Gastroenterology
Volume 141, Issue 4 , Pages 1194-1201 , October 2011

Early Mucosal Healing With Infliximab Is Associated With Improved Long-term Clinical Outcomes in Ulcerative Colitis

  • Jean Frédéric Colombel

      Affiliations

    • Department of Hepatogastroenterology, CHU Lille and INSERM-CIC9301, Universite Lille Nord de France
    • Corresponding Author InformationReprint requests Address requests for reprints to: Jean Frédéric Colombel, MD, Hopital Claude Huriez, Centre Hopitalier Universitaire de Lille, Rue Michel Polonovski, Lille, France 59037. fax: (33) 3-20-44-47-13
    • ,
  • Paul Rutgeerts

      Affiliations

    • Department of Gastroenterology, University Hospital Gasthuisberg, Leuven, Belgium
    • ,
  • Walter Reinisch

      Affiliations

    • Department of Gastroenterology and Hepatology, Universität Klinik für Innere Medizin III, AKH Wien, Vienna, Austria
    • ,
  • Dirk Esser

      Affiliations

    • Janssen Biologics, BV, Leiden, The Netherlands
    • ,
  • Yanxin Wang

      Affiliations

    • Schering Corporation, Subsidiary of Merck & Co, Inc, Kenilworth, New Jersey
    • ,
  • Yinghua Lang

      Affiliations

    • Department of Biostatistics, Centocor Research & Development, a division of Johnson & Johnson Pharmaceutical Research & Development, LLC, Malvern, Pennsylvania
    • ,
  • Colleen W. Marano

      Affiliations

    • Department of Immunology, Centocor Research & Development, a division of Johnson & Johnson Pharmaceutical Research & Development, LLC, Malvern, Pennsylvania
    • ,
  • Richard Strauss

      Affiliations

    • Department of Immunology, Centocor Research & Development, a division of Johnson & Johnson Pharmaceutical Research & Development, LLC, Malvern, Pennsylvania
    • ,
  • Björn J. Oddens

      Affiliations

    • Schering Corporation, Subsidiary of Merck & Co, Inc, Kenilworth, New Jersey
    • ,
  • Brian G. Feagan

      Affiliations

    • Robarts Research Institute, University of Western Ontario, London, Ontario, Canada
    • ,
  • Stephen B. Hanauer

      Affiliations

    • University of Chicago, Chicago, Illinois
    • ,
  • Gary R. Lichtenstein

      Affiliations

    • University of Pennsylvania, Philadelphia, Pennsylvania
    • ,
  • Daniel Present

      Affiliations

    • Mount Sinai Medical Center, New York, New York
    • ,
  • Bruce E. Sands

      Affiliations

    • Mount Sinai Medical Center, New York, New York
    • ,
  • William J. Sandborn

      Affiliations

    • University of California San Diego, La Jolla, California

Received 22 December 2010 ,Accepted 17 June 2011.

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 Conflicts of interest Paul Rutgeerts, William Sandborn, Jean Frédéric Colombel, Stephen Hanauer, Gary Lichtenstein, Walter Reinisch, Bruce Sands, and Brian Feagan have served as consultants for Centocor Research & Development, a division of Johnson & Johnson Pharmaceutical Research & Development, LLC and Schering–Plough, a subsidiary of Merck & Co, Inc; Paul Rutgeerts, William Sandborn, Stephen Hanauer, Bruce Sands, Brian Feagan, Walter Reinisch, and Gary Lichtenstein have participated in continuing medical education events supported by unrestricted educational grants from Centocor Research & Development, a division of Johnson & Johnson Pharmaceutical Research & Development, LLC and Schering Corporation, a subsidiary of Merck & Co, Inc; Björn Oddens and Yanxin Wang are employees of Schering Corporation, a subsidiary of Merck & Co, Inc; Colleen Marano and Richard Strauss are employees of the Department of Immunology, Centocor Research & Development, a division of Johnson & Johnson Pharmaceutical Research & Development, LLC, and Yinghua Lang is an employee of the Department of Biostatistics, Centocor Research & Development, a division of Johnson & Johnson Pharmaceutical Research & Development, LLC; and Dirk Esser is a former employee of Janssen Biologics BV and is currently an employee of Boerhringer–Ingelheim.

 Funding Supported by a research grant from Centocor Research & Development, a division of Johnson & Johnson Pharmaceutical Research & Development, LLC (Malvern, PA) and Schering Corporation, a subsidiary of Merck & Co, Inc (Kenilworth, NJ); this study was designed and conducted by the ACT-1 and ACT-2 Steering Committees, Centocor Research & Development, a division of Johnson & Johnson Pharmaceutical Research & Development, LLC and Schering Corporation (a subsidiary of Merck & Co, Inc) who jointly analyzed and interpreted the data, and contributed to the manuscript; Drs Colombel, Rutgeerts, and Sandborn prepared the first draft of the manuscript, and the ACT-1 and ACT-2 Steering Committee made the decision to publish; editorial and writing support was provided by James P. Barrett, an employee of the Medical Affairs Publications Group, Janssen Services, LLC.

PII: S0016-5085(11)00904-8

doi: 10.1053/j.gastro.2011.06.054

Gastroenterology
Volume 141, Issue 4 , Pages 1194-1201 , October 2011

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