Gastroenterology
Volume 138, Issue 7 , Pages 2341-2347 , June 2010

Donor Race Does Not Predict Graft Failure After Liver Transplantation

  • Sumeet K. Asrani

      Affiliations

    • Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota
    • ,
  • Young–Suk Lim

      Affiliations

    • Asan Medical Center, Seoul, Korea
    • ,
  • Terry M. Therneau

      Affiliations

    • Division of Biomedical Statistics and Informatics, Mayo Clinic College of Medicine, Rochester, Minnesota
    • ,
  • Rachel A. Pedersen

      Affiliations

    • Division of Biomedical Statistics and Informatics, Mayo Clinic College of Medicine, Rochester, Minnesota
    • ,
  • Julie Heimbach

      Affiliations

    • William J. von Liebig Transplant Center, Mayo Clinic College of Medicine, Rochester, Minnesota
    • ,
  • W. Ray Kim

      Affiliations

    • Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota
    • William J. von Liebig Transplant Center, Mayo Clinic College of Medicine, Rochester, Minnesota
    • Corresponding Author InformationReprint requests Address requests for reprints to: W. Ray Kim, MD, 200 First Street SW, Rochester, Minnesota 55905. fax: (507) 538-3974

Received 25 November 2009 ,Accepted 9 February 2010.

References 

  1. Feng S, Goodrich NP, Bragg-Gresham JL, et al. Characteristics associated with liver graft failure: the concept of a donor risk index. Am J Transplant. 2006;6:783–790
  2. Ioannou GN. Development and validation of a model predicting graft survival after liver transplantation. Liver Transpl. 2006;12:1594–1606
  3. Schaubel DE, Guidinger MK, Biggins SW, et al. Survival benefit-based deceased-donor liver allocation. Am J Transplant. 2009;9:970–981
  4. Dawson S, Imagawa DK, Johnson C, et al. UCLA liver transplantation: analysis of immunological factors affecting outcome. Artif Organs. 1996;20:1063–1072
  5. Neylan JF. Racial differences in renal transplantation after immunosuppression with tacrolimus versus cyclosporine (FK506 Kidney Transplant Study Group). Transplantation. 1998;65:515–523
  6. Volk ML, Choi H, Warren GJ, et al. Geographic variation in organ availability is responsible for disparities in liver transplantation between Hispanics and Caucasians. Am J Transplant. 2009;9:2113–2118
  7. Lee TH, Shah N, Pedersen RA, et al. Survival after liver transplantation: is racial disparity inevitable?. Hepatology. 2007;46:1491–1497
  8. Wachs ME, Amend WJ, Ascher NL, et al. The risk of transmission of hepatitis B from HBsAg(−), HBcAb(+), HBIgM(−) organ donors. Transplantation. 1995;59:230–234
  9. Ahmad J, Bryce CL, Cacciarelli T, et al. Differences in access to liver transplantation: disease severity, waiting time, and transplantation center volume. Ann Intern Med. 2007;146:707–713
  10. Callender CO, Cherikh WS, Miles PV, et al. Blacks as donors for transplantation: suboptimal outcomes overcome by transplantation into other minorities. Transplant Proc. 2008;40:995–1000
  11. Eckhoff DE, McGuire BM, Young CJ, et al. Race: a critical factor in organ donation, patient referral and selection, and orthotopic liver transplantation?. Liver Transpl Surg. 1998;4:499–505
  12. Burroughs AK, Sabin CA, Rolles K, et al. 3-month and 12-month mortality after first liver transplant in adults in Europe: predictive models for outcome. Lancet. 2006;367:225–232
  13. Scarborough JE, Pietrobon R, Tuttle-Newhall JE, et al. Relationship between provider volume and outcomes for orthotopic liver transplantation. J Gastrointest Surg. 2008;12:1527–1533
  14. Schold JD, Srinivas TR, Howard RJ, et al. The association of candidate mortality rates with kidney transplant outcomes and center performance evaluations. Transplantation. 2008;85:1–6
  15. Centers for Medicare and Medicaid Services. Medicare program; hospital conditions of participation: requirements for approval and re-approval of transplant centers to perform organ transplants (Final rule). Fed Regist. 2007;72:15197–15280
  16. Kemmer N, Safdar K, Kaiser T, et al. Impact of geographic location on access to liver transplantation among ethnic minorities. Transplantation. 2008;85:166–170
  17. Marsman H, Matsushita T, Dierkhising R, et al. Assessment of donor liver steatosis: pathologist or automated software?. Hum Pathol. 2004;35:430–435
  18. Weston SR, Leyden W, Murphy R, et al. Racial and ethnic distribution of nonalcoholic fatty liver in persons with newly diagnosed chronic liver disease. Hepatology. 2005;41:372–379

 View this article's video abstract at www.gastrojournal.org.

 Conflicts of interest The authors disclose no conflicts.

 Funding This study was supported by a grant from the National Institutes of Health (R01DK-34238) and a National Institutes of Health digestive diseases training grant (T32 DK07198).

PII: S0016-5085(10)00197-6

doi: 10.1053/j.gastro.2010.02.008

Gastroenterology
Volume 138, Issue 7 , Pages 2341-2347 , June 2010

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