Gastroenterology
Volume 138, Issue 1 , Pages 36-39 , January 2010

A Unique Subset of Peyer's Patches Express Lysozyme

  • Regino Mercado–Lubo
    • ,
  • Beth A. McCormick

      Affiliations

    • Corresponding Author InformationReprint requests Address requests for reprints to: Beth A. McCormick, PhD, Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655

References 

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  3. Ouellette AJ. IV (Paneth cell antimicrobial peptides and the biology of the mucosal barrier). Am J Physiol. 1999;277:G257–G2561
  4. Fahlgren A, Hammarstrom S, Danielsson A, et al. Increased expression of antimicrobial peptides and lysozyme in colonic epithelial cells of patients with ulcerative colitis. Clin Exp Immunol. 2003;131:90–101
  5. Zasloff M. Antimicrobial peptides in health and disease. N Engl J Med. 2002;347:1199–1200
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  9. Masschalck B, Michiels CW. Antimicrobial properties of lysozyme in relation to foodborne vegetative bacteria. Crit Rev Microbiol. 2003;29:191–214
  10. Salzman NH, Chou MM, de Jong H, et al. Enteric salmonella infection inhibits Paneth cell antimicrobial peptide expression. Infect Immun. 2003;71:1109–1115
  11. Lelouard H, Henri S, de Bovis B, et al. Pathogenic bacteria and dead cells are internalized by a unique subset of Peyer's patch dendritic cells that express lysozyme. Gastroenterology. 2010;138:173–184
  12. Sato A, Iwasaki A. Peyer's patch dendritic cells as regulators of mucosal adaptive immunity. Cell Mol Life Sci. 2005;62:1333–1338
  13. Iwasaki A, Kelsall BL. Localization of distinct Peyer's patch dendritic cell subsets and their recruitment by chemokines macrophage inflammatory protein (MIP)-3alpha, MIP-3beta, and secondary lymphoid organ chemokine. J Exp Med. 2000;191:1381–1394
  14. Iwasaki A, Kelsall BL. Unique functions of CD11b+, CD8 alpha+, and double-negative Peyer's patch dendritic cells. J Immunol. 2001;166:4884–4890
  15. Salazar-Gonzalez RM, Niess JH, Zammit DJ, et al. CCR6-mediated dendritic cell activation of pathogen-specific T cells in Peyer's patches. Immunity. 2006;24:623–632

 Conflicts of interest The authors disclose no conflicts.

PII: S0016-5085(09)02050-2

doi: 10.1053/j.gastro.2009.11.033

Gastroenterology
Volume 138, Issue 1 , Pages 36-39 , January 2010

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