Gastroenterology
Volume 139, Issue 3 , Pages 893-903 , September 2010

Indian Hedgehog Regulates Intestinal Stem Cell Fate Through Epithelial−Mesenchymal Interactions During Development

  • Cynthia Kosinski

      Affiliations

    • Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California
    • ,
  • Daniel E. Stange

      Affiliations

    • Hubrecht Institute, KNAW and University Medical Center Utrecht, Utrecht, The Netherlands
    • ,
  • Chuanrui Xu

      Affiliations

    • Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California
    • ,
  • Annie Sy Chan

      Affiliations

    • Department of Pathology and Center for Cancer Research, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong
    • ,
  • Coral Ho

      Affiliations

    • Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California
    • ,
  • Siu Tsan Yuen

      Affiliations

    • Department of Pathology and Center for Cancer Research, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong
    • ,
  • Randy C. Mifflin

      Affiliations

    • Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas
    • ,
  • Don W. Powell

      Affiliations

    • Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas
    • ,
  • Hans Clevers

      Affiliations

    • Hubrecht Institute, KNAW and University Medical Center Utrecht, Utrecht, The Netherlands
    • ,
  • Suet Yi Leung

      Affiliations

    • Department of Pathology and Center for Cancer Research, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong
    • Corresponding Author InformationSuet-Yi Leung, MD, FRCPath, Department of Pathology, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong. fax: (852) 2872-5197
    • ,
  • Xin Chen

      Affiliations

    • Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California
    • Corresponding Author InformationReprint requests Address requests for reprints to: Xin Chen, PhD, Department of Bioengineering and Therapeutic Sciences, University of California, 513 Parnassus Avenue, San Francisco, California 94143. fax: (415) 502-4322

Received 18 December 2009 ,Accepted 1 June 2010.

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 Transcript profiling: The raw data of microarray experiment are available at Gene Expression Omnibus (GEO, http://www.ncbi.nlm.nih.gov/projects/geo) under the accession number of GSE18393.

 Conflicts of interest The authors disclose no conflicts.

 Funding This work is supported in part by National Institutes of Health grants R21DK069309 and R01CA136606 to X.C.; R01CA127229 and R01DK55783 to D.W.P.; a grant from the Research Grants Council of the Hong Kong Special Administrative Region (Project No. HKU7524/06M) to S.Y.L. and X.C.; a grant from Strategic Research Theme on Cancer from The University of Hong Kong to S.Y.L. C.K. is supported by a stem cell fellowship provided by the California Institute for Regenerative Medicine; and D.E.S. is supported by Deutsche Forschungsgemeinschaft (DFG, Sta1065/1-1). The funding agencies have no role in data collection, analysis, and interpretation.

PII: S0016-5085(10)00873-5

doi: 10.1053/j.gastro.2010.06.014

Gastroenterology
Volume 139, Issue 3 , Pages 893-903 , September 2010

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