discussion
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page 676
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Drinker’s pancreas and abnormal diffusion-weighted MR: What’s the connection?
Erturk SM, Ichikawa T, Motosugi U, Hironobu S, Tsutomu A (Department of Radiology, Sisli Etfal Hosptial, Istanbul, Turkey). Diffusion-weighted MR imaging in the evaluation of pancreatic exocrine funct...
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Suresh T. Chari,
Naoki Takahashi
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Discussion
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pages 676-678
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Snack time
Milne AC, Avenell A, Potter J (University of Aberdeen, Aberdeen, Scotland, UK; Wollongong Hospital, Sydney, Australia). Meta-analysis: protein and energy supplementation in older people. Ann Intern Me...
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Ronald L. Koretz
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Discussion
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pages 678-679
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| Print and Media Reviews |
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Book review
Ambitious yet accessible, The Placebo Effect and Health is a provocative treatise posing fundamental questions about worldwide healthcare using the prism of the placebo effect. In this well-written, e...
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Evan S. Dellon
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Book review
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pages 680-681
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Book review
Gastroenterology and Hepatology Board Review is the second edition of a textbook designed to prepare readers for the Board Examination. This book is one in a series of Pearls of Wisdom texts published...
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Jeffrey T. Wei
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Book review
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page 681
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| Correspondence |
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Author(s) |
Type |
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Treatment of Acute Hepatitis C—How to Explain the Differences?
We would like to comment on the article by Kamal et al on the treatment of acute hepatitis C published in the March 2006 issue. The study provides information on the optimal timing of PEG-interferon a...
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Heiner Wedemeyer,
Markus Cornberg,
Johannes Wiegand,
Elmar Jäckel,
Michael P. Manns
et al.
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Correspondence
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pages 682-683
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Peginterferon alfa-2b Therapy in Acute Hepatitis C: Impact of Onset of Therapy on Sustained Virologic Response
We were interested to read the report of peginterferon alfa-2b therapy in acute hepatitis C by Kamal et al and wish to propose a moratorium on further studies of the treatment of acute HCV hepatitis. ...
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Stephen D.H. Malnick,
Alon Basevitch
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Correspondence
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page 683
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Reply
We would like to thank Malnick et al and Wedemeyer et al for their correspondence regarding our recent manuscript, the goal of which was to determine the optimal time to initiate treatment in acute he...
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Sanaa M. Kamal
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Correspondence
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pages 683-684
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The Risk of Colorectal Cancer in Ulcerative Colitis in a Population-Based Setting
It is refreshing to see the current community based data of Jess et al mirror that which has been reported in 2001, from the community of Orlando, Florida. The findings of this paper may be somewhat s...
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Douglas Sprung
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Correspondence
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page 684
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Reply
We thank Dr. Sprung for his interest in our recent paper describing a surprisingly low risk of colorectal cancer in a population-based cohort of inflammatory bowel disease from a small but well-define...
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Tine Jess,
Edward V. Loftus
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Correspondence
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pages 684-685
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Hepatitis C Infection and Lymphomas: Is There any Benefit in Viral Treatment?
Pal et al reported that the hepatitis C virus (HCV) has the capacity to infect and replicate in vitro and in peripheral lymph nodes. Their work adds to the evidence that HCV has lymphoproliferative ac...
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Laia Bruni,
Silvia De Sanjose
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Correspondence
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pages 685-686
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Reply
I write in response to the Letter to the Editor by Bruni et al regarding our recent description of HCV replication in perihepatic lymph nodes in vivo. Regarding the main point of the letter: the autho...
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David Gretch
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Correspondence
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pages 686-687
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