Gastroenterology
Volume 142, Issue 1 , Pages 152-164.e10 , January 2012

A High-Cholesterol Diet Exacerbates Liver Fibrosis in Mice via Accumulation of Free Cholesterol in Hepatic Stellate Cells

  • Toshiaki Teratani

      Affiliations

    • Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    • ,
  • Kengo Tomita

      Affiliations

    • Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    • Division of Gastroenterology and Hepatology, Department of Internal Medicine, National Defense Medical College, Saitama, Japan
    • Corresponding Author InformationReprint requests Address requests for reprints to: Kengo Tomita, MD, PhD, Division of Gastroenterology and Hepatology, Department of Internal Medicine, National Defense Medical College, 3-2 Namiki, Tokorozawa-shi, Saitama 359-8513, Japan. fax: (81) 4-2996-5201
    • ,
  • Takahiro Suzuki

      Affiliations

    • Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    • ,
  • Tetsuya Oshikawa

      Affiliations

    • Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    • ,
  • Hirokazu Yokoyama

      Affiliations

    • Health Center, Keio University School of Medicine, Tokyo, Japan
    • ,
  • Katsuyoshi Shimamura

      Affiliations

    • Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    • ,
  • Susumu Tominaga

      Affiliations

    • Department of Pathology and Laboratory Medicine, National Defense Medical College, Saitama, Japan
    • ,
  • Sadayuki Hiroi

      Affiliations

    • Department of Pathology and Laboratory Medicine, National Defense Medical College, Saitama, Japan
    • ,
  • Rie Irie

      Affiliations

    • Department of Pathology, Kawasaki Municipal Hospital, Kanagawa, Japan
    • ,
  • Yoshikiyo Okada

      Affiliations

    • Division of Gastroenterology and Hepatology, Department of Internal Medicine, National Defense Medical College, Saitama, Japan
    • ,
  • Chie Kurihara

      Affiliations

    • Division of Gastroenterology and Hepatology, Department of Internal Medicine, National Defense Medical College, Saitama, Japan
    • ,
  • Hirotoshi Ebinuma

      Affiliations

    • Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    • ,
  • Hidetsugu Saito

      Affiliations

    • Graduate School of Pharmaceutical Sciences, Keio University Faculty of Pharmacy, Tokyo, Japan
    • ,
  • Ryota Hokari

      Affiliations

    • Division of Gastroenterology and Hepatology, Department of Internal Medicine, National Defense Medical College, Saitama, Japan
    • ,
  • Kazuo Sugiyama

      Affiliations

    • Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    • ,
  • Takanori Kanai

      Affiliations

    • Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    • ,
  • Soichiro Miura

      Affiliations

    • Division of Gastroenterology and Hepatology, Department of Internal Medicine, National Defense Medical College, Saitama, Japan
    • ,
  • Toshifumi Hibi

      Affiliations

    • Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan

Received 13 November 2010 ,Accepted 24 September 2011.

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 Conflicts of interest The authors disclose no conflicts.

 Funding This study was supported in part by a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology of Japan (to K. Tomita).

PII: S0016-5085(11)01375-8

doi: 10.1053/j.gastro.2011.09.049

Gastroenterology
Volume 142, Issue 1 , Pages 152-164.e10 , January 2012

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