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Gastroenterology
Volume 139, Issue 5
, Pages 1740-1752
, November 2010
Autophagy Reduces Acute Ethanol-Induced Hepatotoxicity and Steatosis in Mice
References
- . Determinants of alcohol use and abuse: impact of quantity and frequency patterns on liver disease. Hepatology. 2007;46:2032–2039
- . Alcoholic liver disease. Curr Opin Gastroenterol. 2000;16:208–218
- . Contribution of mitochondria to oxidative stress associated with alcoholic liver disease. Free Radic Biol Med. 2002;32:11–16
- . Binge ethanol exposure increases liver injury in obese rats. Gastroenterology. 2003;125:1818–1833
- . Alcoholic fatty liver: its pathogenesis and mechanism of progression to inflammation and fibrosis. Alcohol. 2004;34:9–19
- . Acute ethanol exposure inhibits insulin signaling in the liver. Hepatology. 2007;46:1791–1800
- . CYP2E1 and oxidative liver injury by alcohol. Free Radic Biol Med. 2008;44:723–738
- . Hepatic steatosis: innocent bystander or guilty party?. Hepatology. 1998;27:1463–1466
- . Methods in mammalian autophagy research. Cell. 2010;140:313–326
- In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker. Mol Biol Cell. 2004;15:1101–1111
- . Development and characterization of a binge drinking model in mice for evaluation of the immunological effects of ethanol. Alcohol Clin Exp Res. 1996;20:132–138
- Bid-dependent generation of oxygen radicals promotes death receptor activation-induced apoptosis in murine hepatocytes. Hepatology. 2004;40:403–413
- . Recombinant Hep G2 cells that express alcohol dehydrogenase and cytochrome P450 2E1 as a model of ethanol-elicited cytotoxicity. Int J Biochem Cell Biol. 2006;38:92–101
- Correction of diet-induced hyperglycemia, hyperinsulinemia, and skeletal muscle insulin resistance by moderate hyperleptinemia. Am J Physiol Endocrinol Metab. 2000;278:E563–E569
- Impaired autophagic flux mediates acinar cell vacuole formation and trypsinogen activation in rodent models of acute pancreatitis. J Clin Invest. 2009;119:3340–3355
- A role for ubiquitin in selective autophagy. Mol Cell. 2009;34:259–269
- . Ethanol-induced apoptosis in mouse liver: Fas- and cytochrome c-mediated caspase-3 activation pathway. Am J Pathol. 2001;159:329–338
- The mitochondrial permeability transition contributes to acute ethanol-induced apoptosis in rat hepatocytes. Hepatology. 2001;34:320–328
- Role of MAPK phosphatase-1 in sustained activation of JNK during ethanol-induced apoptosis in hepatocyte-like VL-17A cells. J Biol Chem. 2007;282:31900–31908
- The mitochondrial permeability transition initiates autophagy in rat hepatocytes. FASEB J. 2001;15:2286–2287
- Atg32 is a mitochondrial protein that confers selectivity during mitophagy. Dev Cell. 2009;17:98–109
- Impaired adaptive resynthesis and prolonged depletion of hepatic mitochondrial DNA after repeated alcohol binges in mice. Gastroenterology. 2002;123:1278–1290
- Autophagy regulates lipid metabolism. Nature. 2009;458:1131–1135
- . Is mitochondrial generation of reactive oxygen species a trigger for autophagy?. Autophagy. 2008;4:246–248
- Oxidative stress induces parallel autophagy and mitochondria dysfunction in human glioma U251 cells. Toxicol Sci. 2009;110:376–388
- Autophagy fights disease through cellular self-digestion. Nature. 2008;451:1069–1075
- . Animla models of ethanol-induced liver injury. In: Sherman DIN, Preedy V, Watson RR editor. Ethanol and the liver. London and New York: Taylor & Francis, Inc; 2002;p. 358–386
- . Selective degradation of mitochondria by mitophagy. Arch Biochem Biophys. 2007;462:245–253
Conflicts of interest The authors disclose no conflicts.
Funding Supported in part by NIH (R01 CA83817, R01 CA111456 to X.-M.Y.; R01 AA11291 to D.L.C.; R21 AA017421 to W.-X.D.) and the Department of Veterans Affairs (to D.L.C.).
PII: S0016-5085(10)01104-2
doi: 10.1053/j.gastro.2010.07.041
© 2010 AGA Institute. Published by Elsevier Inc. All rights reserved.
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Gastroenterology
Volume 139, Issue 5
, Pages 1740-1752
, November 2010

