Gastroenterology
Volume 138, Issue 2 , Pages 422-426 , February 2010

IV or Not IV? Just One of the Antibiotic Questions in Whipple's Disease

  • Cynthia L. Sears

      Affiliations

    • Divisions of Infectious Diseases and Gastroenterology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland
    • Corresponding Author InformationReprint requests Address requests for reprints to: Cynthia L. Sears, MD, The Johns Hopkins University School of Medicine, 1550 Orleans Street, CRB2 Building, Suite 1M.05, Baltimore, Maryland 21231. fax: 410-614-8173
    • ,
  • Sara E. Cosgrove

      Affiliations

    • Division of Infectious Diseases, Department of Medicine, The Johns Hopkins University, School of Medicine, Baltimore, Maryland

References 

  1. Whipple GH. A hitherto undescribed disease characterized anatomically by deposits of fat and fatty acids in the intestinal and mesenteric lymphatic tissues. Johns Hopkins Medical Bulletin. 1907;198:382–391
  2. Relman DA, Schmidt TM, MacDermott RP, et al. Identification of the uncultured bacillus of Whipple's disease. N Engl J Med. 1992;327:293–301
  3. Feurle GE, Junga NS, Marth T. Efficacy of ceftriaxone or meropenem as initial therapies in Whipple's disease. Gastroenterology. 2010;138:478–486
  4. In:  Kucers A,  Crowe SM,  Grayson ML, et al. editor. The use of antibiotics: A clinical review of antibacterial, antifungal and antiviral drugs. 5th ed.. Woburn, MA: Butterworth–Heinemann; 1997;
  5. Boulos A, Rolain JM, Raoult D. Antibiotic susceptibility of Tropherma whipplei in MRC5 cells. Antimicrob Agents Chemother. 2004;48:747–752
  6. Boulos A, Rolain JM, Mallet MN Butterworth Heinemann. Molecular evaluation of antibiotic susceptibility of Tropheryma whipplei in axenic medium. J Antimicrob Chemother. 2005;55:178–181

 Conflicts of interest The authors disclose the following: Dr Sara E. Cosgrove serves on the advisory board of Forest Laboratories, as a consultant to Merck, and receives grant support from Cubist and Astellas. Dr Cynthia L. Sears discloses no conflicts.

PII: S0016-5085(09)02153-2

doi: 10.1053/j.gastro.2009.12.011

Gastroenterology
Volume 138, Issue 2 , Pages 422-426 , February 2010

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