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Article Title |
Author(s) |
Type (Status) |
Available Online |
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Unusual Thyroid Tumors in a Young Woman
DOI: 10.1053/j.gastro.2011.08.003
Question: A 24-year-old woman was referred to our hospital because of thyroid nodules. Physical examination revealed a painless nodule in the right lobe of the thyroid but no abnormal findings in the ...
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Kentaro Yamashita,
Yoshiaki Arimura,
Yasuhisa Shinomura
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Discussion
(In Press Uncorrected Proof)
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30 January 2012 |
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Abnormal Activation of Autophagy-Induced Crinophagy in Paneth Cells from Patients with Crohn's Disease Short title: Crinophagy in Crohn’s disease
DOI: 10.1053/j.gastro.2012.01.031
Abstract: ATG16L1, IRGM, and NOD2 regulate autophagy, and variants in these genes have been associated with predisposition to Crohn's disease (CD). However, little is known about the role of autophagy...
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Elodie Thachil,
Jean-Pierre Hugot,
Brigitte Arbeille,
Régine Paris,
Alain Grodet,
Michel Peuchmaur,
Patrice Codogno,
Frédérick Barreau,
Eric Ogier-Denis,
Dominique Berrebi,
Jérôme Viala
et al.
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Full-length article
(In Press Accepted Manuscript)
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30 January 2012 |
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Curbside Consultation in IBS
DOI: 10.1053/j.gastro.2012.01.022
Designed as a reference guide for practitioners from primary care physicians to gastroenterologists, Curbside Consultation in IBS is designed for rapid reference and readability, addressing primary q...
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Baha Moshiree
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Book review
(In Press Uncorrected Proof)
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27 January 2012 |
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Forgotten Ileus
DOI: 10.1053/j.gastro.2011.09.004
Question: A 26-year-old man was referred to our hospital for obstinate constipation unresponsive to chronic laxatives therapy. On admission he had no appetite, and experienced nausea, vomiting, and cr...
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Vitale José,
Edoardo Fesce,
Giancarlo Schmidt
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Discussion
(In Press Uncorrected Proof)
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27 January 2012 |
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An Unusual Cause of Acute Pancreatitis in a 6-Year-Old Boy
DOI: 10.1053/j.gastro.2011.08.045
Question: A 6-year-old boy presented with periumbilical abdominal pain, nausea, and hematemesis. On physical examination, the abdomen was soft and mildly distended in the epigastric region, with local...
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Shohei Honda,
Hisayuki Miyagi,
Tadao Okada
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Discussion
(In Press Uncorrected Proof)
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27 January 2012 |
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Hepatic Mass in a 73-Year-Old Man
DOI: 10.1053/j.gastro.2011.09.006
Question: A 73-year-old man with history of hypertension and dyslipidemia was incidentally found to have a large liver mass on magnetic resonance imaging. He did not have a personal or family history ...
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Jaclyn F. Hechtman,
Mohammad Raoufi,
M. Isabel Fiel
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Discussion
(In Press Uncorrected Proof)
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27 January 2012 |
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A Bad Streak
DOI: 10.1053/j.gastro.2011.07.031
Question: A 59-year-old Cambodian man, a resident of the United States for 25 years, presented with fatigue, early satiety, and intermittent abdominal discomfort. Physical examination revealed tender,...
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Seth Sweetser,
Nataliya Razumilava,
Patrick S. Kamath
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Discussion
(In Press Uncorrected Proof)
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27 January 2012 |
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Successful Training in Gastrointestinal Endoscopy
DOI: 10.1053/j.gastro.2012.01.023
Successful Training in Gastrointestinal Endoscopy, edited by Jonathan Cohen, is a hard-bound textbook with accompanying DVD of instructional video clips that is designed to provide a comprehensive exa...
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Herbert C. Wolfsen,
Lesley A. houghton,
Lois Hemminger
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Book review
(In Press Uncorrected Proof)
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27 January 2012 |
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Acing the Hepatology Questions on the GI Board Exam: The Ultimate Crunch-Time Resource
DOI: 10.1053/j.gastro.2012.01.024
Preparing for the GI board examination is a daunting and overwhelming task, both for new graduates making the tough transition from fellowship to faculty, as well as busy clinicians preparing for the ...
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Mohammad S. Siddiqui,
Richard K. Sterling
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Book review
(In Press Uncorrected Proof)
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27 January 2012 |
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Pigmentation Sparing on Melanosis Coli
DOI: 10.1053/j.gastro.2011.07.032
Question: A 91-year man visited our outpatient clinic because of chronic constipation for decades and more recent tenesmus. For the chronic constipation, he had been taking sennosides laxatives for 40...
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Chien-Yuan Hung,
Li-Rung Shyung,
Ming-Jen Chen
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Discussion
(In Press Uncorrected Proof)
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27 January 2012 |
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An Unusual Oral Mass
DOI: 10.1053/j.gastro.2011.08.047
Question: A 72-year-old man with a recent history of dental crown placement and a root canal procedure complaints of right-sided mouth pain, numbness, and lip paresthesia. A mandibular lytic lesion wa...
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Lorenzo Mannelli,
Mai Vi H. Hoang,
Annette P. Sabath,
Ken F. Linnau
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Discussion
(In Press Uncorrected Proof)
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27 January 2012 |
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Covering the Cover
DOI: 10.1053/j.gastro.2012.01.008
Congenital short-bowel syndrome represents a developmental anomaly in which the intestinal tract is foreshortened to the extent that nutrient assimilation is compromised. This rare syndrome exhibits a...
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Anson Lowe,
Richard H. Moseley
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Discussion
(In Press Uncorrected Proof)
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27 January 2012 |
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Villin-Marked Gastric Progenitor Cells: Conveyors or Purveyors of Precancerous Change?
DOI: 10.1053/j.gastro.2012.01.012
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Deborah L. Gumucio,
Jonathan P. Katz
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Editorial
(In Press Uncorrected Proof)
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27 January 2012 |
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Unusual Cause of a Massive Abdominal Cystic Tumor
DOI: 10.1053/j.gastro.2011.08.046
Question: A 74-year-old Chinese woman presented to the gastroenterology unit with a 3-day history of abdominal distension. This was associated with intractable vomiting and an inability to tolerate fo...
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Esther S.T. Ng,
Sarika Gupta,
Pei Jye Voon
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Discussion
(In Press Uncorrected Proof)
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27 January 2012 |
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Is HCV Infection a Neurologic Disorder?
DOI: 10.1053/j.gastro.2012.01.010
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Cyrille Féray
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Editorial
(In Press Uncorrected Proof)
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27 January 2012 |
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Gastric Sonic Hedgehog Acts as a Macrophage Chemoattractant During the Immune Response to Helicobacter pylori
DOI: 10.1053/j.gastro.2012.01.029
Abstract: Background & Aims: Macrophages mediate the epithelial response to Helicobacter pylori and are involved in the development of gastritis. Sonic Hedgehog (Shh) regulates gastric epithelial ...
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Michael A. Schumacher,
Jessica M. Donnelly,
Amy C. Engevik,
Chang Xiao,
Li Yang,
Susan Kenny,
Andrea Varro,
Frédéric Hollande,
Linda C. Samuelson,
Yana Zavros
et al.
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Full-length article
(In Press Accepted Manuscript)
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27 January 2012 |
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Risk for Immune-Mediated Graft Dysfunction in Liver Transplant Recipients with Recurrent HCV Infection Treated with Pegylated Interferon
DOI: 10.1053/j.gastro.2012.01.030
Abstract: Background & Aims: Patients with recurrent hepatitis C virus infection treated with pegylated interferon (PEG) after liver transplantation can develop severe immune-mediated graft dysfun...
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Josh Levitsky,
Maria Isabel Fiel,
John P. Norvell,
Edward Wang,
Kymberly D. Watt,
Michael P. Curry,
Sumeet Tewani,
Timothy M. McCashland,
Maarouf A. Hoteit,
Abraham Shaked,
Samuel Saab,
Amanda C. Chi,
Amy Tien,
Thomas D. Schiano
et al.
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Full-length article
(In Press Accepted Manuscript)
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27 January 2012 |
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Hepatic Cell-Specific Gene Expression Better Predicts HCV Treatment Outcome than IL28B Genotype
DOI: 10.1053/j.gastro.2012.01.028
Abstract: Background: Cell-specific expression patterns of hepatic interferon-stimulated genes (ISGs) and single-nucleotide polymorphisms (SNPs) near the IL28B gene are associated with response to int...
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Ian McGilvray,
Jordan J. Feld,
Limin Chen,
Venessa Pattullo,
Maha Guindi,
Sandra Fischer,
Ivan Borozan,
Gang Xie,
Nazia Selzner,
E. Jenny Heathcote,
Katherine Siminovitch
et al.
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Full-length article
(In Press Accepted Manuscript)
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27 January 2012 |
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Can Surrogate Endpoints From a First-Round Screening Be Reliable for Colorectal Cancer Screening?
DOI: 10.1053/j.gastro.2011.11.056
Wilschut et al use a simulation model that suggests that fecal immunochemical test was most effective with a 50 ng/mL cutoff level. Their simulation model used the detection rates obtained from robust...
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Alain Braillon
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Correspondence
(In Press Uncorrected Proof)
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25 January 2012 |
|
Reply
DOI: 10.1053/j.gastro.2012.01.026
We thank Dr Hitoshi Asakura for his thoughtful comments on regarding our study for the comparative genetic association study between ulcerative colitis (UC) and Crohn's disease (CD), in which we repor...
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Yukinori Okada,
Michiaki Kubo
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Correspondence
(In Press Uncorrected Proof)
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25 January 2012 |
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HLA-Cw*1202-B*5201-DRB1*1502 Haplotype Increases Risk for Ulcerative Colitis but Reduces Risk for Crohn's Disease
DOI: 10.1053/j.gastro.2011.10.044
In the September 2011 issue of Gastroenterology, Okada et al reported that the HLA-Cw*1202-B*5201-DRB1*1502 haplotype increased risk for ulcerative colitis, but reduced risk for Crohn's disease, based...
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Hitoshi Asakura
|
Correspondence
(In Press Uncorrected Proof)
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25 January 2012 |
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Fibroblast Growth Factor 19, An Anticholestatic Drug Produced by Human Liver
DOI: 10.1053/j.gastro.2012.01.027
In a remarkably lucid study, Modica et al conclude that activation of the nuclear farnesoid-x receptor (Fxr) in the intestine protects the liver from cholestatic injury. This seems to work fine in mic...
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Peter L.M. Jansen,
Frank G. Schaap,
Ulrich H.W. Beuers
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Correspondence
(In Press Uncorrected Proof)
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25 January 2012 |
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An Unusual Etiology of Lower Abdominal Pain in a Young Adult
DOI: 10.1053/j.gastro.2011.08.044
Question: A 32-year-old man presented with intermittent lower abdominal pain of 2 weeks' duration. He was treated at a local medical clinic, but the symptom did not improve completely after medication...
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Kuo–Feng Hsu,
Yuan–Ming Tsai,
Yao–Chi Liu
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Discussion
(In Press Uncorrected Proof)
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25 January 2012 |
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A Child With Diarrhea and Recurrent Otitis
DOI: 10.1053/j.gastro.2011.07.030
Question: A 5-year-old boy presented with chronic diarrhea and recurrent otitis media for 3 years. His past medical history was otherwise unremarkable. On physical examination, the patient appeared ch...
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Klaus Mönkemüller,
Lucia C. Fry,
Mattias Heiduk
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Discussion
(In Press Uncorrected Proof)
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25 January 2012 |
|
Reply
DOI: 10.1053/j.gastro.2012.01.025
Vincenzo Cardinale and Domenico Alvaro hypothesize that autosomal-dominant polycystic kidney disease (ADPKD)cholangiocytes heterozygous for PKD1 or PKD2 respond to estrogens with increased cell prolif...
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Manoe J. Janssen,
Joost P.H. Drenth
|
Correspondence
(In Press Uncorrected Proof)
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25 January 2012 |
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Comparing Fecal Immunochemical Testing: Improved Standardization Is Needed
DOI: 10.1053/j.gastro.2012.01.015
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James E. Allison,
Callum G. Fraser,
Stephen P. Halloran,
Graeme P. Young
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Editorial
(In Press Uncorrected Proof)
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25 January 2012 |
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Irritable Bowel Syndrome and Gluten Sensitivity Without Celiac Disease: Separating The Wheat From The Chafe
DOI: 10.1053/j.gastro.2012.01.020
Biesiekierski JR, Newnham ED, Irving PM, et al. (Monash University, Victoria, Australia.) Gluten causes gastrointestinal symptoms in subjects without celiac disease: a double-blind randomized placebo-...
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Courtney Ferch,
William D. Chey
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Discussion
(In Press Uncorrected Proof)
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25 January 2012 |
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Individualized Screening for Colorectal Cancer: One Size Does Not Fit All
DOI: 10.1053/j.gastro.2012.01.021
Gross CP, Soulos PR, Ross JS, et al. (Yale School of Medicine, Section of General Internal Medicine, New Haven, Connecticut). Assessing the impact of screening colonoscopy on mortality in the Medicare...
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Sameer D. Saini
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Discussion
(In Press Uncorrected Proof)
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25 January 2012 |
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Fast Routes to New Therapies: What Do Epilepsy And Inflammatory Bowel Disease Have In Common?
DOI: 10.1053/j.gastro.2012.01.018
Dudley JT, Sirota M, Shenoy M, et al. (Division of Systems Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, California). Computational repositioning of the anticon...
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Ashish Nimgaonkar,
Shamita B. Shah
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Discussion
(In Press Uncorrected Proof)
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25 January 2012 |
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Environmental Contribution to Pathogenesis of Cyst Formation in Autosomal-Dominant Polycystic Liver Diseases
DOI: 10.1053/j.gastro.2011.10.043
We read with interest the paper by Janssen et al, which elegantly demonstrating that, among patients with polycystic liver disease (PCLD) carrying a heterozygous germline mutation in PRKCSH gene, soma...
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Vincenzo Cardinale,
Domenico Alvaro
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Correspondence
(In Press Uncorrected Proof)
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25 January 2012 |
|
Appendicitis: Can Immediate Antibiotic Treatment Still Be Withheld?
DOI: 10.1053/j.gastro.2012.01.019
Vons C, Barry C, Maitre S, et al. (Hôpital Antoine Béclère [Assistance Publique-Hôpitaux de Paris and Université Paris XI], Services de Chirurgie, Clamart, France). Amoxicillin plus clavulanic acid ve...
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Hans-Dieter Allescher
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Discussion
(In Press Uncorrected Proof)
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25 January 2012 |
|
Continuing Medical Education (CME) Activities
DOI: 10.1053/j.gastro.2012.01.016
|
|
Examination
(In Press Uncorrected Proof)
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24 January 2012 |
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Autoimmunity, intestinal lymphoid hyperplasia, and Defects in Mucosal B-Cell Homeostasis in Patients with PTEN Hamartoma Tumor Syndrome
DOI: 10.1053/j.gastro.2012.01.011
Abstract: The phosphatase and tensin homolog deleted on chromosome 10 (PTEN) regulates the phosphoinositol-3-kinase (PI3K)– AKT signaling pathway. In a series of 34 patients with PTEN mutations we des...
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Mario Heindl,
Norman Händel,
Joanne Ngeow,
Janina Kionke,
Christian Wittekind,
Manja Kamprad,
Anne Rensing-Ehl,
Stephan Ehl,
Julia Reifenberger,
Christoph Loddenkemper,
Jochen Maul,
Albrecht Hoffmeister,
Stefan Aretz,
Wieland Kiess,
Charis Eng,
Holm H. Uhlig
et al.
|
Full-length article
(In Press Accepted Manuscript)
|
24 January 2012 |
|
Translational Approaches for Pharmacotherapy Development for Acute Diarrhea
DOI: 10.1053/j.gastro.2012.01.014
A report is presented of a National Institute of Diabetes and Digestive and Kidney Diseases–sponsored single topic conference designed to determine scientific advances needed to encourage development ...
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Mark Donowitz,
David H. Alpers,
Henry J. Binder,
Thomas Brewer,
Jill Carrington,
Michael J. Grey
et al.
|
Full-length article
(In Press Uncorrected Proof)
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24 January 2012 |
|
Requirements for Clinical Implementation of Biomarkers in Barrett's Esophagus
DOI: 10.1053/j.gastro.2012.01.013
Abiomarker is a relatively recent term coined to describe a detectable indicator for the presence or future risk of disease. Biomarkers may be physiological measurements (eg, blood pressure), endoscop...
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Sibu Varghese,
Pierre Lao–Sirieix,
Rebecca C. Fitzgerald
|
Full-length article
(In Press Uncorrected Proof)
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24 January 2012 |
|
A Guide for Success as a Clinical Investigator
DOI: 10.1053/j.gastro.2012.01.009
T here are several titles given to the academic clinical researcher. Clinician–researcher and clinician–scholar are among the few. Typically they describe an individual who spends approximately 50%–75...
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Dawn Provenzale
|
Full-length article
(In Press Uncorrected Proof)
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24 January 2012 |
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FXR Protects Hepatocytes from Injury by Repressing miR-199a-3p, which Increases Levels of LKB1
DOI: 10.1053/j.gastro.2012.01.007
Abstract: Background & Aims: Hepatocyte injury occurs during liver fibrogenesis. Micro-(mi)RNAs regulate some of these processes, and some are regulated by the farnesoid X receptor (FXR). We inves...
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Chan Gyu Lee,
Young Woo Kim,
Eun Hyun Kim,
Zhipeng Meng,
Wendong Huang,
Se Jin Hwang,
Sang Geon Kim
et al.
|
Full-length article
(In Press Accepted Manuscript)
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20 January 2012 |
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Folic Acid Increases Global DNA Methylation and Reduces Inflammation to Prevent Helicobacter-Associated Gastric Cancer in Mice
DOI: 10.1053/j.gastro.2011.12.058
Abstract: Background & Aims: Previous studies have suggested that dietary folic acid (FA) can protect against certain types of cancers. However the findings have varied and the mechanisms by which...
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Tamas A. Gonda,
Young-In Kim,
Martha C. Salas,
Mary V. Gamble,
Wataru Shibata,
Sureshkumar Muthupalani,
Kyoung-Jin Sohn,
Julian Abrams,
James G. Fox,
Timothy C. Wang,
Benjamin Tycko
et al.
|
Full-length article
(In Press Accepted Manuscript)
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16 January 2012 |
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CCL2-Induced Migration and SOCS3-Mediated Activation of Macrophages Are Involved in Cerulein-Induced Pancreatitis in Mice
DOI: 10.1053/j.gastro.2011.12.054
Abstract: Background & Aims: Acute pancreatitis is a common inflammatory disease mediated by damage to acinar cells and subsequent pancreatic inflammation with recruitment of leukocytes. We invest...
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Keita Saeki,
Takanori Kanai,
Masaru Nakano,
Yuji Nakamura,
Naoteru Miyata,
Tomohisa Sujino,
Yoshiyuki Yamagishi,
Hirotoshi Ebinuma,
Hiromasa Takaishi,
Yuuichi Ono,
Kazuyoshi Takeda,
Shigenari Hozawa,
Akihiko Yoshimura,
Toshifumi Hibi
et al.
|
Full-length article
(In Press Accepted Manuscript)
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16 January 2012 |
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Increased Reprogramming Capacity of Mouse Liver Progenitor Cells, Compared with Differentiated Liver Cells, Requires the BAF Complex
DOI: 10.1053/j.gastro.2012.01.004
Abstract: Background & Aims: Ectopic expression of certain transcription factors can reprogram somatic cells to a pluripotent state. Hematopoietic stem cells can be more efficiently reprogrammed t...
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Alexander Kleger,
Pallavi Mahaddalkar,
Sarah-Fee Katz,
André Lechel,
Jin Young Ju,
Komal Loya,
Qiong Lin,
Daniel Hartmann,
Stefan Liebau,
Johann Kraus,
Tobias Cantz,
Hans A. Kestler,
Holm Zaehres,
Hans Schöler,
Karl Lenhard Rudolph
et al.
|
Full-length article
(In Press Accepted Manuscript)
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16 January 2012 |
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Frequent Detection of Pancreatic Lesions in Asymptomatic High-Risk Individuals
DOI: 10.1053/j.gastro.2012.01.005
Abstract: Background & Aims: The risk of pancreatic cancer is increased in patients with a strong family history of pancreatic cancer or a predisposing germline mutation. Screening can detect cura...
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Marcia Irene Canto,
Ralph H. Hruban,
Elliot K. Fishman,
Ihab R. Kamel,
Richard Schulick,
Zhe Zhang,
Mark Topazian,
Naoki Takahashi,
Joel Fletcher,
Gloria Petersen,
Alison P. Klein,
Jennifer Axilbund,
Constance Griffin,
Sapna Syngal,
John R. Saltzman,
Koenraad J. Mortele,
Jeffrey Lee,
Eric Tamm,
Raghunandan Vikram,
Priya Bhosale,
Daniel Margolis,
James Farrell,
Michael Goggins,
American Cancer of the Pancreas Screening (CAPS) Consortium
et al.
|
Full-length article
(In Press Accepted Manuscript)
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16 January 2012 |
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HCV Infection Induces a Unique Hepatic Innate Immune Response Associated with Robust Production of Type III Interferons
DOI: 10.1053/j.gastro.2011.12.055
Abstract: Background and Aims: Polymorphisms in the IL28B gene have been associated with clearance of hepatitis C virus (HCV), indicating a role for type III interferons (IFNs) in HCV infection. Littl...
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Emmanuel Thomas,
Veronica D. Gonzalez,
Qisheng Li,
Ankit A. Modi,
Weiping Chen,
Mazen Noureddin,
Yaron Rotman,
T. Jake Liang
et al.
|
Full-length article
(In Press Accepted Manuscript)
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16 January 2012 |
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Disruption of Notch1 Induces Vascular Remodeling, Intussusceptive Angiogenesis, and Angiosarcomas in Livers of Mice
DOI: 10.1053/j.gastro.2011.12.052
Abstract: Background & Aims: Notch signaling mediates embryonic vascular development and normal vascular remodeling; Notch1 knockout mice develop nodular regenerative hyperplasia (NRH). The pathog...
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Michael T. Dill,
Sonja Rothweiler,
Valentin Djonov,
Ruslan Hlushchuk,
Luigi Tornillo,
Luigi Terracciano,
Silvia Meili-Butz,
Freddy Radtke,
Markus H. Heim,
David Semela
et al.
|
Full-length article
(In Press Accepted Manuscript)
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16 January 2012 |
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Effects of Fractionated Plasma Separation and Adsorption on Survival in Patients with Acute-On-Chronic Liver Failure
DOI: 10.1053/j.gastro.2011.12.056
Abstract: Background & Aims: Fractionated plasma separation and adsorption (FPSA) is an extracorporeal procedure that supports liver function by removing endogenous toxins that cause complications...
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Andreas Kribben,
Guido Gerken,
Sebastian Haag,
Stefan Herget-Rosenthal,
Ulrich Treichel,
Christoph Betz,
Christoph Sarrazin,
Eric Hoste,
Hans Van Vlierberghe,
Àngels Escorsell,
Carsten Hafer,
Oliver Schreiner,
Peter R. Galle,
Elena Mancini,
Paolo Caraceni,
Constantine J. Karvellas,
Hermann Salmhofer,
Mladen Knotek,
Pere Ginès,
Justyna Kozik-Jaromin,
Kinan Rifai,
HELIOS Study Group
et al.
|
Full-length article
(In Press Accepted Manuscript)
|
16 January 2012 |
|
Duodenal Activation of cAMP-Dependent Protein Kinase Induces Vagal Afferent Firing and Lowers Glucose Production in Rats
DOI: 10.1053/j.gastro.2011.12.053
Abstract: Background & Aims: The duodenum senses nutrients to maintain energy and glucose homeostasis, but little is known about the signaling and neuronal mechanisms involved. We tested whether d...
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Brittany A. Rasmussen,
Danna M. Breen,
Ping Luo,
Grace W.C. Cheung,
Clair S. Yang,
Biying Sun,
Andrea Kokorovic,
Weifang Rong,
Tony K.T. Lam
et al.
|
Full-length article
(In Press Accepted Manuscript)
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16 January 2012 |
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Effect of IL28B Genotype on Early Viral Kinetics during Interferon-Free Treatment of Patients with Chronic Hepatitis C
DOI: 10.1053/j.gastro.2011.12.057
Abstract: Background & Aims: Although IL28B genotype affects the response of patients with chronic hepatitis C (CHC) to peginterferon and ribavirin, little is known its effect on response to direc...
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Tom W. Chu,
Rohit Kulkarni,
Edward J. Gane,
Stuart K. Roberts,
Catherine Stedman,
Peter W. Angus,
Brett Ritchie,
Xiao-Yu Lu,
David Ipe,
Uri Lopatin,
Soren Germer,
Victor A. Iglesias,
Robert Elston,
Patrick F. Smith,
Nancy S. Shulman
et al.
|
Full-length article
(In Press Accepted Manuscript)
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16 January 2012 |
|
Response of the Upper Esophageal Sphincter to Esophageal Distension is Affected by Posture, Velocity, Volume, and Composition of the Infusate
DOI: 10.1053/j.gastro.2012.01.006
Abstract: Background & Aims: Studies of the pressure response of the upper esophageal sphincter (UES) to simulated or spontaneous gastroesophageal reflux have shown conflicting results. These disc...
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Arash Babaei,
Kulwinder Dua,
Sohrab Rahimi Naini,
Justin Lee,
Omar Katib,
Ke Yan,
Raymond Hoffmann,
Reza Shaker
et al.
|
Full-length article
(In Press Accepted Manuscript)
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16 January 2012 |
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Cigarette Smoking Increases Risk of Barrett's Esophagus: an Analysis of the Barrett's and Esophageal Adenocarcinoma Consortium
DOI: 10.1053/j.gastro.2011.12.049
Abstract: Background & Aims: Cigarette smoking has been implicated in the etiology of esophageal adenocarcinoma, but it is not clear if smoking is a risk factor for Barrett’s esophagus (BE). We in...
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Michael B. Cook,
Nicholas J. Shaheen,
Lesley A. Anderson,
Carol Giffen,
Wong-Ho Chow,
Thomas L. Vaughan,
David C. Whiteman,
Douglas A. Corley
et al.
|
Full-length article
(In Press Accepted Manuscript)
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13 January 2012 |
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Body Mass Index Increases Risk for Colorectal Adenomas, Based on Meta-Analysis
DOI: 10.1053/j.gastro.2011.12.050
Abstract: Background & Aims: There have been inconsistent results published about the relationship between excess body weight, expressed as increased body mass index (BMI), and the risk of colorec...
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Qiwen Ben,
Wei An,
Ying Jiang,
Xianbao Zhan,
Yiqi Du,
Quancai Cai,
Jie Gao,
Zhaoshen Li
et al.
|
Full-length article
(In Press Accepted Manuscript)
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13 January 2012 |
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Endoscopic Ultrasound-Guided Transmural and Percutaneous Transhepatic Gallbladder Drainage are Comparable for Acute Cholecystitis
DOI: 10.1053/j.gastro.2011.12.051
Abstract: Background & Aims: Endoscopic ultrasound (EUS)-guided transmural gallbladder drainage (EUS-GBD) is an alternative to percutaneous transhepatic gallbladder drainage (PTGBD) for patients w...
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Ji-Woong Jang,
Sang-Soo Lee,
Tae Jun Song,
Yil Sik Hyun,
Do-Hyun Park,
Dong-Wan Seo,
Sung-Koo Lee,
Myung-Hwan Kim,
Sung-Cheol Yun
et al.
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Full-length article
(In Press Accepted Manuscript)
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13 January 2012 |
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Autophagy Releases Lipid That Promotes Fibrogenesis by Activated Hepatic Stellate Cells in Mice and in Human Tissues
DOI: 10.1053/j.gastro.2011.12.044
Background & Aims: The pathogenesis of liver fibrosis involves activation of hepatic stellate cells, which is associated with depletion of intracellular lipid droplets. When hepatocytes undergo au...
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Virginia Hernández–Gea,
Zahra Ghiassi–Nejad,
Raphael Rozenfeld,
Ronald Gordon,
Maria Isabel Fiel,
Zhenyu Yue,
Mark J. Czaja,
Scott L. Friedman
et al.
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Full-length article
(In Press Uncorrected Proof)
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11 January 2012 |
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Estrogen Receptor-α Represses Transcription of HBV Genes via Interaction with Hepatocyte Nuclear Factor 4α
DOI: 10.1053/j.gastro.2011.12.045
Abstract: Background & Aims: Women with hepatitis B virus (HBV) infection usually have lower viral loads than men, reducing their risk for liver cancer. There are two androgen-responsive elements ...
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Sheng-Han Wang,
Shiou-Hwei Yeh,
Wei-Hsiang Lin,
Kun-Huei Yeh,
Quan Yuan,
Ning-Shao Xia,
Ding-Shinn Chen,
Pei-Jer Chen
et al.
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Full-length article
(In Press Accepted Manuscript)
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11 January 2012 |
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RACK1 Suppresses Gastric Tumorigenesis by Stabilizing the β-Catenin Destruction Complex
DOI: 10.1053/j.gastro.2011.12.046
Abstract: Background & Aims: Dysregualtion of Wnt signaling has been involved in Gastric tumorigenesis by mechanisms that are not fully understood. The receptor for activated protein kinase C (RAC...
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Yue-Zhen Deng,
Fan Yao,
Jing-Jing Li,
Zheng-Fa Mao,
Ping-Ting Hu,
Ling-Yun Long,
Guo Li,
Xiao-Dan Ji,
Shuo Shi,
Dong-Xian Guan,
Yuan-Yuan Feng,
Lei Cui,
Dang-Sheng Li,
Yong Liu,
Xiang Du,
Ming-Zhou Guo,
Li-Yan Xu,
En-Min Li,
Hong-Yang Wang,
Dong Xie
et al.
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Full-length article
(In Press Accepted Manuscript)
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11 January 2012 |
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Strand-Specific miR-28-5p and miR-28-3p Have Distinct Effects in Colorectal Cancer Cells
DOI: 10.1053/j.gastro.2011.12.047
Abstract: Background & Aims: microRNAs (miRs) can promote or inhibit tumor growth and are therefore being developed as targets for cancer therapies. They are diverse not only in the mRNAs they tar...
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Maria I. Almeida,
Milena S. Nicoloso,
Lizhi Zeng,
Cristina Ivan,
Riccardo Spizzo,
Roberta Gafà,
Lianchun Xiao,
Xinna Zhang,
Ivan Vannini,
Francesca Fanini,
Muller Fabbri,
Giovanni Lanza,
Rui M. Reis,
Patrick A. Zweidler-McKay,
George A. Calin
et al.
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Full-length article
(In Press Accepted Manuscript)
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11 January 2012 |
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Diverse Functional Properties of Wilson Disease ATP7B Variants
DOI: 10.1053/j.gastro.2011.12.048
Abstract: Background & Aims: Wilson disease is a severe disorder of copper metabolism caused by mutations in ATP7B, which encodes a copper-transporting ATPase. The disease presents with a variable...
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Dominik Huster,
Angelika Kühne,
Ashima Bhattacharjee,
Lily Raines,
Vanessa Jantsch,
Johannes Noe,
Wiebke Schirrmeister,
Ines Sommerer,
Osama Sabri,
Frieder Berr,
Joachim Mossner,
Bruno Stieger,
Karel Caca,
Svetlana Lutsenko
et al.
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Full-length article
(In Press Accepted Manuscript)
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11 January 2012 |
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Pediatric Patients with Dyspepsia Have Chronic Symptoms, Anxiety, and Lower Quality of Life as Adolescents and Adults
DOI: 10.1053/j.gastro.2011.12.043
Abstract: Background & Aims: Little is known about long-term health outcomes of children with dyspeptic symptoms. We studied the natural history of pediatric patients with dyspeptic symptoms, with...
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Sara W. Rippel,
Sari Acra,
Hernán Correa,
Michael Vaezi,
Carlo Di Lorenzo,
Lynn S. Walker
et al.
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Full-length article
(In Press Accepted Manuscript)
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09 January 2012 |
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Presence of Somatic Mutations in Most Early-Stage Pancreatic Intraepithelial Neoplasia
DOI: 10.1053/j.gastro.2011.12.042
More information is needed about genetic factors that initiate development of pancreatic intraepithelial neoplasms—the most common precursors of pancreatic ductal adenocarcinoma. We show that more tha...
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Mitsuro Kanda,
Hanno Matthaei,
Jian Wu,
Seung–Mo Hong,
Jun Yu,
Michael Borges,
Ralph H. Hruban,
Anirban Maitra,
Kenneth Kinzler,
Bert Vogelstein,
Michael Goggins
et al.
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Full-length article
(In Press Uncorrected Proof)
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09 January 2012 |
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Enteropathy Associated T Cell Lymphoma Complicating An Autoimmune Enteropathy
DOI: 10.1053/j.gastro.2011.12.040
Abstract: Enteropathy associated T-cell lymphoma (EATL) is a rare non-hodgkin lymphoma frequently associated with celiac disease. We report a case of EATL-complicating adult autoimmune enteropathy (AI...
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Georgia Malamut,
Virginie Verkarre,
Céline Callens,
Orianne Colussi,
Gabriel Rahmi,
Elizabeth Macintyre,
Corinne Haïoun,
Bertrand Meresse,
Nicole Brousse,
Serge Romana,
Olivier Hermine,
Nadine Cerf-Bensussan,
Christophe Cellier
et al.
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Full-length article
(In Press Accepted Manuscript)
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06 January 2012 |
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Activation Of Colonic Mucosal 5-HT 4 Receptors Accelerates Propulsive Motility And Inhibits Visceral Hypersensitivity
DOI: 10.1053/j.gastro.2011.12.041
Abstract: Background & Aims: 5-HT4 receptor agonists promote gastrointestinal motility and attenuate visceral pain, but concerns about adverse reactions have restricted their availability. We test...
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Jill M. Hoffman,
Karl Tyler,
Sarah J. MacEachern,
Onesmo B. Balemba,
Anthony C. Johnson,
Elice M. Brooks,
Hong Zhao,
Greg M. Swain,
Peter L. Moses,
James J. Galligan,
Keith A. Sharkey,
Beverley Greenwood-Van Meerveld,
Gary M. Mawe
et al.
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Full-length article
(In Press Accepted Manuscript)
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06 January 2012 |
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Effects of Maternal Screening and Universal Immunization to Prevent Mother-To-Infant Transmission of HBV
DOI: 10.1053/j.gastro.2011.12.035
Abstract: Background & Aims: Mother-to-infant transmission is the major cause of hepatitis B virus (HBV) infection among immunized children. There has been much debate about screening pregnant wom...
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Huey-Ling Chen,
Lung-Huang Lin,
Fu-Chang Hu,
Jian-Te Lee,
Wen-Terng Lin,
Yao-Jung Yang,
Fu-Chen Huang,
Shu-Fen Wu,
Solomon Chih-Cheng Chen,
Wan-Hsin Wen,
Chia-Hsiang Chu,
Yen-Hsuan Ni,
Hong-Yuan Hsu,
Pei-Lin Tsai,
Cheng-Lun Chiang,
Ming-Kwang Shyu,
Ping-Ing Lee,
Feng-Yee Chang,
Mei-Hwei Chang
et al.
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Full-length article
(In Press Accepted Manuscript)
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26 December 2011 |