This Month in Gastroenterology

Kaplan–Meier estimate of the time course to remission in tissue samples in the 2 groups of the randomized, controlled trial.

Cumulative incidence of gastric cancer in male and female Lynch syndrome carriers.

T-cell secretion of TNF-α, IFN-γ, and IL-2 is inhibited by MK001 (silymarin). Peripheral blood mononuclear cells from an HCV-infected subject were enriched for T cells and cultured with 0.5% DMSO or media (not shown), or plate-bound anti-CD3 (10 μg/ml) in the presence of MK001 (20 μg/mL) or vehicle (DMSO) for 24 hours. TNF-α, IFN-γ, and IL-2 levels in culture supernatants were evaluated using multiplex enzyme-linked immunosorbent assay. Detection limits were 2, 2, and 4 pg/mL, respectively.

Genetic deletion of Gpbar1 reduces the severity of TLCS-induced pancreatitis. Acute pancreatitis was induced in wild-type and Gpbar1^−/− mice by retrograde ductal infusion with 3 mM TLCS. Twenty-four hours after the start of pancreatitis induction, animals were humanely killed and pancreatitis severity was evaluated. Solid bars report results obtained using wild-type mice and open bars report results from Gpbar1^−/− animals. *Significant differences in bracketed groups in which results from wild-type and Gpbar1^−/− mice are compared. NS, not significant.