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Cover 1
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OFC
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| Covering the Cover |
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Covering the Cover
19 December 2011
Tobacco remains the most preventable cause of death in the world. Evidence supporting a carcinogenic role for tobacco has now expanded to 18 cancers. In this issue of Gastroenterology, 2 studies provi...
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Anson W. Lowe,
Richard H. Moseley
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191-193
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| Comment From the Editor |
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How Good Is Your Dentist? How Good Is Your Endoscopist? The Quality Imperative
19 December 2011
Recently, I polled my GI friends to determine how they selected their dentist, and whether their dentist practiced “high-quality” dentistry. Most had received recommendations from friends, and selecte...
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David Lieberman
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194-196
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| Mentoring, Education, and Training Corner |
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Writing and Publishing Scientific Papers
19 December 2011
Published scientific papers are essential to disseminate research findings, and publications are a measure of academic productivity assessed for promotion and grant application. However, these are not...
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Hashem B. El–Serag
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197-200
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AGA Gastroenterology Training Exam (GTE): A Progress Report
19 December 2011
Subspecialty fellowship program directors (PDs) are keenly interested in monitoring and enhancing their trainees' academic progress throughout their fellowship experience. In addition to assessing tra...
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Gregory S. Sayuk,
Ikuo Hirano,
James T. Fitzgerald,
R. Brent Stansfield,
Betty A. Armbruster,
Tamara N. Jones,
Joy Akinyi,
Charles E. Willis,
AGA Institute's GTE Subcommittee
et al.
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201-204.e2
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| Editorials |
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Diverticulosis and Dietary Fiber: Rethinking the Relationship
19 December 2011
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Lisa L. Strate
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205-207
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Outcomes Among Living Liver Donors
26 December 2011
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James F. Trotter,
James E. Everhart
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207-210
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| Clinical Challenges and Images in GI |
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Pages |
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A Ghost Pancreas
21 December 2011
Question: A 73-year-old man without medical history was admitted to the Intensive Care Unit (ICU) for shock. The day before ICU admission, he suddenly experienced nausea and abdominal pain, and vomite...
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Arnaud Galbois,
Fabien Stenard,
Dimitri Margetis
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211
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An Unusual Cause of Upper Gastrointestinal Bleeding
21 December 2011
Question: A 45-year-old man presented to the hospital with coffee ground emesis, melena, and syncope. Initial evaluation revealed signs of hemodynamic instability with a heart rate of 120 beats/min an...
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Ahmad ALHarbi,
Majid Almadi,
Andrew Szilagyi
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211
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The Way to a Man's Stomach Is Through His Heart
21 December 2011
Question: A 74-year-old man underwent gastroscopy owing to severe nausea, vomitus, and fluctuating mild epigastric discomfort of 2 months' duration. He had known chronic renal failure with a creatinin...
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Luc Biedermann,
Ariana Gaspert,
Christoph Gubler
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212
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Emphysematous Changes of the Liver
21 December 2011
Question: A 59-year-old woman presented to the emergency department with nausea and epigastric pain for 2 days preceded by 2 weeks of anorexia. Several years ago, she was diagnosed as glucose intolera...
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Yang–Sheng Lin,
Wei–Sheng Wang,
Ming–Jen Chen
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213
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| Electronic Clinical Challenges and Images in GI |
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To Snare a Snare, or Not to Snare?
22 December 2011
Question: A 79-year-old man presented with a 1-year history of intermittent colicky abdominal pain, without rectal blood loss or fever. On physical examination, the abdomen was not distended, there we...
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Stijn J.B. Van Weyenberg
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e1-e2
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An Uncommon Cause of Epigastric Pain and Emesis
22 December 2011
Question: A 35-year-old man presented to our gastrointestinal clinic with a 4-week history of sudden onset emesis and upper abdominal pain in the right epigastrium. Alarming symptoms, such as dysphagi...
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Doerthe Kuester,
Christian Schulz,
Peter Malfertheiner
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e3-e5
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A Rare but Important Cause of Acute Abdomen
22 December 2011
Question: A 33-year-old man with history of right inguinal hernia presented with progressive abdominal pain for 1 week. On examination he had a soft right inguinal mass with diffuse peritonitis, and l...
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Wan-Ling Miriam Wu,
I-Ha Lao
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e6-e7
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Upper Gastrointestinal Bleeding in a Patient With Multiple Myeloma
22 December 2011
Question: A 53-year-old African American woman was diagnosed with κ-light chain multiple myeloma in 2005. She underwent chemotherapy previously, and stem cell transplantation 4 months before the curre...
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Sumanth R. Daram,
Elizabeth R. Paine,
Amanda F. Swingley
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e8-e9
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Large Tumor of the Liver and Hypoglycemic Shock in an 85-Year-Old Patient
23 December 2011
Question: An 85-year-old woman was referred to our institution with a palpable mass in the upper abdomen. Her past medical history was unremarkable except for arterial hypertension and coronary artery...
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Sonia Radunz,
Hideo A. Baba,
Georgios C. Sotiropoulos
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e10-e11
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Vague Abdominal Discomfort for 5 Years and a Large Upper Abdominal Mass in a 45-Year-Old Woman
26 December 2011
Question: A 45-year-old woman with a history of a gastric ulcer 10 years ago presented to the outpatient department with vague upper abdominal discomfort for 5 years. She had no history of abdominal s...
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Jiann–Hwa Chen,
Chung–Tai Yue,
Chieh–Wen Lai
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e12-e13
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Transient Ischemic Attack in a Patient With Cirrhosis
23 December 2011
Question: A 63-year-old man presented with acute onset of slurred of speech that resolved within a few hours. He was recently diagnosed with cirrhosis secondary to hepatitis C and alcohol. He had lost...
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Jagrati Mathur,
David Limsui
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e14-e15
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A Common Disease With an Unusual Complication of Acute Abdomen
22 December 2011
Question: A previously healthy 64-year-old man presented to the emergency department with a 4-day duration of progressive and diffuse abdominal pain. The pain, seemingly unrelated to meals or postural...
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Jui-Shan Hsu,
I-Hui Wu,
Kao-Lang Liu
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e16-e18
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Dysphagia in an HIV Patient: A Rare Culprit
22 December 2011
Question: A 37-year-old Caucasian woman sought medical attention for intermittent dysphagia for both liquids and solids, loss of appetite, and a 5-kg weight loss in the past 3 months. She denied other...
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Ana Gonçalves,
Teresa Antunes
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e19-e20
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Bleeding Polyps?
23 December 2011
Question: A 60-year-old Caucasian woman presented with melena of 3 days' duration. It was the second episode of gastrointestinal (GI) bleeding. Fourteen days ago, colonoscopy done in another hospital ...
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Martin Wilhelmi,
Pablo Munoz,
Maria-Anna Ortner
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e21-e22
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An Extremely Unusual and Large Cause of Anemia
22 December 2011
Question: A 63-year-old man with a long-standing medical history of anemia presented to the gastroenterology outpatient clinic with diffuse abdominal pain, progressive dragging sensation in the left u...
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Javier G. Castillo,
Dana Telem,
Tomas M. Heimann
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e23-e24
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| Reviews and Perspectives |
| Imaging and Advanced Technology |
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Myc Target miRs and Liver Cancer: Small Molecules to Get Myc Sick
19 December 2011
Primary liver cancer is a disease arising from malignant transformation of hepatocytes, which account for up to 80% of the liver tissue. In infants, the most common form of liver tumor is hepatoblasto...
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Marie–Annick Buendia,
Ludovic Bourre,
Stefano Cairo
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214-218
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| Reviews in Basic and Clinical Gastroenterology and Hepatology |
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Dysregulation of Wnt/β-Catenin Signaling in Gastrointestinal Cancers
09 December 2011
Aberrant Wnt/β-catenin signaling is widely implicated in numerous malignancies, including cancers of the gastrointestinal tract. Dysregulation of signaling is traditionally attributed to mutations in ...
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Bryan D. White,
Andy J. Chien,
David W. Dawson
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219-232
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| Original Research |
| Clinical-Alimentary Tract |
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Tobacco Smoking Increases the Risk of High-Grade Dysplasia and Cancer Among Patients With Barrett's Esophagus
07 November 2011
Background & Aims: Esophageal adenocarcinoma arises from Barrett's esophagus (BE); patients with this cancer have a poor prognosis. Identification of modifiable lifestyle factors that affect the r...
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Helen G. Coleman,
Shivaram Bhat,
Brian T. Johnston,
Damian McManus,
Anna T. Gavin,
Liam J. Murray
et al.
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233-240
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Smoking Increases the Risk for Colorectal Adenomas in Patients With Lynch Syndrome
07 November 2011
Background & Aims: Individuals with Lynch syndrome have a high risk of developing colorectal carcinomas and adenomas at a young age, due to inherited mutations in mismatch repair genes. We investi...
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Renate M. Winkels,
Akke Botma,
Fränzel J.B. Van Duijnhoven,
Fokko M. Nagengast,
Jan H. Kleibeuker,
Hans F.A. Vasen,
Ellen Kampman
et al.
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241-247
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Next-Generation Stool DNA Test Accurately Detects Colorectal Cancer and Large Adenomas
07 November 2011
Background & Aims: Technical advances have led to stool DNA (sDNA) tests that might accurately detect neoplasms on both sides of the colorectum. We assessed colorectal neoplasm detection by a next...
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David A. Ahlquist,
Hongzhi Zou,
Michael Domanico,
Douglas W. Mahoney,
Tracy C. Yab,
William R. Taylor,
Malinda L. Butz,
Stephen N. Thibodeau,
Linda Rabeneck,
Lawrence F. Paszat,
Kenneth W. Kinzler,
Bert Vogelstein,
Niels Chr. Bjerregaard,
Søren Laurberg,
Henrik Toft Sørensen,
Barry M. Berger,
Graham P. Lidgard
et al.
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248-256
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Adalimumab Induces and Maintains Clinical Remission in Patients With Moderate-to-Severe Ulcerative Colitis
07 November 2011
Background & Aims: Adalimumab is a fully human monoclonal antibody that binds tumor necrosis factor (TNF)-α. Its efficacy as maintenance therapy for patients with ulcerative colitis has not been s...
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William J. Sandborn,
Gert van Assche,
Walter Reinisch,
Jean–Frederic Colombel,
Geert D'Haens,
Douglas C. Wolf,
Martina Kron,
Mary Beth Tighe,
Andreas Lazar,
Roopal B. Thakkar
et al.
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257-265.e3
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A High-Fiber Diet Does Not Protect Against Asymptomatic Diverticulosis
07 November 2011
Background & Aims: The complications of diverticulosis cause considerable morbidity in the United States; health care expenditures for this disorder are estimated to be $2.5 billion per year. Many...
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Anne F. Peery,
Patrick R. Barrett,
Doyun Park,
Albert J. Rogers,
Joseph A. Galanko,
Christopher F. Martin,
Robert S. Sandler
et al.
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266-272.e1
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| Clinical-Liver |
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Estimates of Early Death, Acute Liver Failure, and Long-term Mortality Among Live Liver Donors
21 November 2011
Background & Aims: We sought to estimate the risk of perioperative mortality or acute liver failure for live liver donors in the United States and avoid selection or ascertainment biases and sampl...
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Abimereki D. Muzaale,
Nabil N. Dagher,
Robert A. Montgomery,
Sarah E. Taranto,
Maureen A. Mcbride,
Dorry L. Segev
et al.
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273-280
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| Basic and Translational-Alimentary Tract |
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Article Title |
Author(s) |
Pages |
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Helicobacter pylori Infection Recruits Bone Marrow−Derived Cells That Participate in Gastric Preneoplasia in Mice
07 November 2011
Background & Aims: Studies in animal models have shown that bone marrow−derived cells (BMDC) could be involved in the formation of carcinomas of the upper gastrointestinal tract, including gastric...
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Christine Varon,
Pierre Dubus,
Frédéric Mazurier,
Corinne Asencio,
Lucie Chambonnier,
Jonathan Ferrand,
Alban Giese,
Nathalie Senant–Dugot,
Martina Carlotti,
Francis Mégraud
et al.
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281-291
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Deficiency of Claudin-18 Causes Paracellular H+ Leakage, Up-regulation of Interleukin-1β, and Atrophic Gastritis in Mice
11 November 2011
Background & Aims: Although defects in tight junction (TJ) epithelial paracellular barrier function are believed to be a primary cause of inflammation, the mechanisms responsible remain largely un...
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Daisuke Hayashi,
Atsushi Tamura,
Hiroo Tanaka,
Yuji Yamazaki,
Shin Watanabe,
Koya Suzuki,
Kazuo Suzuki,
Kazuhiro Sentani,
Wataru Yasui,
Hiromi Rakugi,
Yoshitaka Isaka,
Sachiko Tsukita
et al.
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292-304
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Inflammation and Disruption of the Mucosal Architecture in Claudin-7–Deficient Mice
31 October 2011
Background & Aims: Integrity of the intestinal epithelium is required for nutrition absorption and defense against pathogens. Claudins are cell adhesion molecules that localize at tight junctions ...
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Lei Ding,
Zhe Lu,
Oded Foreman,
Rodney Tatum,
Qun Lu,
Randall Renegar,
Jian Cao,
Yan–Hua Chen
et al.
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305-315
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The Copolymer P(HEMA-co-SS) Binds Gluten and Reduces Immune Response in Gluten-Sensitized Mice and Human Tissues
11 November 2011
Background & Aims: Copolymers of hydroxyethyl methacrylate and styrene sulfonate complex with isolated gliadin (the toxic fraction of gluten) and prevent damage to the intestinal barrier in HLA-HC...
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Maud Pinier,
Gregor Fuhrmann,
Heather J. Galipeau,
Nathalie Rivard,
Joseph A. Murray,
Chella S. David,
Hana Drasarova,
Ludmila Tuckova,
Jean–Christophe Leroux,
Elena F. Verdu
et al.
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316-325.e12
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Dysregulation of CD1d-Restricted Type II Natural Killer T Cells Leads to Spontaneous Development of Colitis in Mice
03 November 2011
Background & Aims: CD1d-restricted natural killer (NK) T cells are a subset of immunoregulatory T cells that comprise type I (express the semi-invariant T-cell receptor [TCR] and can be detected u...
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Chia–Min Liao,
Michael I. Zimmer,
Sharmila Shanmuganad,
Hon–Tsen Yu,
Susanna L. Cardell,
Chyung–Ru Wang
et al.
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326-334.e2
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CCL17 Promotes Intestinal Inflammation in Mice and Counteracts Regulatory T Cell–Mediated Protection From Colitis
03 November 2011
Background & Aims: Priming of T cells by dendritic cells (DCs) in the intestinal mucosa and associated lymphoid tissues helps maintain mucosal tolerance but also contributes to the development of ...
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Alexander F. Heiseke,
Antonia C. Faul,
Hans–Anton Lehr,
Irmgard Förster,
Roland M. Schmid,
Anne B. Krug,
Wolfgang Reindl
et al.
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335-345
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Severe Defects in Absorptive Ion Transport in Distal Colons of Mice That Lack ClC-2 Channels
11 November 2011
Background & Aims: The fluid secretion model predicts that intestinal obstruction disorders can be alleviated by promoting epithelial Cl− secretion. The adenosine 3′,5′-cyclic monophosphate (cAMP)...
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Marcelo A. Catalán,
Carlos A. Flores,
Mireya González–Begne,
Yan Zhang,
Francisco V. Sepúlveda,
James E. Melvin
et al.
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346-354
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| Basic and Translational-Liver |
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Author(s) |
Pages |
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Selective Activation of Nuclear Bile Acid Receptor FXR in the Intestine Protects Mice Against Cholestasis
03 November 2011
Background & Aims: Cholestasis is a liver disorder characterized by impaired bile flow, reduction of bile acids (BAs) in the intestine, and retention of BAs in the liver. The farnesoid X receptor ...
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Salvatore Modica,
Michele Petruzzelli,
Elena Bellafante,
Stefania Murzilli,
Lorena Salvatore,
Nicola Celli,
Giuseppe Di Tullio,
Giuseppe Palasciano,
Tarek Moustafa,
Emina Halilbasic,
Michael Trauner,
Antonio Moschetta
et al.
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355-365.e4
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CCR9+ Macrophages Are Required for Acute Liver Inflammation in Mouse Models of Hepatitis
11 November 2011
Background & Aims: Antigen-presenting cells (APCs) are involved in the induction of liver inflammation. We investigated the roles of specific APCs in the pathogenesis of acute liver injury in mice...
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Nobuhiro Nakamoto,
Hirotoshi Ebinuma,
Takanori Kanai,
Po–Sung Chu,
Yuichi Ono,
Yohei Mikami,
Keisuke Ojiro,
Martin Lipp,
Paul E. Love,
Hidetsugu Saito,
Toshifumi Hibi
et al.
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366-376
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| Basic and Translational-Pancreas |
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Pages |
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The Phosphatase PHLPP1 Regulates Akt2, Promotes Pancreatic Cancer Cell Death, and Inhibits Tumor Formation
31 October 2011
Background & Aims: The kinase Akt mediates resistance of pancreatic cancer (PaCa) cells to death and is constitutively active (phosphorylated) in cancer cells. Whereas the kinases that activate Ak...
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Claudia Nitsche,
Mouad Edderkaoui,
Ryan M. Moore,
Guido Eibl,
Noriyuki Kasahara,
Janet Treger,
Paul J. Grippo,
Julia Mayerle,
Markus M. Lerch,
Anna S. Gukovskaya
et al.
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377-387.e5
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Restricted Heterochromatin Formation Links NFATc2 Repressor Activity With Growth Promotion in Pancreatic Cancer
11 November 2011
Background & Aims: Transcriptional silencing of the p15INK4b tumor suppressor pathway overcomes cellular protection against unrestrained proliferation in cancer. Here we show a novel pathway invol...
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Sandra Baumgart,
Elisabeth Glesel,
Garima Singh,
Nai–Ming Chen,
Kristina Reutlinger,
Jinsan Zhang,
Daniel D. Billadeau,
Martin E. Fernandez–Zapico,
Thomas M. Gress,
Shiv K. Singh,
Volker Ellenrieder
et al.
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388-398.e7
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| Continuing Medical Education (CME) Activity |
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Exam 1: Next-Generation Stool DNA Test Accurately Detects Colorectal Cancer and Large Adenomas
14 December 2011
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e25-e26
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| Selected Summaries |
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The Microbiota and Bariatric Surgery: It's a Bug's Life
21 December 2011
Li J, Ashrafian H, Bueter M, et al. Metabolic surgery profoundly influences gut microbial-host metabolic cross-talk. Gut 2011;60:1214–1223.
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Eileen F. Murphy,
Eamonn M.M. Quigley
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399-401
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Reply
19 December 2011
We welcome the authors' comments in relation to our article published in Gut (2011;60:1214–1223) and wish to reiterate the point that referring to the role of gut microbiota as potentially being “mere...
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Julian R. Marchesi,
Jia Li,
Elaine Holmes,
Hutan Ashrafian,
Thanos Athanasiou,
Ara Darzi,
Jeremy K. Nicholson
et al.
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401-402
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Stimulant Laxatives for the Treatment of Chronic Constipation: Is it Time to Change the Paradigm?
21 December 2011
Kamm MA, Mueller-Lissner S, Wald A, et al. Oral bisacodyl is effective and well-tolerated in patients with chronic constipation. Clin Gastroenterol Hepatol 2011;9:577–583.
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Darren M. Brenner
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402-404
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Inflammatory Bowel Disease and Thromboembolism: A C‘Lot’ to Worry About
21 December 2011
Kappelman MD, Horvath-Puho E, Sandler RS, et al. Thromboembolic risk among Danish children and adults with inflammatory bowel diseases: a population-based nationwide study. Gut 2011;60:937–943.
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Joshua Max,
Akbar K. Waljee
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404-405
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Irritable Bowel Syndrome: A Dysfunction of the Endocannabinoid System?
21 December 2011
Park JM, Choi MG, Cho YK. Cannabinoid receptor 1 gene polymorphism and irritable bowel syndrome in the Korean population: a hypothesis-generating study. J Clin Gastroenterol 2011;45:45–49.
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Martin Storr,
Hans–Dieter Allescher
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406-408
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| Print and Digital Media Reviews |
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Controversies in Hepatology: The Experts Analyze Both Sides
22 December 2011
The field of hepatology has grown exponentially over the past 40 years both in the clinical and research arenas. This has accompanied the world-wide recognition of the burden of chronic liver disease...
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Paul Y. Kwo
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409
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Endoscopic Ultrasound: An Introductory Manual and Atlas, 2nd edition
19 December 2011
Endoscopic ultrasound (EUS) has emerged as a valuable diagnostic imaging modality since its introduction >30 years ago. There remains a need for enhanced EUS training that is not fully met by dedi...
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Michael J. Levy
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410
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Curbside Consultation in GI Cancer for the Gastroenterologist: 49 Clinical Questions
22 December 2011
This is another issue of the successful “Curbside Consultation” textbook series published by SLACK Incorporated. This new addition to the series focuses on the area of gastrointestinal cancers and is...
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Neil Gupta,
Sreenivasa Jonnalagadda
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410-411
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Correction
09 January 2012
Polyak SJ, Morishima C, Scott JD, et al. A summary of the 18th international symposium on hepatitis C virus and related viruses. Gastroenterology 2012;142:e1–e5.
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411
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| Correspondence |
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Estrogen Regulates the Human Duodenal Bicarbonate Secretion: Interesting Facts
21 December 2011
We enjoyed reading the recently published article “Estrogen Regulation of Duodenal Bicarbonate Secretion and Sex-Specific Protection of Human Duodenum” by Tuo et al. We congratulate the investigators ...
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Srijit Das,
R. Sakthiswary
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e29
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Reply
21 December 2011
We thank Drs Das and Rajalingham for their interests and thoughtful comments on our article, and also would like to answer their questions and concerns on our paper. Peptic ulcers, especially duodenal...
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Biguang Tuo,
Hui Dong
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e29-e30
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Estrogen Regulation of Duodenal Bicarbonate Secretion
21 December 2011
In the September 2011 issue of Gastroenterology, Tuo et al demonstrated that the well-known rarity of duodenal ulcer in premenopausal women was associated with decreased duodenal bicarbonate secretion...
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Jeremy Hugh Baron
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e30-e31
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Reply
19 December 2011
We thank Dr Baron for his interest in our article “Estrogen Regulation of Duodenal Bicarbonate Secretion and Sex-Specific Protection of Human Duodenum” published recently in Gastroenterology.
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Biguang Tuo,
Hui Dong
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e31
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Noninvasive Parameters for Predicting Esophageal Varices in Children: Their Sequential Use Provides the Best Accuracy
19 December 2011
We read with great interest the paper by Gana et al regarding the prognostic value of the clinical predictive rule (CPR) in children at risk of esophagogastric varices (EGV). The authors studied 108 c...
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Antonio Colecchia,
Davide Festi,
Anna Rita di Biase
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e32
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Reply
21 December 2011
We thank Colecchia et al for their comments in connection with our study, in which we demonstrated that common blood work and imaging variables can be utilized for estimating the likelihood of the pre...
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Juan Cristóbal Gana,
Dan Turner,
Simon C. Ling
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e32-e33
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| Frontmatter |
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Editorial Board
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A2
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Table of Contents
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A9-A12
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Information for Authors and Readers
Gastroenterology is the premiere journal in the field of gastrointestinal disease and is led by an internationally renowned board of editors. As the official journal of the AGA Institute, Gastroentero...
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A19-A20
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