Gastroenterology
Volume 138, Issue 5 , Pages 1810-1822.e2 , May 2010

Aberrant Epithelial–Mesenchymal Hedgehog Signaling Characterizes Barrett's Metaplasia

  • David H. Wang

      Affiliations

    • Graduate Training Program in Cellular and Molecular Medicine, Johns Hopkins University, Baltimore, Maryland
    • Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland
    • Department of Oncology, Johns Hopkins University, Baltimore, Maryland
    • Corresponding Author InformationReprint requests Address requests for reprints to: David H. Wang, MD, PhD, VANTHCS/UT Southwestern Medical Center, Research Service (151), 4500 S. Lancaster Road, Dallas, Texas 75216. fax: (214) 462-4953
    • ,
  • Nicholas J. Clemons

      Affiliations

    • Surgical Oncology Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
    • ,
  • Tomoharu Miyashita

      Affiliations

    • Department of Surgery, Johns Hopkins University, Baltimore, Maryland
    • ,
  • Adam J. Dupuy

      Affiliations

    • Department of Anatomy and Cell Biology, University of Iowa, Iowa City, Iowa
    • ,
  • Wei Zhang

      Affiliations

    • Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland
    • Department of Oncology, Johns Hopkins University, Baltimore, Maryland
    • ,
  • Anette Szczepny

      Affiliations

    • Centre for Cancer Research, Monash Institute of Medical Research, Clayton, Victoria, Australia
    • ,
  • Ian M. Corcoran–Schwartz

      Affiliations

    • Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland
    • Department of Oncology, Johns Hopkins University, Baltimore, Maryland
    • ,
  • Daniel L. Wilburn

      Affiliations

    • Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland
    • Department of Oncology, Johns Hopkins University, Baltimore, Maryland
    • ,
  • Elizabeth A. Montgomery

      Affiliations

    • Department of Pathology, Johns Hopkins University, Baltimore, Maryland
    • ,
  • Jean S. Wang

      Affiliations

    • Department of Medicine, Johns Hopkins University, Baltimore, Maryland
    • ,
  • Nancy A. Jenkins

      Affiliations

    • Institute of Molecular and Cell Biology, Singapore
    • ,
  • Neal A. Copeland

      Affiliations

    • Institute of Molecular and Cell Biology, Singapore
    • ,
  • John W. Harmon

      Affiliations

    • Department of Surgery, Johns Hopkins University, Baltimore, Maryland
    • ,
  • Wayne A. Phillips

      Affiliations

    • Surgical Oncology Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
    • ,
  • D. Neil Watkins

      Affiliations

    • Graduate Training Program in Cellular and Molecular Medicine, Johns Hopkins University, Baltimore, Maryland
    • Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland
    • Department of Oncology, Johns Hopkins University, Baltimore, Maryland
    • Centre for Cancer Research, Monash Institute of Medical Research, Clayton, Victoria, Australia
    • Corresponding Author InformationD. Neil Watkins, MMBS, PhD, FRACP, Monash Institute of Medical Research, 27-31 Wright Street, Clayton VIC 3168, Australia. fax: +61 3 9594-7252

Received 19 March 2008 ,Accepted 27 January 2010.

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 Conflicts of interest The authors disclose no conflicts.

 Funding This work was supported by an American Society of Clinical Oncology (ASCO) Young Investigator Award (D.H.W.), Ruth L. Kirschstein NRSA F32CA-123945 (D.H.W.), a Victorian Cancer Agency Early Career Seed Grant (N.J.C.), Australian Research Council Discovery Project Grant DP0878303 (N.J.C.), National Institutes of Health grant 1K23DK068149 (J.S.W.), the Sidney Kimmel Cancer Research Foundation (D.N.W.), and the National Health and Medical Research Council (NHMRC) Australia, Fellowship 546107/Project Grant 546098 (D.N.W.). The Jerry D'Amato Charity Foundation and the Roy L. Jeannotte Foundation supported construction of the esophageal tissue microarrays.

PII: S0016-5085(10)00157-5

doi: 10.1053/j.gastro.2010.01.048

Gastroenterology
Volume 138, Issue 5 , Pages 1810-1822.e2 , May 2010

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