Gastroenterology
Volume 139, Issue 3 , Pages 821-827.e1, September 2010

An IL28B Polymorphism Determines Treatment Response of Hepatitis C Virus Genotype 2 or 3 Patients Who Do Not Achieve a Rapid Virologic Response

  • Alessandra Mangia

      Affiliations

    • Liver Unit, Instituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Casa Sollievo della Sofferenza Hospital, San Giovanni Rotondo, Italy
    • Corresponding Author InformationReprint requests Address requests for reprints to: Alessandra Mangia, MD, Gastroenterology Unit, IRCCS Casa Sollievo della Sofferenza Hospital, San Giovanni Rotondo, Italy. fax: (39) 0882-455161
    • ,
  • Alexander J. Thompson

      Affiliations

    • Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina
    • ,
  • Rosanna Santoro

      Affiliations

    • Liver Unit, Instituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Casa Sollievo della Sofferenza Hospital, San Giovanni Rotondo, Italy
    • ,
  • Valeria Piazzolla

      Affiliations

    • Liver Unit, Instituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Casa Sollievo della Sofferenza Hospital, San Giovanni Rotondo, Italy
    • ,
  • Hans L. Tillmann

      Affiliations

    • Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina
    • ,
  • Keyur Patel

      Affiliations

    • Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina
    • ,
  • Kevin V. Shianna

      Affiliations

    • Institute for Genome Sciences & Policy, Center for Human Genome Variation, Duke University Medical Center, Durham, North Carolina
    • ,
  • Leonardo Mottola

      Affiliations

    • Liver Unit, Instituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Casa Sollievo della Sofferenza Hospital, San Giovanni Rotondo, Italy
    • ,
  • Daniela Petruzzellis

      Affiliations

    • Liver Unit, Instituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Casa Sollievo della Sofferenza Hospital, San Giovanni Rotondo, Italy
    • ,
  • Donato Bacca

      Affiliations

    • Department of Internal Medicine, Hospital Casarano, Italy
    • ,
  • Vito Carretta

      Affiliations

    • Department of Internal Medicine, Hospital Venosa, Venosa, Italy
    • ,
  • Nicola Minerva

      Affiliations

    • Department of Internal Medicine, Hospital Canosa, Canosa, Italy
    • ,
  • David B. Goldstein

      Affiliations

    • Institute for Genome Sciences & Policy, Center for Human Genome Variation, Duke University Medical Center, Durham, North Carolina
    • ,
  • John G. McHutchison

      Affiliations

    • Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina

Received 17 February 2010; accepted 25 May 2010. published online 04 June 2010.

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 Conflicts of interest These authors disclose the following: Alexander Thompson, Kevin Shianna, David Goldstein, and John McHutchison are co-inventors of a patent application based on the interleukin-28B discovery. The remaining authors disclose no conflicts.

 Funding Supported by funding from the Duke Clinical Research Institute, a generous research gift from the Richard B. Boebel Family Fund, the National Health and Medical Research Council of Australia, the Gastroenterology Society of Australia, and the Royal Australasian College of Physicians (A.J.T.).

PII: S0016-5085(10)00841-3

doi:10.1053/j.gastro.2010.05.079

Gastroenterology
Volume 139, Issue 3 , Pages 821-827.e1, September 2010

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