Gastroenterology
Volume 139, Issue 1 , Pages 120-129.e18 , July 2010

Interleukin-28B Polymorphism Improves Viral Kinetics and Is the Strongest Pretreatment Predictor of Sustained Virologic Response in Genotype 1 Hepatitis C Virus

  • Alexander J. Thompson

      Affiliations

    • Duke Clinical Research Institute, Durham, North Carolina
    • ,
  • Andrew J. Muir

      Affiliations

    • Duke Clinical Research Institute, Durham, North Carolina
    • Duke University Medical Center, Durham, North Carolina
    • ,
  • Mark S. Sulkowski

      Affiliations

    • Johns Hopkins University School of Medicine, Baltimore, Maryland
    • ,
  • Dongliang Ge

      Affiliations

    • Center for Human Genome Variation, Duke University, Durham, North Carolina
    • ,
  • Jacques Fellay

      Affiliations

    • Center for Human Genome Variation, Duke University, Durham, North Carolina
    • ,
  • Kevin V. Shianna

      Affiliations

    • Center for Human Genome Variation, Duke University, Durham, North Carolina
    • ,
  • Thomas Urban

      Affiliations

    • Center for Human Genome Variation, Duke University, Durham, North Carolina
    • ,
  • Nezam H. Afdhal

      Affiliations

    • Beth Israel Deaconess Medical Centre, Boston, Massachusetts
    • ,
  • Ira M. Jacobson

      Affiliations

    • Weill Cornell Medical College, New York, New York
    • ,
  • Rafael Esteban

      Affiliations

    • Hospital General Universitario Valle de Hebron, Barcelona, Spain
    • ,
  • Fred Poordad

      Affiliations

    • Cedars-Sinai Medical Center, Los Angeles, California
    • ,
  • Eric J. Lawitz

      Affiliations

    • Alamo Medical Research, San Antonio, Texas
    • ,
  • Jonathan McCone

      Affiliations

    • Mt. Vernon Endoscopy Center, Alexandria, Virginia
    • ,
  • Mitchell L. Shiffman

      Affiliations

    • Liver Institute of Virginia, Newport News, Virginia
    • ,
  • Greg W. Galler

      Affiliations

    • Kelsey Research Foundation, Houston, Texas
    • ,
  • William M. Lee

      Affiliations

    • University of Texas Southwestern Medical Center, Dallas, Texas
    • ,
  • Robert Reindollar

      Affiliations

    • Piedmont Healthcare, Statesville, North Carolina
    • ,
  • John W. King

      Affiliations

    • Louisiana State University, Shreveport, Louisiana
    • ,
  • Paul Y. Kwo

      Affiliations

    • Indiana University School of Medicine, Indianapolis, Indiana
    • ,
  • Reem H. Ghalib

      Affiliations

    • The Liver Institute at Methodist Dallas Medical Center, Dallas, Texas
    • ,
  • Bradley Freilich

      Affiliations

    • Kansas City Gastroenterology and Hepatology, Kansas City, Missouri
    • ,
  • Lisa M. Nyberg

      Affiliations

    • Kaiser Permanente, San Diego, California
    • ,
  • Stefan Zeuzem

      Affiliations

    • J.W. Goethe-University Hospital, Frankfurt, Germany
    • ,
  • Thierry Poynard

      Affiliations

    • Groupe Hospitalier Pitie-Salpetriere, Paris, France
    • ,
  • David M. Vock

      Affiliations

    • Duke Clinical Research Institute, Durham, North Carolina
    • ,
  • Karen S. Pieper

      Affiliations

    • Duke Clinical Research Institute, Durham, North Carolina
    • ,
  • Keyur Patel

      Affiliations

    • Duke Clinical Research Institute, Durham, North Carolina
    • Duke University Medical Center, Durham, North Carolina
    • ,
  • Hans L. Tillmann

      Affiliations

    • Duke Clinical Research Institute, Durham, North Carolina
    • Duke University Medical Center, Durham, North Carolina
    • ,
  • Stephanie Noviello

      Affiliations

    • Schering-Plough Research Institute, Kenilworth, NJ
    • ,
  • Kenneth Koury

      Affiliations

    • Schering-Plough Research Institute, Kenilworth, NJ
    • ,
  • Lisa D. Pedicone

      Affiliations

    • Schering-Plough Research Institute, Kenilworth, NJ
    • ,
  • Clifford A. Brass

      Affiliations

    • Schering-Plough Research Institute, Kenilworth, NJ
    • ,
  • Janice K. Albrecht

      Affiliations

    • Schering-Plough Research Institute, Kenilworth, NJ
    • ,
  • David B. Goldstein

      Affiliations

    • Center for Human Genome Variation, Duke University, Durham, North Carolina
    • ,
  • John G. McHutchison

      Affiliations

    • Duke Clinical Research Institute, Durham, North Carolina
    • Duke University Medical Center, Durham, North Carolina
    • Corresponding Author InformationReprint requests Address requests for reprints to: John G. McHutchison, MD, Duke Clinical Research Institute, Duke University Medical Center, PO Box 17969, Durham, North Carolina 27715. fax: (919) 668-7164

Received 31 December 2009 ,Accepted 8 April 2010.

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 Conflicts of interest The authors disclose the following: Drs McHutchison, Goldstein, Muir, Afdhal, Jacobson, Esteban, Poordad, Lawitz, McCone, Shiffman, Galler, Lee, Reindollar, King, Kwo, Ghalib, Freilich, Nyberg, Patel, Zeuzem, Poynard, and Sulkowski report having received research and grant support from Schering-Plough; Drs McHutchison, Goldstein, Muir, Afdhal, Jacobson, Esteban, Poordad, Lawitz, Shiffman, Reindollar, Kwo, Zeuzem, Poynard, and Sulkowski have received consulting fees or acted in an advisory capacity for Schering-Plough; Drs Brass, Koury, Pedicone, and Albrecht are employees of Schering-Plough (now Merck & Co, Inc) and are stockholders in this entity; Dr Noviello is a former employee of Schering-Plough and is now a consultant to Merck & Co, Inc; and Drs Goldstein, Ge, Fellay, Shianna, Urban, McHutchison, and Thompson are co-inventors of a patent application based on this finding. David Vock and Karen Pieper declare that they have had access to all data and independent statistical support to allow them to analyze the data independently of the sponsor of the study.

 Funding This study was funded by Schering-Plough Research Institute, Kenilworth, NJ; Alexander Thompson received funding support from the Duke Clinical Research Institute, the Richard B. Boebel Family Fund, the National Health and Medical Research Council of Australia, and the Gastroenterology Society of Australia and the Royal Australasian College of Physicians.Jennifer King, PhD, provided editorial assistance in preparing the manuscript; she was funded by the Duke Clinical Research Institute, Duke University. The sponsor did not provide any funding for Dr King or have any contact with her.

PII: S0016-5085(10)00574-3

doi: 10.1053/j.gastro.2010.04.013

Gastroenterology
Volume 139, Issue 1 , Pages 120-129.e18 , July 2010

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