Gastroenterology
Volume 138, Issue 5 , Pages 1954-1965.e8 , May 2010

α Cell–Specific Men1 Ablation Triggers the Transdifferentiation of Glucagon-Expressing Cells and Insulinoma Development

  • Jieli Lu

      Affiliations

    • Laboratoire Génétique Moléculaire, Signalisation et Cancer, Centre National de la Recherche Scientifique, UMR5201, Université Claude Bernard Lyon1, Centre LEON-BERARD, Lyon, France
    • ,
  • Pedro L. Herrera

      Affiliations

    • Department of Genetic Medicine and Development, Faculty of Medicine, University of Geneva, Geneva, Switzerland
    • ,
  • Christine Carreira

      Affiliations

    • Laboratoire Génétique Moléculaire, Signalisation et Cancer, Centre National de la Recherche Scientifique, UMR5201, Université Claude Bernard Lyon1, Centre LEON-BERARD, Lyon, France
    • ,
  • Rémy Bonnavion

      Affiliations

    • Laboratoire Génétique Moléculaire, Signalisation et Cancer, Centre National de la Recherche Scientifique, UMR5201, Université Claude Bernard Lyon1, Centre LEON-BERARD, Lyon, France
    • ,
  • Christelle Seigne

      Affiliations

    • Laboratoire Génétique Moléculaire, Signalisation et Cancer, Centre National de la Recherche Scientifique, UMR5201, Université Claude Bernard Lyon1, Centre LEON-BERARD, Lyon, France
    • ,
  • Alain Calender

      Affiliations

    • Laboratoire Génétique Moléculaire, Signalisation et Cancer, Centre National de la Recherche Scientifique, UMR5201, Université Claude Bernard Lyon1, Centre LEON-BERARD, Lyon, France
    • ,
  • Philippe Bertolino

      Affiliations

    • Laboratoire Génétique Moléculaire, Signalisation et Cancer, Centre National de la Recherche Scientifique, UMR5201, Université Claude Bernard Lyon1, Centre LEON-BERARD, Lyon, France
    • ,
  • Chang Xian Zhang

      Affiliations

    • Laboratoire Génétique Moléculaire, Signalisation et Cancer, Centre National de la Recherche Scientifique, UMR5201, Université Claude Bernard Lyon1, Centre LEON-BERARD, Lyon, France
    • Corresponding Author InformationReprint requests Address requests for reprints to: Chang Xian Zhang, Laboratoire Génétique Moléculaire, Signalisation et Cancer, CNRS UMR5201, Université Claude Bernard Lyon1, Centre LEON-BERARD, 28 Rue Laennec 69008, Lyon, France. fax: (33) 469 16 66 60

Received 20 August 2009 ,Accepted 25 January 2010.

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 Conflicts of interest The authors disclose no conflicts.

 Funding This study was supported by the Association pour la Recherche contre le Cancer (grants CZ4054 and 1146) and Ligue contre le Cancer de la Loire and du Rhône (to C.X.Z.); J.L. and P.B. were the recipients of fellowships from the Association pour la Recherche contre le Cancer.

PII: S0016-5085(10)00155-1

doi: 10.1053/j.gastro.2010.01.046

Gastroenterology
Volume 138, Issue 5 , Pages 1954-1965.e8 , May 2010

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