Gastroenterology
Volume 138, Issue 4 , Pages 1346-1356.e3 , April 2010

Trunk Fat Is Associated With Increased Serum Levels of Alanine Aminotransferase in the United States

  • Constance E. Ruhl

      Affiliations

    • Social & Scientific Systems, Inc., Silver Spring, Maryland
    • Corresponding Author InformationReprint requests Address requests for reprints to: Constance E. Ruhl, MD, PhD, Social & Scientific Systems, Inc., 8757 Georgia Avenue, 12th Floor, Silver Spring, MD 20910. fax: 301-628-3201
    • ,
  • James E. Everhart

      Affiliations

    • National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland

Received 10 November 2009 ,Accepted 30 December 2009.

  • Image Result

    (A) Multivariate-adjusted odds ratio (OR) for elevated alanine aminotransferase (ALT) comparing upper relative to lowest body composition index quintile and adjusting for all 3 other measures among me

    (A) Multivariate-adjusted odds ratio (OR) for elevated alanine aminotransferase (ALT) comparing upper relative to lowest body composition index quintile and adjusting for all 3 other measures among men. (B) Multivariate-adjusted OR for elevated ALT comparing upper relative to lowest body composition index quintile and adjusting for all 3 other measures among women. (C) Multivariate-adjusted OR for elevated ALT comparing upper relative to lowest quintile of trunk fat, body mass index (BMI), and waist circumference and adjusting for the other 2 measures among men. (D) Multivariate-adjusted OR for elevated ALT comparing upper relative to lowest quintile of trunk fat, BMI, and waist circumference and adjusting for the other 2 measures among women.

  • Image Result
    Prevalence of elevated alanine aminotransferase (ALT) by trunk fat and extremity fat tertiles among women.

    Prevalence of elevated alanine aminotransferase (ALT) by trunk fat and extremity fat tertiles among women.

 This article has an accompanying continuing medical education activity on page e12. Learning Objective: Upon completion of reading this article, successful learners will be able to explain the relationships of body composition measures with elevated ALT activity in the US population.

 Conflicts of interest The authors disclose no conflicts.

 Funding This work was supported by a contract from the National Institute of Diabetes and Digestive and Kidney Diseases (HHSN267200700001G).

PII: S0016-5085(10)00005-3

doi: 10.1053/j.gastro.2009.12.053

Gastroenterology
Volume 138, Issue 4 , Pages 1346-1356.e3 , April 2010

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