Gastroenterology
Volume 138, Issue 2 , Pages 426-429 , February 2010

Sonic Hedgehog: A Link Between Inflammation, Gastric Atrophy, and Acid Suppression?

  • Willemijn A. Van Dop

      Affiliations

    • Center for Experimental Molecular Medicine and Department of Gastroenterology & Hepatology, Academic Medical Center, Amsterdam, The Netherlands
    • ,
  • Gijs R. Van Den Brink

      Affiliations

    • Department of Gastroenterology & Hepatology, Leiden University Medical Center, Leiden, The Netherlands
    • Corresponding Author InformationReprint requests Address requests for reprints to: Gijs R. van den Brink, Department of Gastroenterology & Hepatology, Leiden University Medical Center, Leiden, The Netherlands

References 

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  2. Van Den Brink GR, Hardwick JC, Nielsen C, et al. Sonic hedgehog expression correlates with fundic gland differentiation in the adult gastrointestinal tract. Gut. 2002;51:628–633
  3. Takagi H, Jhappan C, Sharp R, et al. Hypertrophic gastropathy resembling Ménétrier's disease in transgenic mice overexpressing transforming growth factor alpha in the stomach. J Clin Invest. 1992;90:1161–1167
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  9. Shiotani A, Iishi H, Uedo N, et al. Evidence that loss of sonic hedgehog is an indicator of Helicobacter pylori-induced atrophic gastritis progressing to gastric cancer. Am J Gastroenterol. 2005;100:581–587
  10. Suzuki H, Minegishi Y, Nomoto Y, et al. Down-regulation of a morphogen (sonic hedgehog) gradient in the gastric epithelium of Helicobacter pylori-infected Mongolian gerbils. J Pathol. 2005;206:186–197
  11. Zavros Y, Waghray M, Tessier A, et al. Reduced pepsin a processing of sonic hedgehog in parietal cells precedes gastric atrophy and transformation. J Biol Chem. 2007;282:33265–33274
  12. Kolterud A, Grosse AS, Zacharias WJ, et al. Paracrine Hedgehog signaling in stomach and intestine: new roles for hedgehog in gastrointestinal patterning. Gastroenterology. 2009;137:618–628
  13. El-Omar EM, Carrington M, Chow WH, et al. Interleukin-1 polymorphisms associated with increased risk of gastric cancer. Nature. 2000;404:398–402
  14. Wallace JL, Cucala M, Mugridge K, et al. Secretagogue-specific effects of interleukin-1 on gastric acid secretion. Am J Physiol. 1991;261:G559–G564
  15. Beales IL, Calam J. Interleukin 1 beta and tumour necrosis factor alpha inhibit acid secretion in cultured rabbit parietal cells by multiple pathways. Gut. 1998;42:227–234
  16. Waghray M, Zavros Y, Saqui-Salces M, et al. Interleukin-1β promotes gastric atrophy through suppression of sonic Hedgehog. Gastroenterology. 2010;38:562–572
  17. Xiao C, Ogle SA, Schumacher MA, et al. Loss of parietal cell expression on sonic Hedgehog induces hypergastrinemia and hyperproliferation of surface mucous cells. Gastroenterology. 2010;38:550–561
  18. Van dop WA, Uhmann A, Wijgerde M, et al. Depletion of the colonic epithelial precursor cell compartment upon conditional activation of the hedgehog pathway. Gastroenterology. 2009;136:2195–2203
  19. Stepan V, Ramamoorthy S, Nitsche H, et al. Regulation and function of the sonic hedgehog signal transduction pathway in isolated gastric parietal cells. J Biol Chem. 2005;280:15700–15708

 Conflicts of interest The authors disclose no conflicts.

PII: S0016-5085(09)02155-6

doi: 10.1053/j.gastro.2009.12.013

Gastroenterology
Volume 138, Issue 2 , Pages 426-429 , February 2010

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