Gastroenterology
Volume 138, Issue 1 , Pages 36-39 , January 2010

A Unique Subset of Peyer's Patches Express Lysozyme

  • Regino Mercado–Lubo
  • ,
  • Beth A. McCormick

      Affiliations

    • Corresponding Author InformationReprint requests Address requests for reprints to: Beth A. McCormick, PhD, Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655

  • Image Result

    Distribution of lysozyme expressing cells in within Peyer's patches of the intestinal epithelium. Antigens within the intestinal mucosa are transferred to the Peyer's patches via M cells and are typic

    Distribution of lysozyme expressing cells in within Peyer's patches of the intestinal epithelium. Antigens within the intestinal mucosa are transferred to the Peyer's patches via M cells and are typically acquired by dendritic cells. Highlighted in this illustration are the roles played by LysoDCs in the subepithelial dome of the Peyer's patches and the tingible macrophage population located in the germinal center in their ability to secrete lysozyme. Release of lysozyme by these cells may afford a primary tier of protection within the Peyer's patches.

 Conflicts of interest The authors disclose no conflicts.

PII: S0016-5085(09)02050-2

doi: 10.1053/j.gastro.2009.11.033

Gastroenterology
Volume 138, Issue 1 , Pages 36-39 , January 2010