Gastroenterology
Volume 138, Issue 7 , Pages 2207-2210.e1 , June 2010

Spasmolytic Polypeptide-Expressing Metaplasia and Intestinal Metaplasia: Time for Reevaluation of Metaplasias and the Origins of Gastric Cancer

  • James R. Goldenring

      Affiliations

    • Nashville VA Medical Center and the Epithelial Biology Center and Departments of Surgery and Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee
  • ,
  • Ki Taek Nam

      Affiliations

    • Nashville VA Medical Center and the Epithelial Biology Center and Departments of Surgery and Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee
  • ,
  • Timothy C. Wang

      Affiliations

    • Associate Editor and Irving Cancer Research Center, Department of Medicine, Columbia University Medical Center, New York, New York
  • ,
  • Jason C. Mills

      Affiliations

    • Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri
  • ,
  • Nicholas A. Wright

      Affiliations

    • Barts and The London Medical School, Histopathology Unit, Cancer Research UK London Research Institute, London, United Kingdom

References 

  1. Correa P. A human model of gastric carcinogenesis. Cancer Res. 1988;48:3554–3560
  2. Rokkas T, Filipe MI, Sladen GE. Detection of an increased incidence of early gastric cancer in patients with intestinal metaplasia type III who are closely followed up. Gut. 1991;32:1110–1113
  3. Zivny J, Wang TC, Yantiss R, et al. 2003 Role of therapy or monitoring in preventing progression to gastric cancer. J Clin Gastroenterol. 2003;36:S50–S60
  4. Schmidt PH, Lee JR, Joshi V, et al. Identification of a metaplastic cell lineage associated with human gastric adenocarcinoma. Lab Invest. 1999;79:639–646
  5. Lax I, Bellot F, Honegger A, et al. Functional analysis of the ligand binding site of EGF-receptor utilizing chimeric chicken/human receptor molecules. EMBO J. 1989;8:421–427

PII: S0016-5085(10)00594-9

doi: 10.1053/j.gastro.2010.04.023

Gastroenterology
Volume 138, Issue 7 , Pages 2207-2210.e1 , June 2010