Gastroenterology
Volume 138, Issue 4 , Pages 1266-1275, April 2010

Epithelial Uptake of [18F]1-(2′-Deoxy-2′-Arabinofuranosyl) Cytosine Indicates Intestinal Inflammation in Mice

  • Sarah Brewer

      Affiliations

    • Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California
    • ,
  • Evan Nair–Gill

      Affiliations

    • Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California
    • ,
  • Bo Wei

      Affiliations

    • Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California
    • ,
  • Ling Chen

      Affiliations

    • Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California
    • ,
  • Xiaoxiao Li

      Affiliations

    • Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California
    • ,
  • Mireille Riedinger

      Affiliations

    • Department of Microbiology, Immunology and Molecular Genetics, and Howard Hughes Medical Institute, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California
    • ,
  • Dean O. Campbell

      Affiliations

    • Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California
    • ,
  • Stephanie Wiltzius

      Affiliations

    • Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California
    • ,
  • Nagichettiar Satyamurthy

      Affiliations

    • Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California
    • ,
  • Michael E. Phelps

      Affiliations

    • Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California
    • ,
  • Caius Radu

      Affiliations

    • Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California
    • ,
  • Owen N. Witte

      Affiliations

    • Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California
    • Department of Microbiology, Immunology and Molecular Genetics, and Howard Hughes Medical Institute, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California
    • ,
  • Jonathan Braun

      Affiliations

    • Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California
    • Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California
    • Corresponding Author InformationReprint requests Address requests for reprints to: Jonathan Braun, Department of Pathology and Laboratory Medicine, University of California Los Angeles, Los Angeles, California 90095-1732. fax: (310) 825-5674

Received 31 May 2009; accepted 7 January 2010. published online 18 January 2010.

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 Conflicts of interest These authors disclose the following: Owen Witte, Caius Radu, and Evan Nair-Gill are co-inventors on patent filings for novel positron emission tomography probes for immunity and cancer; Owen Witte, Caius Radu, and Michael Phelps are founders and stockholders in Sofie Biosciences, which is licensing this probe technology. The remaining authors disclose no conflicts.

 Funding Supported by National Institutes of Health grants CA86306 (J.B., D.O.C.), AI52031 (S.B.), A1065067 (E.N.G.), and GM08042 (E.N.G.); Howard Hughes Medical Institute (O.N.W.); and the Charles A. Dana Foundation (C.R.).

PII: S0016-5085(10)00019-3

doi:10.1053/j.gastro.2010.01.003

Gastroenterology
Volume 138, Issue 4 , Pages 1266-1275, April 2010

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