Gastroenterology
Volume 138, Issue 4 , Pages 1330-1337 , April 2010

Hip Fracture Risk in Patients With a Diagnosis of Pernicious Anemia

  • Nathan A. Merriman

      Affiliations

    • Division of Gastroenterology, Center for Clinical Epidemiology and Biostatistics, Philadelphia, Pennsylvania
    • Department of Biostatistics and Epidemiology, Philadelphia, Pennsylvania
    • ,
  • Mary E. Putt

      Affiliations

    • Department of Biostatistics and Epidemiology, Philadelphia, Pennsylvania
    • University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
    • ,
  • David C. Metz

      Affiliations

    • Division of Gastroenterology, Center for Clinical Epidemiology and Biostatistics, Philadelphia, Pennsylvania
    • ,
  • Yu–Xiao Yang

      Affiliations

    • Division of Gastroenterology, Center for Clinical Epidemiology and Biostatistics, Philadelphia, Pennsylvania
    • Department of Biostatistics and Epidemiology, Philadelphia, Pennsylvania
    • University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
    • Corresponding Author InformationReprint requests Address requests for reprints to: Yu-Xiao Yang, MD, MSCE, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, 722 Blockley Hall, 423 Guardian Drive, Philadelphia, Pennsylvania 19104-6021. fax: (215) 349-5915

Received 4 May 2009 ,Accepted 9 December 2009.

References 

  1. Kim GS, Kim CH, Park JY, et al. Effects of vitamin B12 on cell proliferation and cellular alkaline phosphatase activity in human bone marrow stromal osteoprogenitor cells and UMR106 osteoblastic cells. Metab Clin Exp. 1996;45:1443–1446
  2. Carmel R, Lau KH, Baylink DJ, et al. Cobalamin and osteoblast-specific proteins. N Engl J Med. 1988;319:70–75
  3. Tucker KL, Hannan MT, Qiao N, et al. Low plasma vitamin B12 is associated with lower BMD: the Framingham Osteoporosis Study. J Bone Miner Res. 2005;20:152–158
  4. McLean RR, Jacques PF, Selhub J, et al. Plasma B vitamins, homocysteine and their relation with bone loss and hip fracture in elderly men and women. J Clin Endocrin Metab. 2008;93:2206–2212
  5. Sato Y, Honda Y, Iwamoto J, et al. Effect of folate and mecobalamin on hip fractures in patients with stroke: a randomized controlled trial. [see comment][erratum appears in JAMA. 2006 Jul 26;296(4):396; PMID: 16868295] JAMA. 2005;293:1082–1088
  6. Gagnemo-Persson R, Hakanson R, Sundler F, et al. Growth of the parathyroid glands in omeprazole-treated chickens. Scand J Gastroenterol. 1994;29:493–497
  7. Grimelius L, Johansson H, Lundqvist G, et al. The parathyroid glands in experimentally induced hypergastrinemia in the rat. Scand J Gastroenterol. 1977;12:739–744
  8. Mizunashi K, Furukawa Y, Katano K, et al. Effect of omeprazole, an inhibitor of H+,K(+)-ATPase, on bone resorption in humans. Calcif Tissue Int. 1993;53:21–25
  9. Chonan O, Takahashi R, Yasui H, et al. Effect of L-lactic acid on the absorption of calcium in gastrectomized rats. J Nutr Sci Vitaminol. 1998;44:869–875
  10. Chonan O, Takahashi R, Yasui H, et al. Effect of L-lactic acid on calcium absorption in rats fed omeprazole. J Nutr Sci Vitaminol. 1998;44:473–481
  11. Recker RR. Calcium absorption and achlorhydria. N Engl J Med. 1985;313:70–73
  12. Eastell R, Vieira NE, Yergey AL, et al. Pernicious anaemia as a risk factor for osteoporosis. Clin Sci (Lond). 1992;82:681–685
  13. Graziani G, Como G, Badalamenti S, et al. Effect of gastric acid secretion on intestinal phosphate and calcium absorption in normal subjects. Nephrol Dial Transplant. 1995;10:1376–1380
  14. Marcuard SP, Albernaz L, Khazanie PG. Omeprazole therapy causes malabsorption of cyanocobalamin (vitamin B12). [see comment] Ann Intern Med. 1994;120:211–215
  15. Schenk BE, Festen HP, Kuipers EJ, et al. Effect of short- and long-term treatment with omeprazole on the absorption and serum levels of cobalamin. Aliment Pharmacol Ther. 1996;10:541–545
  16. Saltzman JR, Kemp JA, Golner BB, et al. Effect of hypochlorhydria due to omeprazole treatment or atrophic gastritis on protein-bound vitamin B12 absorption [see comment]. J Am Coll Nutr. 1994;13:584–591
  17. O'Connell MB, Madden DM, Murray AM, et al. Effects of proton pump inhibitors on calcium carbonate absorption in women: a randomized crossover trial. Am J Med. 2005;118:778–781
  18. Targownik LE, Lix LM, Metge CJ, et al. Use of proton pump inhibitors and risk of osteoporosis-related fractures [see comment]. CMAJ Can Med Assoc J. 2008;179:319–326
  19. Vestergaard P, Rejnmark L, Mosekilde L. Proton pump inhibitors, histamine H2 receptor antagonists, and other antacid medications and the risk of fracture. Calcif Tissue Int. 2006;79:76–83
  20. Yang Y-X, Lewis JD, Epstein S, et al. Long-term proton pump inhibitor therapy and risk of hip fracture. JAMA. 2006;296:2947–2953
  21. Kaye JA, Jick H. Proton pump inhibitor use and risk of hip fractures in patients without major risk factors. Pharmacotherapy. 2008;28:951–959
  22. Goerss JB, Kim CH, Atkinson EJ, et al. Risk of fractures in patients with pernicious anemia. J Bone Miner Res. 1992;7:573–579
  23. Hollowell J. The General Practice Research Database: quality of morbidity data. Popul Trends. 1997;36–40
  24. Garcia Rodriguez LA, Gutthann SP. Use of the UK General Practice Research Database for pharmacoepidemiology. Br J Clin Pharmacol. 1998;45:419–425
  25. Walley T, Mantgani A. The UK General Practice Research Database. Lancet. 1997;350:1097–1099
  26. Chisholm J. The Read clinical classification [see comment]. BMJ. 1990;300:1092
  27. Perry J. OXMIS Problem Codes for Primary Medical Care. Oxford, London: Oxford, England: Oxmis Publications; 1978;
  28. van Staa TP, Wegman S, de Vries F, et al. Use of statins and risk of fractures. JAMA. 2001;285:1850–1855
  29. Mickey RM, Greenland S. The impact of confounder selection criteria on effect estimation [erratum appears in Am J Epidemiol 1989 Nov;130(5):1066]. Am J Epidemiol. 1989;129:125–137
  30. Lewis JD, Bilker WB, Weinstein RB, et al. The relationship between time since registration and measured incidence rates in the General Practice Research Database. Pharmacoepidemiol Drug Saf. 2005;14:443–451
  31. Graziani G, Badalamenti S, Como G, et al. Calcium and phosphate plasma levels in dialysis patients after dietary Ca-P overload (Role of gastric acid secretion). Nephron. 2002;91:474–479
  32. Bo-Linn GW, Davis GR, Buddrus DJ, et al. An evaluation of the importance of gastric acid secretion in the absorption of dietary calcium. J Clin Invest. 1984;73:640–647
  33. Serfaty-Lacrosniere C, Wood RJ, Voytko D, et al. Hypochlorhydria from short-term omeprazole treatment does not inhibit intestinal absorption of calcium, phosphorus, magnesium or zinc from food in humans. J Am Coll Nutr. 1995;14:364–368
  34. De Geronimo S, Romagnoli E, Diacinti D, et al. The risk of fractures in postmenopausal women with primary hyperparathyroidism. Eur J Endocrinol. 2006;155:415–420
  35. Larsson K, Lindh E, Lind L, et al. Increased fracture risk in hypercalcemia (Bone mineral content measured in hyperparathyroidism). Acta Orthop Scand. 1989;60:268–270

 Conflicts of interest The authors disclose the following: Dr Metz reports serving as a consultant and receiving honoraria and/or grant support from AstraZeneca, TAP Pharmaceutical Products, Altana, Wyeth-Ayerst Laboratories, Santarus, and Eisai. Dr Yang reports having served as a consultant for AstraZeneca and received grant support from AstraZeneca and GlaxoSmithKline. The remaining auhors disclose no conflicts.

 Funding Dr Merriman was supported by a National Institutes of Health educational training grant during his gastroenterology and epidemiologic training at the University of Pennsylvania. Dr Yang was supported by a National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Diseases Mentored Career Development Award (K08 DK062978), which also funded the access to the data in the General Practice Research Database. This study was supported by an academic development fund from the University of Pennsylvania to Dr Yang. The funding sponsors played no role in the study design in the collection, analysis, and interpretation of data.

PII: S0016-5085(09)02145-3

doi: 10.1053/j.gastro.2009.12.007

Gastroenterology
Volume 138, Issue 4 , Pages 1330-1337 , April 2010

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