Gastroenterology
Volume 141, Issue 5 , Pages 1782-1791 , November 2011

Gastrointestinal Microbiome Signatures of Pediatric Patients With Irritable Bowel Syndrome

  • Delphine M. Saulnier

      Affiliations

    • Departments of Pathology & Immunology, Baylor College of Medicine, Houston, Texas
    • Department of Pathology, Texas Children's Hospital, Houston, Texas
    • NIZO, Ede, The Netherlands
    • ,
  • Kevin Riehle

      Affiliations

    • Department of Molecular & Human Genetics, Baylor College of Medicine, Houston, Texas
    • Bioinformatics Research Laboratory, Baylor College of Medicine, Houston, Texas
    • ,
  • Toni–Ann Mistretta

      Affiliations

    • Departments of Pathology & Immunology, Baylor College of Medicine, Houston, Texas
    • Department of Pathology, Texas Children's Hospital, Houston, Texas
    • ,
  • Maria–Alejandra Diaz

      Affiliations

    • Departments of Pathology & Immunology, Baylor College of Medicine, Houston, Texas
    • Department of Pathology, Texas Children's Hospital, Houston, Texas
    • ,
  • Debasmita Mandal

      Affiliations

    • Department of Medicine, University of California San Francisco, San Francisco, California
    • ,
  • Sabeen Raza

      Affiliations

    • Departments of Pathology & Immunology, Baylor College of Medicine, Houston, Texas
    • Department of Pathology, Texas Children's Hospital, Houston, Texas
    • ,
  • Erica M. Weidler

      Affiliations

    • Department of Pediatrics, Baylor College of Medicine, Houston, Texas
    • Children's Nutrition Research Center, Houston, Texas
    • ,
  • Xiang Qin

      Affiliations

    • Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas
    • ,
  • Cristian Coarfa

      Affiliations

    • Department of Molecular & Human Genetics, Baylor College of Medicine, Houston, Texas
    • Bioinformatics Research Laboratory, Baylor College of Medicine, Houston, Texas
    • ,
  • Aleksandar Milosavljevic

      Affiliations

    • Department of Molecular & Human Genetics, Baylor College of Medicine, Houston, Texas
    • Bioinformatics Research Laboratory, Baylor College of Medicine, Houston, Texas
    • ,
  • Joseph F. Petrosino

      Affiliations

    • Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas
    • Department of Molecular Virology & Microbiology, Baylor College of Medicine, Houston, Texas
    • Center for Metagenomics and Microbiome Research, Baylor College of Medicine, Houston, Texas
    • ,
  • Sarah Highlander

      Affiliations

    • Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas
    • Department of Molecular Virology & Microbiology, Baylor College of Medicine, Houston, Texas
    • ,
  • Richard Gibbs

      Affiliations

    • Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas
    • ,
  • Susan V. Lynch

      Affiliations

    • Department of Medicine, University of California San Francisco, San Francisco, California
    • ,
  • Robert J. Shulman

      Affiliations

    • Department of Pediatrics, Baylor College of Medicine, Houston, Texas
    • Children's Nutrition Research Center, Houston, Texas
    • ,
  • James Versalovic

      Affiliations

    • Departments of Pathology & Immunology, Baylor College of Medicine, Houston, Texas
    • Department of Pathology, Texas Children's Hospital, Houston, Texas
    • Department of Molecular & Human Genetics, Baylor College of Medicine, Houston, Texas
    • Department of Pediatrics, Baylor College of Medicine, Houston, Texas
    • Department of Molecular Virology & Microbiology, Baylor College of Medicine, Houston, Texas
    • Corresponding Author InformationReprint requests Address requests for reprints to: James Versalovic, MD, PhD, Texas Children's Hospital Feigin Center, 1102 Bates Avenue, Suite 830, Feigin Center, Houston, Texas 77030. fax: (832) 825-1165

Received 21 January 2011 ,Accepted 24 June 2011.

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 Conflicts of interest The authors disclose the following: Versalovic serves on an advisory board for Danone and he receives unrestricted research support from Biogaia AB. The remaining authors disclose no conflicts.

 Funding Supported by the National Institute of Diabetes, Digestive and Kidney Diseases (NIDDK) and the National Center for Complementary and Alternative Medicine (NCCAM) from the National Institute of Health (NIH) (grant UH2 DK083990-01 and UH3 DK083990-02). The work in J.V.'s laboratory is supported by NIDDK (R01 DK065075 and P30 DK56338), NIH National Center for Complementary and Alternative Medicine (R01 AT004326 and R21 AT003102), and NHGRI (HMP sampling Jumpstart 5U54 HG003273-08, with R.G. as principal investigator). S.V.L. is supported by the Rainin Foundation.

PII: S0016-5085(11)00922-X

doi: 10.1053/j.gastro.2011.06.072

Gastroenterology
Volume 141, Issue 5 , Pages 1782-1791 , November 2011

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