This Month in Gastroenterology

Summary of outcomes of undiagnosed celiac disease cases compared with serology-negative controls. Odds ratio (95% CI) from conditional logistic regression.

Kaplan–Meier estimates of recurrent venous thromboembolism after a first unprovoked venous thromboembolism in patients with (IBD) and without IBD (controls).

Direct cell-to-cell interaction between lamina propria (LP) NK cells and LP CD14⁺ macrophages (Co = co-culture) that produce IL-23 is required to produce IFN-γ protein. With commensal bacterial stimulation (E faecalis), co-culture causes a marked increase in IFN-γ production that was blocked with anti–IL-23 antibodies (α23). iso, non-IL23 antibody; tw, tap water control.

Only ATX activity, but not histamine, nor tryptase, substance P, serum bile salts or μ-opiod activity in serum correlated with itch intensity of patients with cholestatic itch. ATX activity showed a significant linear correlation with the itch intensity represented as a visual analogue scale ranging from 0 (no pruritis) to 10 (most severe form of pruritis; Spearman's correlation coefficient; r = 0.7764; P < .0001).