Gastroenterology
Volume 142, Issue 1 , Pages 140-151.e12 , January 2012

Alterations in Lipid Metabolism Mediate Inflammation, Fibrosis, and Proliferation in a Mouse Model of Chronic Cholestatic Liver Injury

  • Tarek Moustafa

      Affiliations

    • Laboratory of Experimental and Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, Graz, Austria
    • Hans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria
    • ,
  • Peter Fickert

      Affiliations

    • Laboratory of Experimental and Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, Graz, Austria
    • ,
  • Christoph Magnes

      Affiliations

    • HEALTH - Institute for Biomedicine and Health Sciences, Joanneum Research, Graz, Austria
    • ,
  • Christian Guelly

      Affiliations

    • Center for Medical Research, Medical University of Graz, Graz, Austria
    • ,
  • Andrea Thueringer

      Affiliations

    • Institute of Pathology, Medical University of Graz, Graz, Austria
    • ,
  • Sasa Frank

      Affiliations

    • Institute of Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria
    • ,
  • Dagmar Kratky

      Affiliations

    • Institute of Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria
    • ,
  • Wolfgang Sattler

      Affiliations

    • Institute of Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria
    • ,
  • Helga Reicher

      Affiliations

    • Institute of Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria
    • ,
  • Frank Sinner

      Affiliations

    • HEALTH - Institute for Biomedicine and Health Sciences, Joanneum Research, Graz, Austria
    • ,
  • Judith Gumhold

      Affiliations

    • Laboratory of Experimental and Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, Graz, Austria
    • ,
  • Dagmar Silbert

      Affiliations

    • Laboratory of Experimental and Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, Graz, Austria
    • ,
  • Günter Fauler

      Affiliations

    • Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria
    • ,
  • Gerald Höfler

      Affiliations

    • Institute of Pathology, Medical University of Graz, Graz, Austria
    • ,
  • Achim Lass

      Affiliations

    • Institute of Molecular Biosciences, University of Graz, Graz, Austria
    • ,
  • Rudolf Zechner

      Affiliations

    • Institute of Molecular Biosciences, University of Graz, Graz, Austria
    • ,
  • Michael Trauner

      Affiliations

    • Laboratory of Experimental and Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, Graz, Austria
    • Hans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria
    • Corresponding Author InformationReprint requests Address requests for reprints to: Michael Trauner, MD, Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Waehringerguertel 18-20, A-1090 Vienna, Austria

Received 31 January 2011 ,Accepted 29 September 2011.

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 Conflicts of interest The authors disclose the following: The Medical University Graz has filed a patent on the use of 24-norUDCA in chronic liver disease, and Michael Trauner and Peter Fickert are listed as coinventors. The remaining authors disclose no conflicts.

 Funding Supported by grants P19118 and the SFB-Lipotox F30 from the Austrian Science Fund.

PII: S0016-5085(11)01377-1

doi: 10.1053/j.gastro.2011.09.051

Gastroenterology
Volume 142, Issue 1 , Pages 140-151.e12 , January 2012

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