Gastroenterology
Volume 142, Issue 2 , Pages 248-256 , February 2012

Next-Generation Stool DNA Test Accurately Detects Colorectal Cancer and Large Adenomas

  • David A. Ahlquist

      Affiliations

    • Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota
    • Corresponding Author InformationReprint requests Address requests for reprints to: David A. Ahlquist, MD, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota 55905. fax: (507) 266-0350
    • ,
  • Hongzhi Zou

      Affiliations

    • Exact Sciences Corporation, Madison, Wisconsin
    • ,
  • Michael Domanico

      Affiliations

    • Exact Sciences Corporation, Madison, Wisconsin
    • ,
  • Douglas W. Mahoney

      Affiliations

    • Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota
    • ,
  • Tracy C. Yab

      Affiliations

    • Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota
    • ,
  • William R. Taylor

      Affiliations

    • Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota
    • ,
  • Malinda L. Butz

      Affiliations

    • Division of Molecular Genetics, Mayo Clinic, Rochester, Minnesota
    • ,
  • Stephen N. Thibodeau

      Affiliations

    • Division of Molecular Genetics, Mayo Clinic, Rochester, Minnesota
    • ,
  • Linda Rabeneck

      Affiliations

    • Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    • ,
  • Lawrence F. Paszat

      Affiliations

    • Dalla Lana School of Public Health, Toronto, Ontario, Canada
    • ,
  • Kenneth W. Kinzler

      Affiliations

    • The Ludwig Center and Howard Hughes Medical Institute at Johns Hopkins, Johns Hopkins Medical Center, Baltimore, Maryland
    • ,
  • Bert Vogelstein

      Affiliations

    • The Ludwig Center and Howard Hughes Medical Institute at Johns Hopkins, Johns Hopkins Medical Center, Baltimore, Maryland
    • ,
  • Niels Chr. Bjerregaard

      Affiliations

    • The Ludwig Center and Howard Hughes Medical Institute at Johns Hopkins, Johns Hopkins Medical Center, Baltimore, Maryland
    • ,
  • Søren Laurberg

      Affiliations

    • Department of Surgery, Aarhus University Hospital, Aarhus, Denmark
    • ,
  • Henrik Toft Sørensen

      Affiliations

    • Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark
    • ,
  • Barry M. Berger

      Affiliations

    • Exact Sciences Corporation, Madison, Wisconsin
    • ,
  • Graham P. Lidgard

      Affiliations

    • Exact Sciences Corporation, Madison, Wisconsin

Received 31 May 2011 ,Accepted 24 October 2011.

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 This article has an accompanying continuing medical education activity on page e25. Learning Objective: Upon completion of this CME activity, successful learners will be able to appraise the early clinical performance of a next-generation stool DNA test for detection of colorectal cancer and large adenomas.

 Conflicts of interest These authors disclose the following: Dr Ahlquist and Mr Taylor are inventors of licensed technology. Drs Ahlquist and Vogelstein are scientific advisors to Exact Sciences. Drs Zou, Domanico, Berger, and Lidgard are employees of Exact Sciences. Mayo Clinic has licensed intellectual property to and is a minor equity investor in Exact Sciences. The remaining authors disclose no conflicts.

 Funding Exact Sciences Corporation, National Institutes of Health grant CA 62924, and grants from Charles Oswald Foundation and Virginia and D.K. Ludwig Fund for Cancer Research.

PII: S0016-5085(11)01505-8

doi: 10.1053/j.gastro.2011.10.031

Gastroenterology
Volume 142, Issue 2 , Pages 248-256 , February 2012

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