Current Issue September 2010, Vol. 139, No. 3
Full Table of Contents
Podcasts
VideosEditor's Essential Reading
Clinical Advances in Liver, Pancreas, and Biliary Tract
Organ Failure and Infection of Pancreatic Necrosis as Determinants of Mortality in Patients With Acute Pancreatitis 
There is no consistency between the individual studies in the literature on whether organ failure (OF) or infected pancreatic necrosis (IPN) is the main determinant of severity in acute pancreatitis. We aimed to statistically aggregate the available data and determine the pooled influence of OF and IPN on mortality in patients with acute pancreatitis.
Issue Highlights
Clinical—Alimentary Tract
Acoustic Cough—Reflux Associations in Chronic Cough: Potential Triggers and MechanismsCentral sensitization is thought to play a role in chronic cough and might explain the temporal association between cough and gastroesophageal reflux (GOR) in patients in whom non-GOR causes have been excluded. Using our novel simultaneous acoustic cough recording and impedance/pH monitoring technique, we aimed to explore this further by assessing such temporal associations and their relationship to the acidity, duration, and proximal extent of reflux and the presence of erosive disease and cough reflex sensitivity in unselected patients (ie, including non-GOR causes) with chronic cough.
Clinical—Liver, Pancreas, and Biliary Tract
- Genetic Covariance Between γ-Glutamyl Transpeptidase and Fatty Liver Risk Factors: Role of β2-Adrenergic Receptor Genetic Variation in Twins
Plasma levels of γ-glutamyl transpeptidase (GGT) are associated with risk factors for nonalcoholic fatty liver disease (NAFLD), such as dyslipidemia, insulin resistance (IR), and hypertension. Limited data exist on whether there is genetic covariance between plasma levels of GGT and NAFLD risk factors.
Basic—Alimentary Tract
- Phosphoinositide 3-Kinase Signaling Mediates β-Catenin Activation in Intestinal Epithelial Stem and Progenitor Cells in Colitis
Mechanisms responsible for crypt architectural distortion in chronic ulcerative colitis (CUC) are not well understood. Data indicate that serine/threonine protein kinase Akt (Akt) signaling cooperates with Wingless (Wnt) to activate β-catenin in intestinal stem and progenitor cells through phosphorylation at Ser552 (P-β-catenin552). We investigated whether phosphoinositide 3-kinase (PI3K) is required for Akt-mediated activation of β-catenin during intestinal inflammation.
Basic-Liver, Pancreas, and Biliary Tract
Therapeutic Liver Reconstitution With Murine Cells Isolated Long After DeathDue to the shortage of donor organs, many patients needing liver transplantation cannot receive one. For some liver diseases, hepatocyte transplantation could be a viable alternative, but donor cells currently are procured from the same sources as whole organs, and thus the supply is severely limited.
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This Month in Gastroenterology02 September 2010
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October CME Exam 2 Questions01 September 2010
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October CME Exam 1 Questions01 September 2010
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A Young Woman With Refractory GI Symptoms01 September 2010
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Persistent Right-Sided Chest Pain01 September 2010
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A Rare Complication of Chemotherapy in a 56-Year-Old Patient01 September 2010
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An Unusual Cause of Upper Gastrointestinal Bleeding01 September 2010
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Dysfunctional gastric emptying with downregulation of muscle-specific microRNAs in Helicobacter pylori-infected mice30 August 2010
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Proton Pump Inhibitor Therapy Improves Symptoms in Post Nasal Drainage30 August 2010
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NOTCH1 and NOTCH3 coordinate esophageal squamous differentiation through a CSL-dependent transcriptional network30 August 2010
Trunk Fat Is Associated With Increased Serum Levels of Alanine Aminotransferase in the United States
AGA Medical Position Statement on the Diagnosis and Management of Colorectal Neoplasia in Inflammatory Bowel Disease
