Digesting New Information About the Role of Trypsin in Pancreatitis

A comparison of models depicting the role of trypsin in acute pancreatitis. In the original “trypsin paradigm,” the activation of trypsin was the 1 key mechanism upon which all of the aspects of pancreatitis followed. In the newer “multifaceted paradigm,” trypsin activity is 1 of several interrelated mechanisms that is simultaneously activated when acinar cells are injured. With the multifaceted model, different mechanisms can be more affected by specific causal factors and, therefore, can explain observed differences in pancreatitis initiated by different etiologies.