Gastroenterology
Volume 139, Issue 5 , Pages 1677-1685.e8 , November 2010

Genetic Heterogeneity in Colorectal Cancer Associations Between African and European Americans

  • Sonia S. Kupfer

      Affiliations

    • Department of Medicine, Section of Gastroenterology, University of Chicago Medical Center, Chicago, Illinois
    • ,
  • Jeffrey R. Anderson

      Affiliations

    • Department of Medicine, Section of Gastroenterology, University of Chicago Medical Center, Chicago, Illinois
    • ,
  • Stanley Hooker

      Affiliations

    • Department of Medicine, Section of Genetic Medicine, University of Chicago Medical Center, Chicago, Illinois
    • ,
  • Andrew Skol

      Affiliations

    • Department of Medicine, Section of Genetic Medicine, University of Chicago Medical Center, Chicago, Illinois
    • ,
  • Rick A. Kittles

      Affiliations

    • Department of Medicine, Section of Genetic Medicine, University of Chicago Medical Center, Chicago, Illinois
    • ,
  • Temitope O. Keku

      Affiliations

    • Department of Medicine, Division of Gastroenterology and Hepatology, University of North Carolina, Chapel Hill, North Carolina
    • ,
  • Robert S. Sandler

      Affiliations

    • Department of Medicine, Division of Gastroenterology and Hepatology, University of North Carolina, Chapel Hill, North Carolina
    • ,
  • Nathan A. Ellis

      Affiliations

    • Department of Medicine, Section of Gastroenterology, University of Chicago Medical Center, Chicago, Illinois
    • Corresponding Author InformationReprint requests Address requests for reprints to: Nathan A. Ellis, PhD, Department of Medicine, Section of Gastroenterology, University of Chicago Medical Center, 900 East 57th Street, 9th Floor, Chicago, Illinois 60637

Received 1 April 2010 ,Accepted 16 July 2010.

References 

  1. Houlston RS, Webb E, Broderick P, et al. Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer. Nat Genet. 2008;40:1426–1435
  2. Pomerantz MM, Ahmadiyeh N, Jia L, et al. The 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer. Nat Genet. 2009;41:882–884
  3. Tuupanen S, Turunen M, Lehtonen R, et al. The common colorectal cancer predisposition SNP rs6983267 at chromosome 8q24 confers potential to enhanced Wnt signaling. Nat Genet. 2009;41:885–890
  4. Bodmer W, Bonilla C. Common and rare variants in multifactorial susceptibility to common diseases. Nat Genet. 2008;40:695–701
  5. Tenesa A, Dunlop MG. New insights into the aetiology of colorectal cancer from genome-wide association studies. Nat Rev Genet. 2009;10:353–358
  6. American Cancer Society. Cancer Facts and Figures 2010. Atlanta: American Cancer Society; 2010;
  7. Alexander DD, Waterbor J, Hughes T, et al. African-American and Caucasian disparities in colorectal cancer mortality and survival by data source: an epidemiologic review. Cancer Biomark. 2007;3:301–313
  8. Kupfer SS, Torres JB, Hooker S, et al. Novel single nucleotide polymorphism associations with colorectal cancer on chromosome 8q24 in African and European Americans. Carcinogenesis. 2009;30:1353–1357
  9. Weinberg CR, Sandler DP. Randomized recruitment in case-control studies. Am J Epidemiol. 1991;134:421–432
  10. Sansbury LB, Millikan RC, Schroeder JC, et al. COX-2 polymorphism, use of nonsteroidal anti-inflammatory drugs, and risk of colon cancer in African Americans (United States). Cancer Causes Control. 2006;17:257–266
  11. Robbins C, Torres JB, Hooker S, et al. Confirmation study of prostate cancer risk variants at 8q24 in African Americans identifies a novel risk locus. Genome Res. 2007;17:1717–1722
  12. Haiman CA, Le Marchand L, Yamamato J, et al. A common genetic risk factor for colorectal and prostate cancer. Nat Genet. 2007;39:954–956
  13. Falush D, Stephens M, Pritchard JK. Inference of population structure using multilocus genotype data: linked loci and correlated allele frequencies. Genetics. 2003;164:1567–1587
  14. Rosenberg NA, Huang L, Jewett EM, et al. Genome-wide association studies in diverse populations. Nat Rev Genet. 2010;11:356–366
  15. Purcell S, Neale B, Todd-Brown K, et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet. 2007;81:559–575
  16. Barrett JC, Fry B, Maller J, et al. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics. 2005;21:263–265
  17. Tomlinson I, Webb E, Carvajal-Carmona L, et al. A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21. Nat Genet. 2007;39:984–988
  18. Tenesa A, Farrington SM, Prendergast JG, et al. Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21. Nat Genet. 2008;40:631–637
  19. Li L, Plummer SJ, Thompson CL, et al. A common 8q24 variant and the risk of colon cancer: a population-based case-control study. Cancer Epidemiol Biomarkers Prev. 2008;17:339–342
  20. Berndt SI, Potter JD, Hazra A, et al. Pooled analysis of genetic variation at chromosome 8q24 and colorectal neoplasia risk. Hum Mol Genet. 2008;17:2665–2672
  21. Schafmayer C, Buch S, Volzke H, et al. Investigation of the colorectal cancer susceptibility region on chromosome 8q24.21 in a large German case-control sample. Int J Cancer. 2009;124:75–80
  22. Sotelo J, Esposito D, Duhagon MA, et al. Long-range enhancers on 8q24 regulate c-Myc. Proc Natl Acad Sci U S A. 2010;107:3001–3005
  23. Wright JB, Brown SJ, Cole MD. Up-regulation of c-MYC in cis through a large chromatin loop linked to a cancer risk-associated single-nucleotide polymorphism in colorectal cancer cells. Mol Cell Biol. 2010;30:1411–1420
  24. Wordinger RJ, Zode G, Clark AF. Focus on molecules: gremlin. Exp Eye Res. 2008;87:78–79
  25. Tomlinson I, Rahman N, Frayling I, et al. Inherited susceptibility to colorectal adenomas and carcinomas: evidence for a new predisposition gene on 15q14-q22. Gastroenterology. 1999;116:789–795
  26. Daley D, Lewis S, Platzer P, et al. Identification of susceptibility genes for cancer in a genome-wide scan: results from the colon neoplasia sibling study. Am J Hum Genet. 2008;82:723–736
  27. Pittman AM, Webb E, Carvajal-Carmona L, et al. Refinement of the basis and impact of common 11q23.1 variation to the risk of developing colorectal cancer. Hum Mol Genet. 2008;17:3720–3727
  28. Tomlinson IP, Webb E, Carvajal-Carmona L, et al. A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3. Nat Genet. 2008;40:623–630
  29. Zeggini E, Scott LJ, Saxena R, et al. Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet. 2008;40:638–645

 Conflicts of interest The authors disclose no conflicts.

 Funding Supported by The Cancer Research Foundation, the Department of Medicine at the University of Chicago, the Digestive Disease Research Core Center (P30 DK42086), an American Cancer Society Institutional research grant, the University of Chicago Comprehensive Cancer Research Center and Clinical Translational Science Award, the University of North Carolina Digestive Disease Research Core Center (P30 DK34987), and grants from the National Cancer Institute (R01 CA66635) to R.S.S., U01 CA153060 to N.A.E., and K08 CA142892 to S.S.K. This report is solely the opinion of the authors and does not represent the official views of the National Cancer Institute or the National Institutes of Health.

PII: S0016-5085(10)01101-7

doi: 10.1053/j.gastro.2010.07.038

Gastroenterology
Volume 139, Issue 5 , Pages 1677-1685.e8 , November 2010

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