Gastroenterology
Volume 141, Issue 3 , Pages 819-826.e1 , September 2011

Ultrasound Elasticity Imaging for Detecting Intestinal Fibrosis and Inflammation in Rats and Humans With Crohn's Disease

  • Ryan W. Stidham

      Affiliations

    • Department of Medicine, University of Michigan, Ann Arbor, Michigan
    • ,
  • Jingping Xu

      Affiliations

    • Center for Ultrasound Molecular Imaging and Therapeutics, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
    • Cardiovascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
    • ,
  • Laura A. Johnson

      Affiliations

    • Department of Medicine, University of Michigan, Ann Arbor, Michigan
    • ,
  • Kang Kim

      Affiliations

    • Center for Ultrasound Molecular Imaging and Therapeutics, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
    • Cardiovascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
    • Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania
    • ,
  • David S. Moons

      Affiliations

    • Department of Pathology, University of Michigan, Ann Arbor, Michigan
    • ,
  • Barbara J. McKenna

      Affiliations

    • Department of Pathology, University of Michigan, Ann Arbor, Michigan
    • ,
  • Jonathan M. Rubin

      Affiliations

    • Department of Radiology, University of Michigan, Ann Arbor, Michigan
    • ,
  • Peter D.R. Higgins

      Affiliations

    • Department of Medicine, University of Michigan, Ann Arbor, Michigan
    • Corresponding Author InformationReprint requests Address requests for reprints to: Peter D.R. Higgins, SPC 5682, 1150 West Medical Center Drive, Ann Arbor, Michigan 48109

References 

  1. Loftus EV, Schoenfeld P, Sandborn WJ. The epidemiology and natural history of Crohn's disease in population-based patient cohorts from North America: a systematic review. Aliment Pharmacol Ther. 2002;16:51–60
  2. Peyrin-Biroulet L, Loftus EV, Colombel JF, et al. The natural history of adult Crohn's disease in population-based cohorts. Am J Gastroenterol. 2010;105:289–297
  3. Bernstein CN, Nabalamba A. Hospitalization, surgery, and readmission rates of IBD in Canada: a population-based study. Am J Gastroenterol. 2006;101:110–118
  4. Holtmann M, Wanitschke R, Helisch A, et al. Anti-TNF antibodies in the treatment of inflammatory intestinal stenoses in Crohn's disease. Z Gastroenterol. 2003;41:11–17
  5. Lichtenstein GR, Olson A, Travers S, et al. Factors associated with the development of intestinal strictures or obstructions in patients with Crohn's disease. Am J Gastroenterol. 2006;101:1030–1038
  6. Ophir J, Cespedes I, Ponnekanti H, et al. Elastography: a quantitative method for imaging the elasticity of biological tissues. Ultrason Imaging. 1991;13:111–134
  7. O'Donnell M, Shapo BM, Emelianov SY. Internal displacement and strain imaging using ultrasonic speckle tracking. IEEE Trans Ultrason Ferroelectr Freq Control. 1994;41:314–325
  8. Rubin JM, Aglyamov SR, Wakefield TW, et al. Clinical application of sonographic elasticity imaging for aging of deep venous thrombosis: preliminary findings. J Ultrasound Med. 2003;22:443–448
  9. Rubin JM, Xie H, Kim KW, et al. Sonographic elasticity imaging of acute and chronic deep venous thrombosis in humans. J Ultrasound Med. 2006;25:1179–1186
  10. Perk G, Tunick PA, Kronzon I. Non-Doppler two-dimensional strain imaging by echocardiography: from technical considerations to clinical applications. J Am Soc Echocardiogr. 2007;20:234–243
  11. Weitzel WF, Kim K, Rubin JM, et al. Feasibility of applying ultrasound strain imaging to detect renal transplant chronic allograft nephropathy. Kidney Int. 2004;65:733–736
  12. Kim K, Johnson LA, Jia C, et al. Noninvasive ultrasound elasticity imaging (UEI) of Crohn's disease: animal model. Ultrasound Med Biol. 2008;34:902–912
  13. Morris GP, Beck PL, Herridge MS, et al. Hapten-induced model of chronic inflammation and ulceration in the rat colon. Gastroenterology. 1989;96:795–803
  14. Travis SP, Stange EF, Lemann M, et al. European evidence based consensus on the diagnosis and management of Crohn's disease: current management. Gut. 2006;55(Suppl 1):i16–i35
  15. Fraquelli M, Sarno A, Girelli C, et al. Reproducibility of bowel ultrasonography in the evaluation of Crohn's disease. Dig Liver Dis. 2008;40:860–866
  16. Camoglio L, te Velde AA, de Boer A, et al. Hapten-induced colitis associated with maintained Th1 and inflammatory responses in IFN-gamma receptor-deficient mice. Eur J Immunol. 2000;30:1486–1495
  17. te Velde AA, Verstege MI, Hommes DW. Critical appraisal of the current practice in murine TNBS-induced colitis. Inflamm Bowel Dis. 2006;12:995–999

 Conflicts of interest The authors disclose no conflicts.

 Funding Supported by grants R21-DK081123-01 (KK, JX, PDRH, JMR); K08-DK080172-01 (PDRH), and T32-DK007367-01 (RWS).

PII: S0016-5085(11)00991-7

doi: 10.1053/j.gastro.2011.07.027

Gastroenterology
Volume 141, Issue 3 , Pages 819-826.e1 , September 2011

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