Gastroenterology
Volume 138, Issue 5 , Pages 1823-1835 , May 2010

A Novel Gastrokine, Gkn3, Marks Gastric Atrophy and Shows Evidence of Adaptive Gene Loss in Humans

  • Trevelyan R. Menheniott

      Affiliations

    • Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, Victoria, Australia
    • ,
  • Anthony J. Peterson

      Affiliations

    • Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, Victoria, Australia
    • ,
  • Louise O'Connor

      Affiliations

    • Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, Victoria, Australia
    • ,
  • Kai Syin Lee

      Affiliations

    • Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, Victoria, Australia
    • ,
  • Anastasia Kalantzis

      Affiliations

    • Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, Victoria, Australia
    • ,
  • Ivanela Kondova

      Affiliations

    • Biomedical Primate Research Center, Lange Kleiweg, GJ Rijswijk, The Netherlands
    • ,
  • Ronald E. Bontrop

      Affiliations

    • Biomedical Primate Research Center, Lange Kleiweg, GJ Rijswijk, The Netherlands
    • ,
  • Katrina M. Bell

      Affiliations

    • Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, Victoria, Australia
    • ,
  • Andrew S. Giraud

      Affiliations

    • Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, Victoria, Australia
    • Corresponding Author InformationReprint requests Address requests for reprints to: Andrew S. Giraud, PhD, Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, Victoria, 3052, Australia. fax: (61) 399366528

Received 16 November 2009 ,Accepted 27 January 2010.

References 

  1. Correa P, Piazuelo MB. Natural history of Helicobacter pylori infection. Dig Liver Dis. 2008;40:490–496
  2. El-Omar EM, Carrington M, Chow WH, et al. Interleukin-1 polymorphisms associated with increased risk of gastric cancer. Nature. 2000;404:398–402
  3. El-Omar EM, Rabkin CS, Gammon MD, et al. Increased risk of noncardia gastric cancer associated with proinflammatory cytokine gene polymorphisms. Gastroenterology. 2003;124:1193–1201
  4. Holcombe C. Helicobacter pylori: the African enigma. Gut. 1992;33:429–431
  5. Whary MT, Sundina N, Bravo LE, et al. Intestinal helminthiasis in Colombian children promotes a Th2 response to Helicobacter pylori: possible implications for gastric carcinogenesis. Cancer Epidemiol Biomarkers Prev. 2005;14:1464–1469
  6. Martin TE, Powell CT, Wang Z, et al. A novel mitogenic protein that is highly expressed in cells of the gastric antrum mucosa. Am J Physiol Gastrointest Liver Physiol. 2003;285:G332–G343
  7. Du JJ, Dou KF, Peng SY, et al. Down-regulated full-length novel gene GDDR and its effect on gastric cancer. Zhonghua Yi Xue Za Zhi. 2003;83:1166–1168
  8. Nardone G, Rippa E, Martin G, et al. Gastrokine 1 expression in patients with and without Helicobacter pylori infection. Dig Liver Dis. 2007;39:122–129
  9. Moss SF, Lee JW, Sabo E, et al. Decreased expression of gastrokine 1 and the trefoil factor interacting protein TFIZ1/GKN2 in gastric cancer: influence of tumor histology and relationship to prognosis. Clin Cancer Res. 2008;14:4161–4167
  10. Westley BR, Griffin SM, May FE. Interaction between TFF1, a gastric tumor suppressor trefoil protein, and TFIZ1, a BRICHOS domain-containing protein with homology to SP-C. Biochemistry. 2005;44:7967–7975
  11. Sanchez-Pulido L, Devos D, Valencia A. BRICHOS: a conserved domain in proteins associated with dementia, respiratory distress and cancer. Trends Biochem Sci. 2002;27:329–332
  12. Farrell JJ, Taupin D, Koh TJ, et al. TFF2/SP-deficient mice show decreased gastric proliferation, increased acid secretion, and increased susceptibility to NSAID injury. J Clin Invest. 2002;109:193–204
  13. Tebbutt NC, Giraud AS, Inglese M, et al. Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice. Nat Med. 2002;8:1089–1097
  14. Koren M, Kimmel G, Ben-Asher E, et al. ATM haplotypes and breast cancer risk in Jewish high-risk women. Br J Cancer. 2006;94:1537–1543
  15. Menheniott TR, Woodfine K, Schulz R, et al. Genomic imprinting of Dopa decarboxylase in heart and reciprocal allelic expression with neighboring Grb10. Mol Cell Biol. 2008;28:386–396
  16. Larkin MA, Blackshields G, Brown NP, et al. Clustal W and Clustal X version 2.0. Bioinformatics. 2007;23:2947–2948
  17. Gross SS, Do CB, Sirota M, et al. CONTRAST: a discriminative, phylogeny-free approach to multiple informant de novo gene prediction. Genome Biol. 2007;8:R269
  18. Bendtsen JD, Nielsen H, von Heijne G, et al. Improved prediction of signal peptides: SignalP 3.0. J Mol Biol. 2004;340:783–795
  19. Sambrook JF, Maniatis T. Molecular cloning: a laboratory manual. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press; 1989;
  20. Shen CN, Slack JM, Tosh D. Molecular basis of transdifferentiation of pancreas to liver. Nat Cell Biol. 2000;2:879–887
  21. Freshney R. Culture of animal cells: a manual of basic technique. New York, NY: Alan R. Liss, Inc; 1987;
  22. Kozak M. Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes. Cell. 1986;44:283–292
  23. Zavros Y, Eaton KA, Kang W, et al. Chronic gastritis in the hypochlorhydric gastrin-deficient mouse progresses to adenocarcinoma. Oncogene. 2005;24:2354–2366
  24. May FE, Griffin SM, Westley BR. The trefoil factor interacting protein TFIZ1 binds the trefoil protein TFF1 preferentially in normal gastric mucosal cells but the co-expression of these proteins is deregulated in gastric cancer. Int J Biochem Cell Biol. 2009;41:632–640
  25. Chang YF, Imam JS, Wilkinson MF. The nonsense-mediated decay RNA surveillance pathway. Annu Rev Biochem. 2007;76:51–74
  26. Saleh M, Mathison JC, Wolinski MK, et al. Enhanced bacterial clearance and sepsis resistance in caspase-12-deficient mice. Nature. 2006;440:1064–1068
  27. MacArthur DG, Seto JT, Raftery JM, et al. Loss of ACTN3 gene function alters mouse muscle metabolism and shows evidence of positive selection in humans. Nat Genet. 2007;39:1261–1265
  28. Scarff KL, Judd LM, Toh BH, et al. Gastric H(+),K(+)-adenosine triphosphatase beta subunit is required for normal function, development, and membrane structure of mouse parietal cells. Gastroenterology. 1999;117:605–618
  29. Judd LM, Alderman BM, Howlett M, et al. Gastric cancer development in mice lacking the SHP2 binding site on the IL-6 family co-receptor gp130. Gastroenterology. 2004;126:196–207
  30. Ramsey VG, Doherty JM, Chen CC, et al. The maturation of mucus-secreting gastric epithelial progenitors into digestive-enzyme secreting zymogenic cells requires Mist1. Development. 2007;134:211–222
  31. Ribieras S, Lefebvre O, Tomasetto C, et al. Mouse Trefoil factor genes: genomic organization, sequences and methylation analyses. Gene. 2001;266:67–75
  32. Nomura S, Baxter T, Yamaguchi H, et al. Spasmolytic polypeptide expressing metaplasia to preneoplasia in H. felis-infected mice. Gastroenterology. 2004;127:582–594
  33. Saleh M, Vaillancourt JP, Graham RK, et al. Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms. Nature. 2004;429:75–79
  34. Resnick MB, Sabo E, Meitner PA, et al. Global analysis of the human gastric epithelial transcriptome altered by Helicobacter pylori eradication in vivo. Gut. 2006;55:1717–1724

 Conflicts of interest The authors disclose no conflicts.

 Funding This work was supported by the National Health and Medical Research Council of Australia.

PII: S0016-5085(10)00159-9

doi: 10.1053/j.gastro.2010.01.050

Gastroenterology
Volume 138, Issue 5 , Pages 1823-1835 , May 2010

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