Gastroenterology
Volume 138, Issue 7 , Pages 2202-2206.e1 , June 2010

Genetic Testing in Pancreatitis

  • Chee Y. Ooi

      Affiliations

    • Research Institute and Division of Gastroenterology, Hepatology and Nutrition Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada
  • ,
  • Tanja Gonska

      Affiliations

    • Research Institute and Division of Gastroenterology, Hepatology and Nutrition Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada
  • ,
  • Peter R. Durie

      Affiliations

    • Research Institute and Division of Gastroenterology, Hepatology and Nutrition Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada
  • ,
  • Steven D. Freedman

      Affiliations

    • Division of Gastroenterology, Beth Israel Deaconess Medical Center and Harvard Medical School Boston, Massachusetts
    • Corresponding Author InformationReprint requests Address requests for reprints to: Steven D. Freedman, MD, PhD, Beth Israel Deaconess Medical Center, 330 Brookline Ave., Dana 501, Boston, Massachusetts 02215

References 

  1. Marino CR, Matovcik LM, Gorelick FS, et al. Localization of the cystic fibrosis transmembrane conductance regulator in pancreas. J Clin Invest. 1991;88:712–716
  2. Oppenheimer EH, Esterly JR. Pathology of cystic fibrosis: review of the literature and comparison with 146 autopsied cases. Perspect Pediatr Pathol. 1976;2:241–278
  3. Zeng W, Lee MG, Yan M, et al. Immuno and functional characterization of CFTR in submandibular and pancreatic acinar and duct cells. Am J Physiol. 1997;273:C442–C455
  4. Freedman SD, Kern H, Scheele GA. Pancreatic acinar cell dysfunction in cftr (-/-) mice is associated with impairments in luminal pH and endocytosis. Gastroenterology. 2001;121:950–957
  5. Giljam K, Ellis L, Corey M, et al. Clinical manifestations of cystic fibrosis among patients diagnosed in adulthood. Chest. 2004;126;:1215–1224

 Conflicts of interest The authors disclose no conflicts.

PII: S0016-5085(10)00593-7

doi: 10.1053/j.gastro.2010.04.022

Gastroenterology
Volume 138, Issue 7 , Pages 2202-2206.e1 , June 2010