Gastroenterology
Volume 138, Issue 1 , Pages 13-18.e3 , January 2010

RhoA/Rho-Kinase: Pathophysiologic and Therapeutic Implications in Gastrointestinal Smooth Muscle Tone and Relaxation

  • Satish Rattan

      Affiliations

    • Department of Medicine, Division of Gastroenterology & Hepatology, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania
    • Corresponding Author InformationReprint requests Address requests for reprints to: Dr Satish Rattan, Jefferson Medical College, Thomas Jefferson University, 1025 Walnut Street, Room # 901 College; Philadelphia, PA 19107
    • ,
  • Benjamin R. Phillips

      Affiliations

    • Department of Surgery, Division of Colon and Rectal Surgery, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania
    • ,
  • Pinckney J. Maxwell IV

      Affiliations

    • Department of Surgery, Division of Colon and Rectal Surgery, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania

References 

  1. Murthy KS. Signaling for contraction and relaxation in smooth muscle of the gut. Annu Rev Physiol. 2006;68:345–374
  2. Somlyo AP, Somlyo AV. Signal transduction by G-proteins, Rho-kinase and protein phosphatase to smooth muscle and non-muscle myosin II. J Physiol (Lond). 2000;522:177–185
  3. Gerthoffer WT. Signal-transduction pathways that regulate visceral smooth muscle function III (Coupling of muscarinic receptors to signaling kinases and effector proteins in gastrointestinal smooth muscles). Am J Physiol Gastrointest Liver Physiol. 2005;288:G849–G853
  4. Shimokawa H, Rashid M. Development of Rho-kinase inhibitors for cardiovascular medicine. Trends Pharmacol Sci. 2007;28:296–302
  5. Jin L, Burnett AL. RhoA/Rho-kinase in erectile tissue: mechanisms of disease and therapeutic insights. Clin Sci. 2006;110:153–165

 Conflicts of interest The authors disclose no conflicts.

 Funding Supported by National Institutes of Diabetes and Digestive and Kidney Diseases Grant DK-35385 and an institutional grant from Thomas Jefferson University.

PII: S0016-5085(09)02033-2

doi: 10.1053/j.gastro.2009.11.016

Gastroenterology
Volume 138, Issue 1 , Pages 13-18.e3 , January 2010

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