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Cover 1 page OFC Preview | Full-Text PDF (232 KB)
This Month in Gastroenterology
This Month in Gastroenterology, 01 June 2009 Jan Tack, John M. Carethers pages 1-3 Preview | Full Text | Full-Text PDF (609 KB)
Gastroenterology and Hepatology News
The Institute of Medicine Calls for Voluntary and Regulatory Measures to Reduce Conflicts of Interest, 18 May 2009 Les Lang page 4 Preview | Full Text | Full-Text PDF (143 KB)
Genome-Wide Association Study Points to Colorectal Cancer Culprit, 18 May 2009 Les Lang pages 4-5 Preview | Full Text | Full-Text PDF (192 KB)
Transplanted Hepatocytes Function in Older Animals But Do Not Proliferate as Much as in Younger Ones, 18 May 2009 Les Lang page 5 Preview | Full Text | Full-Text PDF (118 KB)
Jeremy Robin Jass, GI Pathologist, 18 May 2009 Les Lang pages 5-6 Preview | Full Text | Full-Text PDF (129 KB)
Mini-Reviews and Perspectives
Computed Tomographic Colonography: Current Perspectives and Future Directions, 18 May 2009 Don C. Rockey pages 7-14 Abstract | Full Text | Full-Text PDF (670 KB)
OLFM4 Is a Robust Marker for Stem Cells in Human Intestine and Marks a Subset of Colorectal Cancer Cells, 18 May 2009 Laurens G. van der Flier, Andrea Haegebarth, Daniel E. Stange, Marc van de Wetering, Hans Clevers pages 15-17 Preview | Full Text | Full-Text PDF (1231 KB)
Comment From the Editor
Intestinal Lipids as Signaling Molecules, 01 June 2009 Rexford S. Ahima pages 18-19 Preview | Full Text | Full-Text PDF (467 KB)
Editorials
Evidence That Proton-Pump Inhibitor Therapy Induces the Symptoms it Is Used to Treat, 01 June 2009 Kenneth E.L. McColl, Derek Gillen pages 20-22 Preview | Full Text | Full-Text PDF (487 KB)
New Epidemiologic Evidence on Functional Dyspepsia Subgroups and Their Relationship to Psychosocial Dysfunction, 01 June 2009 Lukas Van Oudenhove, Jan Tack pages 23-26 Preview | Full Text | Full-Text PDF (352 KB)
α-Fetoprotein for Hepatocellular Carcinoma Diagnosis: The Demise of a Brilliant Star, 01 June 2009 Alejandro Forner, María Reig, Jordi Bruix pages 26-29 Preview | Full Text | Full-Text PDF (257 KB)
Paneth Cell Development, Differentiation, and Function: New Molecular Cues, 04 June 2009 Thaddeus S. Stappenbeck pages 30-33 Preview | Full Text | Full-Text PDF (475 KB)
Intersection of Transforming Growth Factor-β and Wnt Signaling Pathways in Colorectal Cancer and Metastasis, 01 June 2009 John M. Carethers pages 33-36 Preview | Full Text | Full-Text PDF (698 KB)
Fucose Is on the TRAIL of Colon Cancer, 01 June 2009 Robert S. Haltiwanger pages 36-39 Preview | Full Text | Full-Text PDF (473 KB)
Clinical Challenges and Images in GI
A Rare Cause of Obstructive Jaundice, 08 June 2009 Ahmed Abdel Samie, Rui Sun, Lorenz Theilmann page 40 Preview | Full Text | Full-Text PDF (423 KB)
A Metamorphic Lesion, 03 June 2009 Carla Rolanda, Raquel Gonçalves, Guilherme Macedo page 41 Preview | Full Text | Full-Text PDF (798 KB)
Unremitting Upper GI Bleeding from a Duodenal Mass, 01 June 2009 Koushik K. Das, Vasudha Dhar page 42 Preview | Full Text | Full-Text PDF (1253 KB)
Electronic Clinical Challenges and Images in GI
A Case With Duodenal Bleeding, 01 June 2009 Jen-Wei Chou, Wen-Hsin Huang, Hsueh-Chou Lai pages e1-e2 Preview | Full Text | Full-Text PDF (638 KB)
A “Crescent-in-doughnut” Lesion at Right Lower Quadrant Abdomen, 01 June 2009 Chen–Shuan Chung, Ming–Yang Wang, Hsiu–Po Wang pages e3-e4 Preview | Full Text | Full-Text PDF (956 KB)
Working Out the Bug in the Accordion, 05 June 2009 Natasha Chandok, Patrick S. Kamath pages e5-e6 Preview | Full Text | Full-Text PDF (309 KB)
Imaging and Advanced Technology
Contrast-Enhanced Ultrasonographic Evaluation of Inflammatory Activity in Crohn's Disease, 06 May 2009 Vincenzo Migaleddu, Antonio M. Scanu, Emilio Quaia, Paolo Cossu Rocca, Maria Pina Dore, Domenico Scanu, Lorenza Azzali, Giuseppe Virgilio pages 43-52 Abstract | Full Text | Full-Text PDF (1023 KB) | Bonus Content
Bioengineered Internal Anal Sphincter Derived From Isolated Human Internal Anal Sphincter Smooth Muscle Cells, 31 March 2009 Sita Somara, Robert R. Gilmont, Robert G. Dennis, Khalil N. Bitar pages 53-61 Abstract | Full Text | Full-Text PDF (1534 KB)
Reviews in Basic and Clinical Gastroenterology
Mechanisms of Liver Development: Concepts for Understanding Liver Disorders and Design of Novel Therapies, 31 March 2009 Frédéric P. Lemaigre pages 62-79 Abstract | Full Text | Full-Text PDF (1691 KB)
Clinical-Alimentary Tract
Proton-Pump Inhibitor Therapy Induces Acid-Related Symptoms in Healthy Volunteers After Withdrawal of Therapy, 13 April 2009 Christina Reimer, Bo Søndergaard, Linda Hilsted, Peter Bytzer pages 80-87.e1 Abstract | Full Text | Full-Text PDF (414 KB)
Increased Prevalence and Mortality in Undiagnosed Celiac Disease, 13 April 2009 Alberto Rubio–Tapia, Robert A. Kyle, Edward L. Kaplan, Dwight R. Johnson, William Page, Frederick Erdtmann, Tricia L. Brantner, W. Ray Kim, Tara K. Phelps, Brian D. Lahr, Alan R. Zinsmeister, L. Joseph Melton, Joseph A. Murray pages 88-93 Abstract | Full Text | Full-Text PDF (271 KB)
Anxiety Is Associated With Uninvestigated and Functional Dyspepsia (Rome III Criteria) in a Swedish Population-Based Study, 31 March 2009 Pertti Aro, Nicholas J. Talley, Jukka Ronkainen, Tom Storskrubb, Michael Vieth, Sven–Erik Johansson, Elisabeth Bolling–Sternevald, Lars Agréus pages 94-100 Abstract | Full Text | Full-Text PDF (289 KB)
Frequency of Mitochondrial Defects in Patients With Chronic Intestinal Pseudo-Obstruction, 03 April 2009 Aurélien Amiot, Maya Tchikviladzé, Francisca Joly, Abdelhamid Slama, Dominique Cazals Hatem, Claude Jardel, Bernard Messing, Anne Lombès pages 101-109 Abstract | Full Text | Full-Text PDF (1406 KB)
Clinical Advances in Liver, Pancreas, and Biliary Tract
α-Fetoprotein, Des-γ Carboxyprothrombin, and Lectin-Bound α-Fetoprotein in Early Hepatocellular Carcinoma, 10 April 2009 Jorge A. Marrero, Ziding Feng, Yinghui Wang, Mindie H. Nguyen, Alex S. Befeler, Lewis R. Roberts, K. Rajender Reddy, Denise Harnois, Josep M. Llovet, Daniel Normolle, Jackie Dalhgren, David Chia, Anna S. Lok, Paul D. Wagner, Sudhir Srivastava, Myron Schwartz pages 110-118 Abstract | Full Text | Full-Text PDF (778 KB)
Clinical-Liver, Pancreas, and Biliary Tract
Acute Hemodynamic Response to β-Blockers and Prediction of Long-term Outcome in Primary Prophylaxis of Variceal Bleeding, 03 April 2009 Càndid Villanueva, Carles Aracil, Alan Colomo, Virginia Hernández–Gea, Josep M. López–Balaguer, Cristina Alvarez–Urturi, Xavier Torras, Joaquim Balanzó, Carlos Guarner pages 119-128 Abstract | Full Text | Full-Text PDF (833 KB)
Early Changes in Blood Urea Nitrogen Predict Mortality in Acute Pancreatitis, 03 April 2009 Bechien U. Wu, Richard S. Johannes, Xiaowu Sun, Darwin L. Conwell, Peter A. Banks pages 129-135 Abstract | Full Text | Full-Text PDF (637 KB)
Basic-Alimentary Tract
Colony Stimulating Factor-1 Dependence of Paneth Cell Development in the Mouse Small Intestine, 19 March 2009 Duy Huynh, Xu–Ming Dai, Sayan Nandi, Sally Lightowler, Melanie Trivett, Chee–Kai Chan, Ivan Bertoncello, Robert G. Ramsay, E. Richard Stanley pages 136-144.e3 Abstract | Full Text | Full-Text PDF (3865 KB)
Notch Signaling Promotes the Generation of EphrinB1-Positive Intestinal Epithelial Cells, 31 March 2009 Bon–Kyoung Koo, Hyoung–Soo Lim, Hee Jin Chang, Mi–Jeong Yoon, Yongwook Choi, Myung–Phil Kong, Cheol–Hee Kim, Jin–Man Kim, Jae–Gahb Park, Young–Yun Kong pages 145-155.e3 Abstract | Full Text | Full-Text PDF (2942 KB)
The Symplekin/ZONAB Complex Inhibits Intestinal Cell Differentiation by the Repression of AML1/Runx1, 31 March 2009 Michael Buchert, Charbel Darido, Ebba Lagerqvist, Anna Sedello, Chantal Cazevieille, Frank Buchholz, Jean–Francois Bourgaux, Julie Pannequin, Dominique Joubert, Frédéric Hollande pages 156-164.e3 Abstract | Full Text | Full-Text PDF (1657 KB)
A Colorectal Cancer Expression Profile That Includes Transforming Growth Factor β Inhibitor BAMBI Predicts Metastatic Potential, 31 March 2009 Johannes Fritzmann, Markus Morkel, Daniel Besser, Jan Budczies, Frauke Kosel, Felix H. Brembeck, Ulrike Stein, Iduna Fichtner, Peter M. Schlag, Walter Birchmeier pages 165-175 Abstract | Full Text | Full-Text PDF (2120 KB) | Bonus Content
Frequent Inactivation of Axon Guidance Molecule RGMA in Human Colon Cancer Through Genetic and Epigenetic Mechanisms, 19 March 2009 Vivian S.W. Li, Siu Tsan Yuen, Tsun Leung Chan, Helen H.N. Yan, Wai Lun Law, Bonnie H.Y. Yeung, Annie S.Y. Chan, Wai Yin Tsui, Samuel So, Xin Chen, Suet Yi Leung pages 176-187 Abstract | Full Text | Full-Text PDF (3239 KB) | Bonus Content
Deficiency of GMDS Leads to Escape from NK Cell-Mediated Tumor Surveillance Through Modulation of TRAIL Signaling, 09 April 2009 Kenta Moriwaki, Katsuhisa Noda, Yoichi Furukawa, Kenji Ohshima, Airi Uchiyama, Tsutomu Nakagawa, Naoyuki Taniguchi, Yataro Daigo, Yusuke Nakamura, Norio Hayashi, Eiji Miyoshi pages 188-198.e2 Abstract | Full Text | Full-Text PDF (2209 KB)
Prohibitin Is a Novel Regulator of Antioxidant Response That Attenuates Colonic Inflammation in Mice, 26 March 2009 Arianne L. Theiss, Matam Vijay–Kumar, Tracy S. Obertone, Dean P. Jones, Jason M. Hansen, Andrew T. Gewirtz, Didier Merlin, Shanthi V. Sitaraman pages 199-208.e6 Abstract | Full Text | Full-Text PDF (2174 KB)
Colitis-Associated Variant of TLR2 Causes Impaired Mucosal Repair Because of TFF3 Deficiency, 19 March 2009 Daniel K. Podolsky, Guido Gerken, Annette Eyking, Elke Cario pages 209-220 Abstract | Full Text | Full-Text PDF (2919 KB) | Bonus Content
Heparin-Binding EGF-Like Growth Factor Increases Intestinal Microvascular Blood Flow in Necrotizing Enterocolitis, 09 April 2009 Xiaoyi Yu, Andrei Radulescu, Nicholas Zorko, Gail E. Besner pages 221-230 Abstract | Full Text | Full-Text PDF (7173 KB) | Bonus Content
Delineation of the Chemomechanosensory Regulation of Gastrin Secretion Using Pure Rodent G Cells, 16 January 2009 Mark Kidd, Øyvind Hauso, Ignat Drozdov, Bjorn I. Gustafsson, Irvin M. Modlin pages 231-241.e10 Abstract | Full Text | Full-Text PDF (4518 KB)
Laminin γ2 Mediates Wnt5a-Induced Invasion of Gastric Cancer Cells, 11 February 2009 Hideki Yamamoto, Yasuhiko Kitadai, Hideki Yamamoto, Naohide Oue, Hideki Ohdan, Wataru Yasui, Akira Kikuchi pages 242-252.e6 Abstract | Full Text | Full-Text PDF (3337 KB)
Negative Mood Affects Brain Processing of Visceral Sensation, 23 February 2009 Steven J. Coen, Lidia Yágüez, Qasim Aziz, Martina T. Mitterschiffthaler, Mick Brammer, Steven C.R. Williams, Lloyd J. Gregory pages 253-261.e2 Abstract | Full Text | Full-Text PDF (694 KB)
Mechanisms of Neural Response to Gastrointestinal Nutritive Stimuli: The Gut-Brain Axis, 26 February 2009 Tomokazu Tsurugizawa, Akira Uematsu, Eiji Nakamura, Mai Hasumura, Mariko Hirota, Takashi Kondoh, Hisayuki Uneyama, Kunio Torii pages 262-273 Abstract | Full Text | Full-Text PDF (1835 KB)
Identification of Medium/High-Threshold Extrinsic Mechanosensitive Afferent Nerves to the Gastrointestinal Tract, 06 March 2009 Xingyun Song, Bao Nan Chen, Vladimir P. Zagorodnyuk, Penny A. Lynn, L. Ashley Blackshaw, David Grundy, Alan M. Brunsden, Marcello Costa, Simon J.H. Brookes pages 274-284.e1 Abstract | Full Text | Full-Text PDF (2922 KB)
Basic-Liver, Pancreas, and Biliary Tract
Hepatitis C Virus and Disrupted Interferon Signaling Promote Lymphoproliferation via Type II CD95 and Interleukins, 10 April 2009 Keigo Machida, Kyoko Tsukiyama–Kohara, Satoshi Sekiguch, Eiji Seike, Shigenobu Tóne, Yukiko Hayashi, Yoshimi Tobita, Yuri Kasama, Masumi Shimizu, Hidemi Takahashi, Chyoji Taya, Hiromichi Yonekawa, Nobuyuki Tanaka, Michinori Kohara pages 285-296.e11 Abstract | Full Text | Full-Text PDF (4888 KB)
c-Met Confers Protection Against Chronic Liver Tissue Damage and Fibrosis Progression After Bile Duct Ligation in Mice, 06 February 2009 Arne Giebeler, Mark V. Boekschoten, Christian Klein, Malgorzata Borowiak, Carmen Birchmeier, Nikolaus Gassler, Hermann E. Wasmuth, Michael Müller, Christian Trautwein, Konrad L. Streetz pages 297-308.e4 Abstract | Full Text | Full-Text PDF (3443 KB) | Bonus Content
Antifibrotic Effects of CXCL9 and Its Receptor CXCR3 in Livers of Mice and Humans, 03 April 2009 Hermann E. Wasmuth, Frank Lammert, Mirko Moreno Zaldivar, Ralf Weiskirchen, Claus Hellerbrand, David Scholten, Marie-Luise Berres, Henning Zimmermann, Konrad L. Streetz, Frank Tacke, Sonja Hillebrandt, Petra Schmitz, Hildegard Keppeler, Thomas Berg, Edgar Dahl, Nikolaus Gassler, Scott L. Friedman, Christian Trautwein pages 309-319.e3 Abstract | Full Text | Full-Text PDF (2289 KB)
Gut Homing Receptors on CD8 T Cells Are Retinoic Acid Dependent and Not Maintained by Liver Dendritic or Stellate Cells, 23 February 2009 Bertus Eksteen, J. Rodrigo Mora, Emma L. Haughton, Neil C. Henderson, Laura Lee–Turner, Eduardo J. Villablanca, Stuart M. Curbishley, Alex I. Aspinall, Ulrich H. von Andrian, David H. Adams pages 320-329 Abstract | Full Text | Full-Text PDF (1875 KB) | Bonus Content
Y-Box Binding Protein-1 Down-Regulates Expression of Carbamoyl Phosphate Synthetase-I by Suppressing CCAAT Enhancer-Binding Protein-Alpha Function in Mice, 09 March 2009 Yen–Rong Chen, Keisuke Sekine, Koji Nakamura, Hiroyuki Yanai, Minoru Tanaka, Atsushi Miyajima pages 330-340 Abstract | Full Text | Full-Text PDF (1808 KB) | Bonus Content
Cannabinoid Type 1 Receptor Antagonism Delays Ascites Formation in Rats With Cirrhosis, 16 January 2009 Marco Domenicali, Paolo Caraceni, Ferdinando Giannone, Anna Maria Pertosa, Alessandro Principe, Andrea Zambruni, Franco Trevisani, Tiziano Croci, Mauro Bernardi pages 341-349 Abstract | Full Text | Full-Text PDF (1738 KB)
Impaired Autolysosome Formation Correlates With Lamp-2 Depletion: Role of Apoptosis, Autophagy, and Necrosis in Pancreatitis, 10 April 2009 Franco Fortunato, Heinrich Bürgers, Frank Bergmann, Peter Rieger, Markus W. Büchler, Guido Kroemer, Jens Werner pages 350-360.e5 Abstract | Full Text | Full-Text PDF (4000 KB)
E-Cadherin Regulates Metastasis of Pancreatic Cancer In Vivo and Is Suppressed by a SNAIL/HDAC1/HDAC2 Repressor Complex, 10 April 2009 Johannes von Burstin, Stefan Eser, Mariel C. Paul, Barbara Seidler, Martina Brandl, Marlena Messer, Alexander von Werder, Annegret Schmidt, Jörg Mages, Philipp Pagel, Angelika Schnieke, Roland M. Schmid, Günter Schneider, Dieter Saur pages 361-371.e5 Abstract | Full Text | Full-Text PDF (3229 KB)
Continuing Medical Education (CME) Activities
Continuing Medical Education Exam 1, July 2009, 01 June 2009 Michael B. Wallace pages 372-373 Preview | Full-Text PDF (94 KB)
Continuing Medical Education Exam 2, July 2009, 01 June 2009 pages 373-374 Preview | Full-Text PDF (89 KB)
Selected Summaries
To Expand or Not to Expand the Criteria for Hepatocellular Carcinoma Transplantation: Is Downstaging the Answer?, 01 June 2009 Alejandro Forner, Jordi Bruix pages 375-376 Preview | Full Text | Full-Text PDF (133 KB)
Reply, 01 June 2009 Francis Y. Yao, John P. Roberts page 377 Preview | Full Text | Full-Text PDF (125 KB)
“Adjuvant” Therapy after Endoscopic Mucosal Resection of Early Gastric Cancer, 01 June 2009 James J. Farrell pages 377-379 Preview | Full Text | Full-Text PDF (151 KB)
A New Answer to an Old Question: Azathioprine Withdrawal in Quiescent Crohn's Disease, 01 June 2009 Justin L. Sewell, Uma Mahadevan pages 379-381 Preview | Full Text | Full-Text PDF (151 KB)
Intestinal Microbiota Gives a Nod to the Hygiene Hypothesis in Type 1 Diabetes, 01 June 2009 Rodrigue Dessein, Laurent Peyrin-Biroulet, Mathias Chamaillard pages 381-383 Preview | Full Text | Full-Text PDF (153 KB)
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