Gastroenterology
Volume 141, Issue 4 , Pages 1194-1201, October 2011

Early Mucosal Healing With Infliximab Is Associated With Improved Long-term Clinical Outcomes in Ulcerative Colitis

  • Jean Frédéric Colombel

      Affiliations

    • Department of Hepatogastroenterology, CHU Lille and INSERM-CIC9301, Universite Lille Nord de France
    • Corresponding Author InformationReprint requests Address requests for reprints to: Jean Frédéric Colombel, MD, Hopital Claude Huriez, Centre Hopitalier Universitaire de Lille, Rue Michel Polonovski, Lille, France 59037. fax: (33) 3-20-44-47-13
    • ,
  • Paul Rutgeerts

      Affiliations

    • Department of Gastroenterology, University Hospital Gasthuisberg, Leuven, Belgium
    • ,
  • Walter Reinisch

      Affiliations

    • Department of Gastroenterology and Hepatology, Universität Klinik für Innere Medizin III, AKH Wien, Vienna, Austria
    • ,
  • Dirk Esser

      Affiliations

    • Janssen Biologics, BV, Leiden, The Netherlands
    • ,
  • Yanxin Wang

      Affiliations

    • Schering Corporation, Subsidiary of Merck & Co, Inc, Kenilworth, New Jersey
    • ,
  • Yinghua Lang

      Affiliations

    • Department of Biostatistics, Centocor Research & Development, a division of Johnson & Johnson Pharmaceutical Research & Development, LLC, Malvern, Pennsylvania
    • ,
  • Colleen W. Marano

      Affiliations

    • Department of Immunology, Centocor Research & Development, a division of Johnson & Johnson Pharmaceutical Research & Development, LLC, Malvern, Pennsylvania
    • ,
  • Richard Strauss

      Affiliations

    • Department of Immunology, Centocor Research & Development, a division of Johnson & Johnson Pharmaceutical Research & Development, LLC, Malvern, Pennsylvania
    • ,
  • Björn J. Oddens

      Affiliations

    • Schering Corporation, Subsidiary of Merck & Co, Inc, Kenilworth, New Jersey
    • ,
  • Brian G. Feagan

      Affiliations

    • Robarts Research Institute, University of Western Ontario, London, Ontario, Canada
    • ,
  • Stephen B. Hanauer

      Affiliations

    • University of Chicago, Chicago, Illinois
    • ,
  • Gary R. Lichtenstein

      Affiliations

    • University of Pennsylvania, Philadelphia, Pennsylvania
    • ,
  • Daniel Present

      Affiliations

    • Mount Sinai Medical Center, New York, New York
    • ,
  • Bruce E. Sands

      Affiliations

    • Mount Sinai Medical Center, New York, New York
    • ,
  • William J. Sandborn

      Affiliations

    • University of California San Diego, La Jolla, California

Received 22 December 2010; accepted 17 June 2011. published online 01 July 2011.

To access this article, please choose from the options below

Login to an existing account or Register a new account.

  • Purchase this article for 30.00 USD (You must login/register to purchase this article)

    Online access for 24 hours. The PDF version can be downloaded as your permanent record.

  • Subscribe to this title

    Get unlimited online access to this article and all other articles in this title 24/7 for one year.

  • Claim access now

    For current subscribers with Society Membership or Account Number.

  • Visit SciVerse ScienceDirect to see if you have access via your institution.

 Conflicts of interest Paul Rutgeerts, William Sandborn, Jean Frédéric Colombel, Stephen Hanauer, Gary Lichtenstein, Walter Reinisch, Bruce Sands, and Brian Feagan have served as consultants for Centocor Research & Development, a division of Johnson & Johnson Pharmaceutical Research & Development, LLC and Schering–Plough, a subsidiary of Merck & Co, Inc; Paul Rutgeerts, William Sandborn, Stephen Hanauer, Bruce Sands, Brian Feagan, Walter Reinisch, and Gary Lichtenstein have participated in continuing medical education events supported by unrestricted educational grants from Centocor Research & Development, a division of Johnson & Johnson Pharmaceutical Research & Development, LLC and Schering Corporation, a subsidiary of Merck & Co, Inc; Björn Oddens and Yanxin Wang are employees of Schering Corporation, a subsidiary of Merck & Co, Inc; Colleen Marano and Richard Strauss are employees of the Department of Immunology, Centocor Research & Development, a division of Johnson & Johnson Pharmaceutical Research & Development, LLC, and Yinghua Lang is an employee of the Department of Biostatistics, Centocor Research & Development, a division of Johnson & Johnson Pharmaceutical Research & Development, LLC; and Dirk Esser is a former employee of Janssen Biologics BV and is currently an employee of Boerhringer–Ingelheim.

 Funding Supported by a research grant from Centocor Research & Development, a division of Johnson & Johnson Pharmaceutical Research & Development, LLC (Malvern, PA) and Schering Corporation, a subsidiary of Merck & Co, Inc (Kenilworth, NJ); this study was designed and conducted by the ACT-1 and ACT-2 Steering Committees, Centocor Research & Development, a division of Johnson & Johnson Pharmaceutical Research & Development, LLC and Schering Corporation (a subsidiary of Merck & Co, Inc) who jointly analyzed and interpreted the data, and contributed to the manuscript; Drs Colombel, Rutgeerts, and Sandborn prepared the first draft of the manuscript, and the ACT-1 and ACT-2 Steering Committee made the decision to publish; editorial and writing support was provided by James P. Barrett, an employee of the Medical Affairs Publications Group, Janssen Services, LLC.

PII: S0016-5085(11)00904-8

doi:10.1053/j.gastro.2011.06.054

Gastroenterology
Volume 141, Issue 4 , Pages 1194-1201, October 2011

Article Tools

* Image Usage & Resolution