Gastroenterology
Volume 138, Issue 5 , Pages 1966-1975.e1 , May 2010

Glucose-Dependent Insulinotropic Polypeptide Is Expressed in Pancreatic Islet α-Cells and Promotes Insulin Secretion

  • Yukihiro Fujita

      Affiliations

    • Laboratory of Molecular and Cellular Medicine, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada
    • Department of Cellular & Physiological Sciences, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada
    • ,
  • Rhonda D. Wideman

      Affiliations

    • Laboratory of Molecular and Cellular Medicine, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada
    • Department of Cellular & Physiological Sciences, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada
    • ,
  • Ali Asadi

      Affiliations

    • Laboratory of Molecular and Cellular Medicine, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada
    • Department of Cellular & Physiological Sciences, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada
    • ,
  • Gary K. Yang

      Affiliations

    • Laboratory of Molecular and Cellular Medicine, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada
    • Department of Cellular & Physiological Sciences, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada
    • ,
  • Robert Baker

      Affiliations

    • Laboratory of Molecular and Cellular Medicine, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada
    • Department of Cellular & Physiological Sciences, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada
    • ,
  • Travis Webber

      Affiliations

    • Laboratory of Molecular and Cellular Medicine, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada
    • Department of Cellular & Physiological Sciences, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada
    • ,
  • Tianjiao Zhang

      Affiliations

    • Laboratory of Molecular and Cellular Medicine, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada
    • Department of Cellular & Physiological Sciences, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada
    • ,
  • Rennian Wang

      Affiliations

    • Department of Physiology and Pharmacology, Children's Health Research Institute, University of Western Ontario, London, Ontario, Canada
    • ,
  • Ziliang Ao

      Affiliations

    • Department of Surgery, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada
    • ,
  • Garth L. Warnock

      Affiliations

    • Department of Surgery, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada
    • ,
  • Yin Nam Kwok

      Affiliations

    • Department of Cellular & Physiological Sciences, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada
    • ,
  • Timothy J. Kieffer

      Affiliations

    • Laboratory of Molecular and Cellular Medicine, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada
    • Department of Cellular & Physiological Sciences, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada
    • Department of Surgery, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada
    • Corresponding Author InformationReprint requests Address requests for reprints to: Timothy J. Kieffer, PhD, 2350 Health Sciences Mall, Vancouver, British Columbia, V6T 1Z3 Canada. fax: (604) 822-2316

Received 4 December 2008 ,Accepted 27 January 2010.

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 Conflicts of interest The authors disclose no conflicts.

 Funding Timothy Kieffer is a Michael Smith Foundation for Health Research senior scholar and received grant funding from the Juvenile Diabetes Research Foundation and the Michael Smith Foundation for Health Research through the Centre for Human Islet Transplant and Beta-Cell Regeneration; Yukihiro Fujita received scholarship support from the Canadian Diabetes Association and the Stem Cell Network; Rhonda Wideman received scholarship support from the Michael Smith Foundation for Health Research and the Natural Sciences and Engineering Research Council; and Gary Yang received scholarship support from Natural Sciences and Engineering Research Council.

PII: S0016-5085(10)00158-7

doi: 10.1053/j.gastro.2010.01.049

Gastroenterology
Volume 138, Issue 5 , Pages 1966-1975.e1 , May 2010

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