Gastroenterology
Volume 139, Issue 3 , Pages 729-731 , September 2010

Cadaveric Hepatocytes Repopulate Diseased Livers: Life After Death

  • David C. Hay

      Affiliations

    • Corresponding Author InformationReprint requests Address requests for reprints to: Dr David C. Hay, Research Council UK Research Fellow, MRC Centre for Regenerative Medicine, Chancellor's Building, 49 Little France Crescent, University of Edinburgh, Edinburgh EH16 4SB, United Kingdom. fax (44) 0131 242 6299

References 

  1. Azuma H, Paulk N, Ranade A, et al. Robust expansion of human hepatocytes in Fah(-/-)/Rag2(-/-)/Il2rg(-/-) mice. Nature Biotechnology. 2007;25:903–910
  2. Zern MA. Cell transplantation to replace whole liver transplantation. Gastroenterology. 2009;136:767–769
  3. Sharma R, Greenhough S, Medine CN, et al. Three-dimensional culture of human embryonic stem cell derived hepatic endoderm and its role in bioartificial liver construction. J Biomed Biotechnol. 2010;2010:236147
  4. Delgado JP, Parouchev A, Allain JE, et al. Long-term controlled immortalization of a primate hepatic progenitor cell line 347 after Simian virus 40 T-Antigen gene transfer. Oncogene. 2005;24:541–551
  5. Czyz J, Wiese C, Rolletschek A, et al. Potential of embryonic and adult stem cells in vitro. Biol Chem. 2003;384:1391–1409
  6. Hay DC, Fletcher J, Payne C, et al. Highly efficient differentiation of hESCs to functional hepatic endoderm requires ActivinA and Wnt3a signaling. Proc Natl Acad Sci U S A. 2008;105:12301–12306
  7. Basma H, Soto-Gutiérrez A, Yannam GR, et al. Differentiation and transplantation of human embryonic stem cell-derived hepatocytes. Gastroenterology. 2009;136:990–999
  8. Sullivan GJ, Hay DC, Park IH, et al. Generation of functional human hepatic endoderm from human induced pluripotent stem cells. Hepatology. 2010;51:329–335
  9. Si-Tayeb K, Noto FK, Nagaoka M, et al. Highly efficient generation of human hepatocyte-like cells from induced pluripotent stem cells. Hepatology. 2010;51:297–305
  10. Touboul T, Hannan NR, Corbineau S, et al. Generation of functional hepatocytes from human embryonic stem cells under chemically defined conditions that recapitulate liver development. Hepatology. 2010;51:1754–1765
  11. Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell. 2006;126:663–676
  12. Takahashi K, Tanabe K, Ohnuki M, et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell. 2007;131:861–872
  13. Dalgetty DM, Medine CN, Iredale JP, et al. Progress and future challenges in stem cell-derived liver technologies. Am J Physiol Gastrointest Liver Physiol. 2009;297:G241–G248
  14. Gallicano GI, Mishra L. Hepatocytes from induced pluripotent stem cells: a giant leap forward for hepatology. Hepatology. 2010;51:20–22
  15. Erker L, Azuma H, Lee AY, et al. Therapeutic liver reconstitution with murine cells isolated long after death. Gastroenterology. 2010;139:1019–1029
  16. Hughes RD, Mitry RR, Dhawan A, et al. Isolation of hepatocytes from livers from non-heart beating donors for cell transplantation. Liver Transplant. 2006;12:713–717

 Conflicts of interest The author discloses no conflicts.

PII: S0016-5085(10)01065-6

doi: 10.1053/j.gastro.2010.07.013

Gastroenterology
Volume 139, Issue 3 , Pages 729-731 , September 2010

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