| This Month in Gastroenterology |
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This Month in Gastroenterology
26 July 2010
Celiac disease is a well-recognized cause of malabsorptive diarrhea, which responds to a strict, gluten-free diet. Untreated symptomatic celiac disease is associated with substantial morbidity and inc...
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Jan Tack,
John M. Carethers
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Discussion
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pages 701-704
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| Gastroenterology and Hepatology News |
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Rapid Test for Antibodies to Hepatitis C Virus Approved by the US Food and Drug Administration
20 July 2010
The US Food and Drug Administration (FDA) announced approval on June 25 of the first rapid blood test for antibodies to the hepatitis C virus (HCV) for individuals ≥15 years old. It is the only rapid,...
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Les Lang
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Full-length article
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page 705
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Automated Telephone Reminders Increase Colon Cancer Screenings
20 July 2010
Simple, automated telephone reminders can increase colorectal cancer (CRC) screening rates by 30%, according to a Kaiser Permanente Center for Health Research study funded by the National Cancer Insti...
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Les Lang
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Full-length article
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page 705
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National Oceanic and Atmospheric Administration, US Food and Drug Administration Continue Ramping up Efforts to Ensure Safety of Gulf of Mexico Seafood
20 July 2010
In a joint announcement June 14, 2010, the National Oceanic and Atmospheric Administration (NOAA) and the US Food and Drug Administration (FDA) said they are taking additional steps to enhance inspect...
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Les Lang
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Full-length article
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page 706
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Early Transjugular Intrahepatic Portosystemic Shunt for Acute Variceal Bleeding Lowers Treatment Failure and Mortality
20 July 2010
A study published in The New England Journal of Medicine finds that early rescue treatment with a transjugular intrahepatic portosystemic shunt (TIPS) for cirrhosis patients who are hospitalized for a...
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Les Lang
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Full-length article
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page 707
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| Mini-Reviews and Perspectives |
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Author(s) |
Type |
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Intraductal Papillary Mucinous Neoplasms of the Pancreas
20 July 2010
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Carlos Fernández–del Castillo,
N. Volkan Adsay
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Full-length article
 
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pages 708-713.e2
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| Comment From the Editor |
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Gastroenterology: A Year of Growth and Change
26 July 2010
The past 12 months have been an incredible period of growth and change for Gastroenterology. Perhaps most significantly, the impact factor increased for the second year in a row, up to 12.9 from its 2...
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Erin C. Dubnansky,
Anil K. Rustgi
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Editorial
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pages 714-715
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| Editorials |
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Author(s) |
Type |
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Chronic Cough and Gastroesophageal Reflux Disease: New Twists to the Riddle
26 July 2010
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Peter J. Kahrilas
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Editorial
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pages 716-718
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Caught in the Akt: Regulation of Wnt Signaling in the Intestine
26 July 2010
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Eric C. Anderson,
Melissa H. Wong
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Editorial
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pages 718-722
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Epithelial-to-Mesenchymal Transition in Liver Fibrosis: Dead or Alive?
05 August 2010
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Yury Popov,
Detlef Schuppan
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Editorial
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pages 722-725
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Durable Correction of Inherited Metabolic Liver Disorders Requires Preventing Transgene Off-Targeting From Gene Therapy Vectors: The Value of MicroRNAs
23 July 2010
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Gloria Gonzalez–Aseguinolaza,
Jesus Prieto
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Editorial
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pages 726-729
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Cadaveric Hepatocytes Repopulate Diseased Livers: Life After Death
26 July 2010
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David C. Hay
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Editorial
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pages 729-731
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| Clinical Challenges and Images in GI |
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Author(s) |
Type |
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A Man With Dyspnea and Hepatomegaly
26 July 2010
Question: A 55-year-old man presented with progressive dyspnea on exertion for the past month. He denied any previous systemic disease. On physical examination, an engorged jugular vein without basal ...
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Hsing-Feng Lee,
Ching-Liang Lu,
Full-Young Chang
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Discussion
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page 732
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Abdominal Pain in a Young Man With Severe Hypertension
06 August 2010
Question: A 35-year-old African-American man presented to the emergency department with a history of non radiating epigastric pain that developed abruptly after a meal 4 days prior, which had acutely ...
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Aparna Singhal,
Guy E. Torstenson,
Joseph A. Gagliardi
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Discussion
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page 733
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A Man With Loose Stool and Periumbilical Pain
26 July 2010
Question: A 36-year-old man presented with loose stool passage and periumbilical pain off and on for 3 months. On examination, well-demarcated purpuric papules and plaques were noted on his extremitie...
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Hsing-Feng Lee,
Ching-Liang Lu,
Full-Young Chang
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Discussion
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page 734
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| Electronic Clinical Challenges and Images |
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Article Title |
Author(s) |
Type |
Pages |
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A Rare Cause of Upper Gastrointestinal Bleeding
06 August 2010
Question: An 84-year-old man with a past medical history of prostate cancer and duodenal ulcer presented with right upper quadrant pain, hematochezia, and postural hypotension. Physical examination di...
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Wei-Yi Lei,
Chien-Lin Chen,
Andy Shau-Bin Chou
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Discussion
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pages e1-e2
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Lower Gastrointestinal Bleeding in a Patient With a History of Breast Cancer
06 August 2010
Question: A 43-year-old woman with history of breast cancer successfully treated with surgery and chemotherapy in 2003 was admitted because of hematochezia. The patient was well until 1 month ago, whe...
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Josué Barahona-Garrido,
Gustavo López-Arce,
Sergio Criales
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Discussion
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pages e3-e5
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A Necrotic Liver Mass
06 August 2010
Question: A 54-year-old woman presented with a mass in the upper abdomen that had gradually increased in size over the past 3 months. Initially, she did not seek medical attention because she did not ...
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Seth Sweetser,
Lewis R. Roberts,
Fabiola Medeiros
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Discussion
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pages e6-e7
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Colonic Opacification in a Patient With End-Stage Kidney Disease
06 August 2010
Question: A 66-year-old woman with end-stage chronic kidney disease undergoing peritoneal dialysis for several years presented to the emergency department with diffuse abdominal pain. Physical examina...
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Ulrich Hofmann,
Meinrad Beer
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Discussion
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pages e8-e9
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Vomiting and Painful Abdomen in Dementia
06 August 2010
Question: A 47-year-old man with a known history of dementia was admitted to our emergency department because of nausea and vomiting. Communication with the patient was impossible owing to his mental ...
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Alexey Surov,
Frank Mannes,
Curd Behrmann
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Discussion
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pages e10-e11
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| Imaging and Advanced Technology |
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Article Title |
Author(s) |
Type |
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Biomarker and Drug Discovery for Gastroenterology Through Translational Bioinformatics
20 July 2010
Mandates from federal funding agencies to refocus research toward translational medicine and heightened expectations of patients have put substantial pressure on clinicians to serve active and critica...
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Joel T. Dudley,
Atul J. Butte
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Full-length article
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pages 735-741.e1
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| Reviews in Basic and Clinical Gastroenterology and Hepatology |
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Author(s) |
Type |
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Role of Somatostatins in Gastroenteropancreatic Neuroendocrine Tumor Development and Therapy
15 July 2010
The incidence and prevalence of gastroenteropancreatic neuroendocrine tumors (GEP-NETs) have increased in the past 20 years. GEP-NETs are heterogeneous tumors, in terms of clinical and biological feat...
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Kjell E. Öberg,
Jean–Claude Reubi,
Dik J. Kwekkeboom,
Eric P. Krenning
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Review article
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pages 742-753.e1
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| Clinical-Alimentary Tract |
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Article Title |
Author(s) |
Type |
Pages |
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Acoustic Cough—Reflux Associations in Chronic Cough: Potential Triggers and Mechanisms
21 June 2010
Background & Aims: Central sensitization is thought to play a role in chronic cough and might explain the temporal association between cough and gastroesophageal reflux (GOR) in patients in whom n...
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Jaclyn A. Smith,
Samantha Decalmer,
Angela Kelsall,
Kevin McGuinness,
Helen Jones,
Simon Galloway,
Ashley Woodcock,
Lesley A. Houghton
et al.
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Full-length article
 
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pages 754-762
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Morbidity and Mortality Among Older Individuals With Undiagnosed Celiac Disease
31 May 2010
Background & Aims: Outcomes of undiagnosed celiac disease (CD) are unclear. We evaluated the morbidity and mortality of undiagnosed CD in a population-based sample of individuals 50 years of age a...
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Jonathan D. Godfrey,
Tricia L. Brantner,
Waleed Brinjikji,
Kevin N. Christensen,
Deanna L. Brogan,
Carol T. Van Dyke,
Brian D. Lahr,
Joseph J. Larson,
Alberto Rubio–Tapia,
L. Joseph Melton,
Alan R. Zinsmeister,
Robert A. Kyle,
Joseph A. Murray
et al.
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Full-length article
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pages 763-769
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Reduced Expression of FOXP3 and Regulatory T-Cell Function in Severe Forms of Early-onset Autoimmune Enteropathy
09 June 2010
Background & Aims: Little is known about the pathophysiology of early onset forms of autoimmune enteropathy (AIE). AIE has been associated with mutations in FOXP3—a transcription factor that contr...
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Nicolette Moes,
Frédéric Rieux–Laucat,
Bernadette Begue,
Julien Verdier,
Bénédicte Neven,
Natacha Patey,
Troy T. Torgerson,
Capucine Picard,
Marie–Claude Stolzenberg,
Corinne Ruemmele,
Edmond Hhm Rings,
Jean–Laurent Casanova,
Hugues Piloquet,
Armand Biver,
Anne Breton,
Hans D. Ochs,
Olivier Hermine,
Alain Fischer,
Olivier Goulet,
Nadine Cerf–Bensussan,
Frank M. Ruemmele
et al.
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Full-length article
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pages 770-778
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Inflammatory Bowel Disease Is a Risk Factor for Recurrent Venous Thromboembolism
24 May 2010
Background & Aims: Patients with inflammatory bowel disease (IBD) are at increased risk of a first venous thromboembolism (VTE), yet their risk of recurrent VTE is unknown. We performed a cohort s...
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Gottfried Novacek,
Ansgar Weltermann,
Anna Sobala,
Herbert Tilg,
Wolfgang Petritsch,
Walter Reinisch,
Andreas Mayer,
Thomas Haas,
Arthur Kaser,
Thomas Feichtenschlager,
Harry Fuchssteiner,
Peter Knoflach,
Harald Vogelsang,
Wolfgang Miehsler,
Reingard Platzer,
Wolfgang Tillinger,
Bernhard Jaritz,
Alfons Schmid,
Benedikt Blaha,
Clemens Dejaco,
Sabine Eichinger
et al.
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Full-length article
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pages 779-787.e1
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Susceptibility Genetic Variants Associated With Colorectal Cancer Risk Correlate With Cancer Phenotype
02 June 2010
Background & Aims: Ten common low-penetrant genetic variants have been consistently associated with colorectal cancer (CRC) risk; little is known about the correlation between these variants and C...
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Anna Abulí,
Xavier Bessa,
Juan Ramón González,
Clara Ruiz–Ponte,
Alejandro Cáceres,
Jenifer Muñoz,
Victoria Gonzalo,
Francesc Balaguer,
Ceres Fernández–Rozadilla,
Dolors González,
Luisa de Castro,
Juan Clofent,
Luís Bujanda,
Joaquín Cubiella,
Josep Ma Reñé,
Juan Diego Morillas,
Ángel Lanas,
Joaquim Rigau,
Ana Ma García,
Mercedes Latorre,
Joan Saló,
Fernando Fernández Bañares,
Lídia Argüello,
Elena Peña,
Àngels Vilella,
Sabino Riestra,
Ramiro Carreño,
Artemio Paya,
Cristina Alenda,
Rosa M. Xicola,
Brian J. Doyle,
Rodrigo Jover,
Xavier Llor,
Angel Carracedo,
Antoni Castells,
Sergi Castellví–Bel,
Montserrat Andreu,
Gastrointestinal Oncology Group of the Spanish Gastroenterological Association
et al.
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Full-length article
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pages 788-796.e6
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Levels of Rectal Mucosal Polyamines and Prostaglandin E2 Predict Ability of DFMO and Sulindac to Prevent Colorectal Adenoma
09 June 2010
Background & Aims: Combination of polyamine and prostaglandin E2 (PGE2)–synthesis inhibitors reduced the risk of colorectal adenoma (CRA) by 70% in patients who received polypectomies. We studied ...
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Patricia A. Thompson,
Betsy C. Wertheim,
Jason A. Zell,
Wen-Pin Chen,
Christine E. McLaren,
Bonnie J. LaFleur,
Frank L. Meyskens,
Eugene W. Gerner
et al.
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Full-length article
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pages 797-805.e1
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Preoperative Colorectal Neoplasia Increases Risk for Pouch Neoplasia in Patients With Restorative Proctocolectomy
09 June 2010
Background & Aims: Restorative proctocolectomy with ileal pouch-anal anastomosis (IPAA) has substantially reduced the risk for ulcerative colitis (UC)–associated dysplasia or cancer (neoplasia). W...
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Revital Kariv,
Feza H. Remzi,
Lei Lian,
Ana E. Bennett,
Ravi P. Kiran,
Yehuda Kariv,
Victor W. Fazio,
Ian C. Lavery,
Bo Shen
et al.
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Full-length article
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pages 806-812.e2
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| Clinical Advances in Liver, Pancreas, and Biliary Tract |
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Article Title |
Author(s) |
Type |
Pages |
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Organ Failure and Infection of Pancreatic Necrosis as Determinants of Mortality in Patients With Acute Pancreatitis
10 June 2010
Background & Aims: There is no consistency between the individual studies in the literature on whether organ failure (OF) or infected pancreatic necrosis (IPN) is the main determinant of severity ...
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Maxim S. Petrov,
Satyanarayan Shanbhag,
Mandira Chakraborty,
Anthony R.J. Phillips,
John A. Windsor
et al.
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Full-length article
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pages 813-820
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An IL28B Polymorphism Determines Treatment Response of Hepatitis C Virus Genotype 2 or 3 Patients Who Do Not Achieve a Rapid Virologic Response
04 June 2010
Background & Aims: Polymorphisms in the region of the interleukin (IL)-28B gene on chromosome 19 have been associated with peginterferon-alfa–induced clearance of genotype 1 hepatitis C virus (HCV...
|
Alessandra Mangia,
Alexander J. Thompson,
Rosanna Santoro,
Valeria Piazzolla,
Hans L. Tillmann,
Keyur Patel,
Kevin V. Shianna,
Leonardo Mottola,
Daniela Petruzzellis,
Donato Bacca,
Vito Carretta,
Nicola Minerva,
David B. Goldstein,
John G. McHutchison
et al.
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Full-length article
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pages 821-827.e1
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| Clinical-Liver, Pancreas, and Biliary Tract |
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Article Title |
Author(s) |
Type |
Pages |
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Keratin Variants Predispose to Acute Liver Failure and Adverse Outcome: Race and Ethnic Associations
09 June 2010
Background & Aims: Keratins 8 and 18 (K8/K18) provide anti-apoptotic functions upon liver injury. The cytoprotective function of keratins explains the overrepresentation of K8/K18 variants in pati...
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Pavel Strnad,
Qin Zhou,
Shinichiro Hanada,
Laura C. Lazzeroni,
Bi Hui Zhong,
Phillip So,
Timothy J. Davern,
William M. Lee,
Acute Liver Failure Study Group (ALFSG),
M. Bishr Omary
et al.
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Full-length article
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pages 828-835.e3
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Genetic Covariance Between γ-Glutamyl Transpeptidase and Fatty Liver Risk Factors: Role of β2-Adrenergic Receptor Genetic Variation in Twins
10 June 2010
Background & Aims: Plasma levels of γ-glutamyl transpeptidase (GGT) are associated with risk factors for nonalcoholic fatty liver disease (NAFLD), such as dyslipidemia, insulin resistance (IR), an...
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Rohit Loomba,
Fangwen Rao,
Lian Zhang,
Srikrishna Khandrika,
Michael G. Ziegler,
David A. Brenner,
Daniel T. O'Connor
et al.
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Full-length article
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pages 836-845.e1
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Fatty Acid Metabolism in the Liver, Measured by Positron Emission Tomography, Is Increased in Obese Individuals
31 May 2010
Background & Aims: Hepatic lipotoxicity results from and contributes to obesity-related disorders. It is a challenge to study human metabolism of fatty acids (FAs) in the liver. We combined 11C-pa...
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Patricia Iozzo,
Marco Bucci,
Anne Roivainen,
Kjell Någren,
Mikko J. Järvisalo,
Jan Kiss,
Letizia Guiducci,
Barbara Fielding,
Alexandru G. Naum,
Ronald Borra,
Kirsi Virtanen,
Timo Savunen,
Piero A. Salvadori,
Ele Ferrannini,
Juhani Knuuti,
Pirjo Nuutila
et al.
|
Full-length article
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pages 846-856.e6
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| Basic-Alimentary Tract |
| |
Article Title |
Author(s) |
Type |
Pages |
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Glucagon-Like Peptide-2 Receptor Modulates Islet Adaptation to Metabolic Stress in the ob/ob Mouse
24 May 2010
Background & Aims: Glucagon-like peptide-2 (GLP-2) is a gut hormone that increases gut growth, reduces mucosal cell death, and augments mesenteric blood flow and nutrient absorption. Exogenous GLP...
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Jasmine Bahrami,
Christine Longuet,
Laurie L. Baggio,
Karen Li,
Daniel J. Drucker
et al.
|
Full-length article
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pages 857-868
|
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Phosphoinositide 3-Kinase Signaling Mediates β-Catenin Activation in Intestinal Epithelial Stem and Progenitor Cells in Colitis
24 May 2010
Background & Aims: Mechanisms responsible for crypt architectural distortion in chronic ulcerative colitis (CUC) are not well understood. Data indicate that serine/threonine protein kinase Akt (Ak...
|
Goo Lee,
Tatiana Goretsky,
Elizabeth Managlia,
Ramanarao Dirisina,
Ajay Pal Singh,
Jeffrey B. Brown,
Randal May,
Guang–Yu Yang,
Josette William Ragheb,
B. Mark Evers,
Christopher R. Weber,
Jerrold R. Turner,
Xi C. He,
Rebecca B. Katzman,
Linheng Li,
Terrence A. Barrett
et al.
|
Full-length article
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pages 869-881.e9
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Imbalance of NKp44+NKp46− and NKp44−NKp46+ Natural Killer Cells in the Intestinal Mucosa of Patients With Crohn's Disease
31 May 2010
Background & Aims: Mucosal natural killer (NK) cells that produce interleukin (IL)-22 mediate intestinal homeostasis and inflammation in mice. However, their role in the pathogenesis of human infl...
|
Tetsuro Takayama,
Nobuhiko Kamada,
Hiroshi Chinen,
Susumu Okamoto,
Mina T. Kitazume,
Jonathan Chang,
Yumi Matuzaki,
Sadafumi Suzuki,
Akira Sugita,
Kazutaka Koganei,
Tadakazu Hisamatsu,
Takanori Kanai,
Toshifumi Hibi
et al.
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Full-length article
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pages 882-892.e3
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Indian Hedgehog Regulates Intestinal Stem Cell Fate Through Epithelial−Mesenchymal Interactions During Development
14 June 2010
Background & Aims: Intestinal stem cells (ISCs) are regulated by the mesenchymal environment via physical interaction and diffusible factors. We examined the role of Indian hedgehog (Ihh) in mesen...
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Cynthia Kosinski,
Daniel E. Stange,
Chuanrui Xu,
Annie Sy Chan,
Coral Ho,
Siu Tsan Yuen,
Randy C. Mifflin,
Don W. Powell,
Hans Clevers,
Suet Yi Leung,
Xin Chen
et al.
|
Full-length article
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pages 893-903
|
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Nucleotide-Binding Oligomerization Domain-2 Inhibits Toll-Like Receptor-4 Signaling in the Intestinal Epithelium
24 May 2010
Background & Aims: Factors that regulate enterocyte apoptosis in necrotizing enterocolitis (NEC) remain incompletely understood, although Toll-like receptor-4 (TLR4) signaling in enterocytes plays...
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Ward M. Richardson,
Chhinder P. Sodhi,
Anthony Russo,
Richard H. Siggers,
Amin Afrazi,
Steven C. Gribar,
Matthew D. Neal,
Shipan Dai,
Thomas Prindle,
Maria Branca,
Congrong Ma,
John Ozolek,
David J. Hackam
et al.
|
Full-length article
|
pages 904-917.e6
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Atonal Homolog 1 Is Required for Growth and Differentiation Effects of Notch/γ-Secretase Inhibitors on Normal and Cancerous Intestinal Epithelial Cells
02 June 2010
Background & Aims: The atonal homolog 1 (Atoh1) transcription factor is required for intestinal secretory (goblet, Paneth, enteroendocrine) cell differentiation. Notch/γ-secretase inhibitors (GSIs...
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Avedis Kazanjian,
Taeko Noah,
Douglas Brown,
Jarred Burkart,
Noah F. Shroyer
et al.
|
Full-length article
|
pages 918-928.e6
|
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F-box and WD Repeat Domain-Containing 7 Regulates Intestinal Cell Lineage Commitment and Is a Haploinsufficient Tumor Suppressor
04 June 2010
Background & Aims: The E3 ubiquitin ligase F-box and WD repeat domain-containing 7 (Fbw7) degrades several proto-oncogenes including c-Myc, cyclinE, Notch1, and c-Jun. Fbw7 is the fourth most freq...
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Rocio Sancho,
Anett Jandke,
Hayley Davis,
Markus E. Diefenbacher,
Ian Tomlinson,
Axel Behrens
et al.
|
Full-length article
|
pages 929-941
|
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Kitlow Stem Cells Cause Resistance to Kit/Platelet-Derived Growth Factor α Inhibitors in Murine Gastrointestinal Stromal Tumors
04 June 2010
Background & Aims: Gastrointestinal stromal tumors (GIST) are related to interstitial cells of Cajal (ICC) and often contain activating stem cell factor receptor (Kit) or platelet-derived growth f...
|
Michael R. Bardsley,
Viktor J. Horváth,
David T. Asuzu,
Andrea Lorincz,
Doug Redelman,
Yujiro Hayashi,
Laura N. Popko,
David L. Young,
Gwen A. Lomberk,
Raul A. Urrutia,
Gianrico Farrugia,
Brian P. Rubin,
Tamas Ordog
et al.
|
Full-length article
|
pages 942-952
|
| Basic-Liver, Pancreas, and Biliary Tract |
| |
Article Title |
Author(s) |
Type |
Pages |
|
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Monoclonal Anti-Claudin 1 Antibodies Prevent Hepatitis C Virus Infection of Primary Human Hepatocytes
02 June 2010
Background & Aims: Hepatitis C virus (HCV) infection is a challenge to prevent and treat because of the rapid development of drug resistance and escape. Viral entry is required for initiation, spr...
|
Isabel Fofana,
Sophie E. Krieger,
Fritz Grunert,
Sandra Glauben,
Fei Xiao,
Samira Fafi–Kremer,
Eric Soulier,
Cathy Royer,
Christine Thumann,
Christopher J. Mee,
Jane A. McKeating,
Tatjana Dragic,
Patrick Pessaux,
Francoise Stoll–Keller,
Catherine Schuster,
John Thompson,
Thomas F. Baumert
et al.
|
Full-length article
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pages 953-964.e4
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Meta-Analysis of Hepatitis C Virus Vaccine Efficacy in Chimpanzees Indicates an Importance for Structural Proteins
04 June 2010
Background & Aims: Studies in patients and chimpanzees that spontaneously cleared hepatitis C virus (HCV) infections demonstrated that natural immunity to the virus is induced during primary infec...
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Harel Dahari,
Stephen M. Feinstone,
Marian E. Major
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Full-length article
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pages 965-974
|
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Effects and Regulation of Autoreactive CD8+ T Cells in a Transgenic Mouse Model of Autoimmune Hepatitis
02 June 2010
Background & Aims: Autoimmune hepatitis (AIH) is a chronic inflammatory liver disease of unknown etiology. Autoreactive T cells are thought to mediate liver injury, but the pathogenesis of AIH is ...
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Mario Zierden,
Elisabeth Kühnen,
Margarete Odenthal,
Hans-Peter Dienes
|
Full-length article
|
pages 975-986.e3
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Genetic Labeling Does Not Detect Epithelial-to-Mesenchymal Transition of Cholangiocytes in Liver Fibrosis in Mice
24 May 2010
Background & Aims: Chronic injury changes the fate of certain cellular populations, inducing epithelial cells to generate fibroblasts by epithelial-to-mesenchymal transition (EMT) and mesenchymal ...
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David Scholten,
Christoph H. Österreicher,
Anjali Scholten,
Keiko Iwaisako,
Guoqiang Gu,
David A. Brenner,
Tatiana Kisseleva
et al.
|
Full-length article
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pages 987-998
|
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Lentiviral Vectors That Express UGT1A1 in Liver and Contain miR-142 Target Sequences Normalize Hyperbilirubinemia in Gunn Rats
24 May 2010
Background & Aims: Crigler–Najjar type 1 (CN-I) is an inherited liver disease caused by an absence of bilirubin–uridine 5′-diphosphate–glucuronosyltransferase (UGT1A1) activity. It results in life...
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Françoise Schmitt,
Séverine Remy,
Anne Dariel,
Maude Flageul,
Virginie Pichard,
Sébastien Boni,
Claire Usal,
Anne Myara,
Sophie Laplanche,
Ignacio Anegon,
Philippe Labrune,
Guillaume Podevin,
Nicolas Ferry,
Tuan Huy Nguyen
et al.
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Full-length article
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pages 999-1007.e2
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Lysophosphatidic Acid Is a Potential Mediator of Cholestatic Pruritus
24 May 2010
Background & Aims: Pruritus is a common and disabling symptom in cholestatic disorders. However, its causes remain unknown. We hypothesized that potential pruritogens accumulate in the circulation...
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Andreas E. Kremer,
Job J.W.W. Martens,
Wim Kulik,
Franziska Ruëff,
Edith M.M. Kuiper,
Henk R. van Buuren,
Karel J. van Erpecum,
Jurate Kondrackiene,
Jesus Prieto,
Christian Rust,
Victoria L. Geenes,
Catherine Williamson,
Wouter H. Moolenaar,
Ulrich Beuers,
Ronald P.J. Oude Elferink
et al.
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Full-length article
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pages 1008-1018.e1
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Therapeutic Liver Reconstitution With Murine Cells Isolated Long After Death
04 June 2010
Background & Aims: Due to the shortage of donor organs, many patients needing liver transplantation cannot receive one. For some liver diseases, hepatocyte transplantation could be a viable altern...
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Laura Erker,
Hisaya Azuma,
Andrew Y. Lee,
Changsheng Guo,
Susan Orloff,
Laura Eaton,
Eric Benedetti,
Bryan Jensen,
Milton Finegold,
Holger Willenbring,
Markus Grompe
et al.
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Full-length article
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pages 1019-1029
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CD39/ENTPD1 Expression by CD4+Foxp3+ Regulatory T Cells Promotes Hepatic Metastatic Tumor Growth in Mice
24 May 2010
Background & Aims: Adenosine mediates immune suppression and is generated by the ectonucleotidases CD39 (ENTPD1) and CD73 that are expressed on vascular endothelial cells and regulatory T cells (T...
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Xiaofeng Sun,
Yan Wu,
Wenda Gao,
Keiichi Enjyoji,
Eva Csizmadia,
Christa E. Müller,
Takashi Murakami,
Simon C. Robson
et al.
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Full-length article
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pages 1030-1040
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CD10+ Pancreatic Stellate Cells Enhance the Progression of Pancreatic Cancer
07 June 2010
Background & Aims: Pancreatic stellate cells (PSCs) promote the progression of pancreatic cancer by producing extracellular matrix and soluble factors. However, the functional heterogeneity of PSC...
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Naoki Ikenaga,
Kenoki Ohuchida,
Kazuhiro Mizumoto,
Lin Cui,
Tadashi Kayashima,
Katsuya Morimatsu,
Taiki Moriyama,
Kohei Nakata,
Hayato Fujita,
Masao Tanaka
et al.
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Full-length article
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pages 1041-1051.e8
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| Continuing Medical Education (CME) Activities |
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Article Title |
Author(s) |
Type |
Pages |
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Continuing Medical Education Exam 1: Inflammatory Bowel Disease Is a Risk Factor for Recurrent Venous Thromboembolism
23 July 2010
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Examination
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pages e12-e13
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Continuing Medical Education Exam 2: Organ Failure and Infection of Pancreatic Necrosis as Determinants of Mortality in Patients With Acute Pancreatitis
23 July 2010
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Examination
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page e13
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| AGA |
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Author(s) |
Type |
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Report of the AGA Institute Education and Training Committee Task Force on Physician Reentry
The Council on Medical Education of the American Medical Association (AMA) has requested a study of the issue of physician reentry into clinical practice, in collaboration with the respective specialt...
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Arthur J. Decross,
Darrell S. Pardi,
Deborah D. Proctor
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Full-length article
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pages e17-e26
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| Selected Summaries |
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Author(s) |
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Transferrin Receptor 1: A Ferritin Receptor as Well?
06 August 2010
Li L, Fang CJ, Ryan JC, et al. (Department of Medicine, Veterans Administration Medical Center, San Francisco, CA; others). Binding and uptake of H-ferritin are mediated by human transferrin receptor-...
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Daniel F. Wallace,
Cameron McDonald,
V. Nathan Subramaniam
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Discussion
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pages 1052-1053
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Probiotics for Ulcerative Colitis … Are The Good Bugs Back?
06 August 2010
Sood A, Midha V, Makharia, GK, et al. (Department of Gastroenterology and Medicine, Dayanad Medical College and Hospital, Ludhiana, India; Department of Gastroenterology and Human Nutrition, All India...
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Shamita B. Shah
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Discussion
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pages 1054-1056
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Reply
26 July 2010
We thank Dr Shah for her appreciation of our study and acceptance of our results. We agree that further, well-designed, randomized, controlled trials are needed to confirm our results. A recent study ...
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Ajit Sood,
Vandana Midha,
Govind K. Makharia,
Vineet Ahuja,
Dinesh Singal,
Pooja Goswami,
Rakesh K. Tandon
et al.
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Discussion
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page 1056
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Is Lack of “Education” a Mechanism Driving Loss of Tolerance in Crohn's Disease?
05 August 2010
Iliev ID, Spadoni I, Mileti E, et al. (Department of Experimental Oncology, European Institute of Oncology, Milan, Italy). Human intestinal epithelial cells promote the differentiation of tolerogenic ...
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Marisol Veny,
Azucena Salas,
Julian Panes
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Discussion
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pages 1056-1058
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Reply
26 July 2010
Doctors Veny, Salas, and Panes correctly point out that in our reports (Gut 2009;58:1481–1489; Nat Immunol 2005;6:507–514) we have isolated epithelial cells from regions that were not macroscopically ...
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Maria Rescigno,
Iliyan D. Iliev
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Discussion
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pages 1058-1059
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Infliximab and Azathioprine for Crohn's Disease: A Super-Sonic Combination?
26 July 2010
Colombel JF, Sandborn WJ, Reinisch W, et al; SONIC Study Group. (Hôpital Claude Huriez and Centre d'Investigation Clinique, Centre Hospitalier Universitaire de Lille, Université Lille Nord de France, ...
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Laurent Peyrin–Biroulet,
Silvio Danese
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Discussion
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pages 1059-1061
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