EASL International Consensus Conference on Haemochromatosis: Part II. Expert Document☆☆☆
The precise frequency of the different iron overload states due to haemochromatosis (HC) is unknown and need to be addressed in population studies . The appropriate terminology for different iron overload states along the continuum is given below. The expert panel considers it both appropriate and feasible to define an over-accumulation state distinct from haemochromatosis. “Excess body iron storage” (iron overload) [haemosiderosis=iron staining in tissues] may be: i) Minimal: ∼1.5g (hepatic iron concentration, HIC, >30 μM/g) (?pathological significance: e.g. porphyria cutanea tarda (PCT); ii) Modest: 2–5 g (HIC>100 μM/g; serum ferritin approx 500 μg/l) (seen in chronic liver disease, haemolytic disorders, PCT, etc.); iii) Severe: >5 g (HIC >200 μM/g; serum ferritin approx 750 μg/l).
1University of Western Ontario, London, Ontario, Canada
2Clinique des Maladies du Foie et Unité INSERM U-522 Hôpital Pontchaillou, Rennes, France
3Queensland Institute of Medical Research, 300 Herston Road, Brisbane, Queensland4029 Australia
☆ Co-sponsored by the World Health Organization∗ Supported by the National Institutes of Health and the Centers for Disease Control and Prevention (USA)
☆☆ This document summarises the discussion and the conclusions reached by the three different expert groups1 engaged in the consensus conference
* The views expressed in the jury document are not necessarily those of the WHO Secretariat.
1Expert groups: A: Nomenclature/Classification: Lawrie W. Powell (Australia) (Co-ordinator), Tom Bothwell (South Africa), Gary Britthenam (USA), Clara Camaschella (Italy), Elen Clayton (USA), James Cook (USA), Maria De Sousa (Portugal), Yves Deugnier (France), Gemino Fiorelli (Italy), Norman Grace (USA), Anthony Tavill (USA) B: Natural History, Diagnostic and Therapeutic Aspects: Pierre Brissot (France) (Co-ordinator), Bruce R. Bacon (USA), Herbert L. Bonkovsky (USA), Dario Conte (Italy), Darrel Crawford (Australia), James Dooley (UK), Silvia Fargion (Italy), Rolf Hultcrantz (Sweden), Jo JM Marx (The Netherlands); Population Screening: Paul Adams (Canada) (Co-ordinator), James Barton (USA), Linda A. Bradley (USA), Wylie Burke (USA), John Crowe (Ireland), James Kushner (USA), Sigvard Olsson (Sweden), Pradyumna Phatak (USA), Alberto Piperno (Italy), Graca Porto (Portugal), Mark Worwood (UK).
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