Gastroenterology
Volume 142, Issue 2 , Pages 292-304 , February 2012

Deficiency of Claudin-18 Causes Paracellular H+ Leakage, Up-regulation of Interleukin-1β, and Atrophic Gastritis in Mice

  • Daisuke Hayashi

      Affiliations

    • Laboratory of Biological Science, Graduate School of Frontier Biosciences and Graduate School of Medicine, Osaka University, Osaka, Japan
    • Department of Geriatric Medicine and Nephrology, Graduate School of Medicine, Osaka University, Osaka, Japan
    • ,
  • Atsushi Tamura

      Affiliations

    • Laboratory of Biological Science, Graduate School of Frontier Biosciences and Graduate School of Medicine, Osaka University, Osaka, Japan
    • ,
  • Hiroo Tanaka

      Affiliations

    • Laboratory of Biological Science, Graduate School of Frontier Biosciences and Graduate School of Medicine, Osaka University, Osaka, Japan
    • ,
  • Yuji Yamazaki

      Affiliations

    • Laboratory of Biological Science, Graduate School of Frontier Biosciences and Graduate School of Medicine, Osaka University, Osaka, Japan
    • ,
  • Shin Watanabe

      Affiliations

    • Laboratory of Biological Science, Graduate School of Frontier Biosciences and Graduate School of Medicine, Osaka University, Osaka, Japan
    • ,
  • Koya Suzuki

      Affiliations

    • Laboratory of Biological Science, Graduate School of Frontier Biosciences and Graduate School of Medicine, Osaka University, Osaka, Japan
    • ,
  • Kazuo Suzuki

      Affiliations

    • Department of Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan
    • ,
  • Kazuhiro Sentani

      Affiliations

    • Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    • ,
  • Wataru Yasui

      Affiliations

    • Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    • ,
  • Hiromi Rakugi

      Affiliations

    • Department of Geriatric Medicine and Nephrology, Graduate School of Medicine, Osaka University, Osaka, Japan
    • ,
  • Yoshitaka Isaka

      Affiliations

    • Department of Geriatric Medicine and Nephrology, Graduate School of Medicine, Osaka University, Osaka, Japan
    • ,
  • Sachiko Tsukita

      Affiliations

    • Laboratory of Biological Science, Graduate School of Frontier Biosciences and Graduate School of Medicine, Osaka University, Osaka, Japan
    • Corresponding Author InformationReprint requests Address requests for reprints to: Sachiko Tsukita, PhD, Laboratory of Biological Science, Graduate School of Frontier Biosciences, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan. fax: (81) 6-6879-3329

Received 28 June 2011 ,Accepted 26 October 2011.

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 Conflicts of interest The authors disclose no conflicts.

 Funding Supported in part by a Grant-in-Aid for Creative Scientific Research from the Ministry of Education, Science and Culture of Japan (to S.T.).

PII: S0016-5085(11)01517-4

doi: 10.1053/j.gastro.2011.10.040

Gastroenterology
Volume 142, Issue 2 , Pages 292-304 , February 2012

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