Gastroenterology
Volume 138, Issue 3 , Pages 1166-1177, March 2010

Pancreatic Duct Glands Are Distinct Ductal Compartments That React to Chronic Injury and Mediate Shh-Induced Metaplasia

  • Oliver Strobel

      Affiliations

    • Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts
    • Department of General Surgery, University of Heidelberg, Heidelberg, Germany
    • ,
  • David E. Rosow

      Affiliations

    • Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts
    • ,
  • Elena Y. Rakhlin

      Affiliations

    • Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts
    • ,
  • Gregory Y. Lauwers

      Affiliations

    • Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts
    • ,
  • Amanda G. Trainor

      Affiliations

    • Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts
    • ,
  • Janivette Alsina

      Affiliations

    • Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts
    • ,
  • Carlos Fernández–Del Castillo

      Affiliations

    • Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts
    • ,
  • Andrew L. Warshaw

      Affiliations

    • Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts
    • ,
  • Sarah P. Thayer

      Affiliations

    • Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts
    • Corresponding Author InformationReprint requests Address requests for reprints to: Sarah P. Thayer, MD, PhD, Department of Surgery, Massachusetts General Hospital, 15 Parkman Street, WACC 460, Boston, Massachusetts 02114. fax: (617) 726 0630

Received 5 February 2009; accepted 2 December 2009. published online 18 December 2009.

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 Conflicts of interest The authors disclose no conflicts.

 Funding This work was supported by grants from the German Research Foundation (STR 690/1-1) and the Surgery Foundation Heidelberg (Lautenschläger Scholarship) (O.S.), the Karin Grunebaum Cancer Research Foundation (D.E.R.), the Lustgarten Foundation for Pancreatic Cancer Research (RFP05-008), and the National Institutes of Health (K08DK71329, P50CA127003, and P01CA117969) (S.P.T.).

PII: S0016-5085(09)02119-2

doi:10.1053/j.gastro.2009.12.005

Refers to article:

  • Tracking Down the Hedgehog's Lair in the Pancreas , 25 January 2010

    Anirban Maitra
    Gastroenterology March 2010 (Vol. 138, Issue 3, Pages 823-825)

Gastroenterology
Volume 138, Issue 3 , Pages 1166-1177, March 2010

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